Conserved Protein Domain Family
UBR-box_UBR7
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cd19677: UBR-box_UBR7 
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR7 and similar proteins
UBR7 (EC 2.3.2.27; also called N-recognin-7) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR7 may play an important role in spermiogenesis and fertilization.
Links
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Statistics
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PSSM-Id: 439075
Aligned: 49 rows
Threshold Bit Score: 80.0448
Created: 24-Sep-2018
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Zn
Feature 1:putative Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens UBR6 binds several Zn2+ ions through its UBR-box.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #  #                #  #   ##  #            # #     
Q8N806     45 KCSYSQGsv------------kRQALYACSTCtpeg------eepAGICLACSYeCHGSHKLFELYtkRNFRCDCGNskf 106 human
Q09329     34 TCTYSMGy-------------lKQPLYACLTCqkas------gslNAVCYSCSIsCHADHDLVDLFnkRHFRCDCGTtrt 94  Schizosaccharomyce...
Q4WYR7     61 ACTQALGp-------------lRQTLFACLTCnppsdkpdaahtsAGVCYSCSIaCHGEHTLVELFskRNFVCDCGTtrv 127 Aspergillus fumigatus
Q753Z5     30 KCTYSMGp-------------lRQPIFACRTCg-----------dIGVCYSCSIqCHTECDLVELFekRQFSCDCGTerq 85  Eremothecium gossypii
OMJ93927   36 KCSYDKGy-------------iTQELYLCKTCnnn-------sqgSGICIGCYLaCHLDHEVLEIGikSNFRCDCGNsrl 95  Stentor coeruleus
RKP17519   22 KCSYSQGy-------------vLQRVYRCLTCnpaae----geipRVTCYACSIsCHAEHEIEELWlkRSIRCDCCTvdn 84  Rozella allomycis ...
RYG56788   31 ACTYSLStpdlpaslqaavhgiTQPVYSCLTCfqag------gtyVGLCEPCMLrCHVDHEVIELGlrRNFRCDCPTvas 104 archaeon
ETO18356   86 YCTYPKGy-------------iSQRVFVCQTCnamnn---ndtnyVGICYACKNsCHAGHKILDIWtkDHFRCDCGYrgn 149 Reticulomyxa filosa
CCM16942  133 RCSYPRGy-------------lRQTAYICRTCvdear----adpqHAVCLACAEfCHGNHEVEEWGvrYNMRCDCCTq-- 193 Leishmania guyanensis
RHW69419  167 RCSYGKGy-------------aRQTAFVCRTCvdsga----adpsHAICYACAEvCHTGHDVEEWGvrYFMRCDCCTp-- 227 Trypanosoma brucei...

Feature 1           #    
Q8N806    107 k--nleCKLLP 115 human
Q09329     95 h--sipCNLRK 103 Schizosaccharomyces pombe 972h-
Q4WYR7    128 s-sglpCTLRN 137 Aspergillus fumigatus
Q753Z5     86 ksaektCKLRE 96  Eremothecium gossypii
OMJ93927   96 ---knpCTFIQ 103 Stentor coeruleus
RKP17519   85 ---tsqCFLEN 92  Rozella allomycis CSF55
RYG56788  105 s--tpcCAQQA 113 archaeon
ETO18356  150 ---ltkCVWNA 157 Reticulomyxa filosa
CCM16942  194 -----kCWRVP 199 Leishmania guyanensis
RHW69419  228 -----vCWRDI 233 Trypanosoma brucei equiperdum

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