Conserved Protein Domain Family
bHLHzip_MLXIPL
?
cd19689: bHLHzip_MLXIPL 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.
Links
?
Statistics
?
PSSM-Id: 381532
Aligned: 5 rows
Threshold Bit Score: 151.273
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens Max (1NLW)-Mad basic region binds the DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1             # ### ### ##   #                       ##                                
Q9NP71       646 KTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPs--lKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEI 721  human
OCT94129     601 KVESRRITHISAEQKRRCNIKIGFDTLHNLVTTLRGQHs--nKLSKATTLQKTAEYVYKLQQERAQLQEEAQHLRCQI 676  African clawed frog
ABV72703     664 KMESRRITHISAEQKRRFNIKLGFDTLHSLVSTLSAQPs--iKVSKATTLQKTAEYICKLQQERAALQDEAQRLREQI 739  chicken
XP_014343378 717 KTETRRITHISAEQKRRFNIKLGFDTLHSLVMSLSSQPctksQISKAATLQKTAEYISKLQQERVQMQEETQRLRSEI 794  coelacanth
NP_001315623 705 RTDTRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPs--iKISKATTLQKTAEYISKMQQERAQLHEEAQRLRDQI 780  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap