5VMD


Conserved Protein Domain Family
UBR-box_UBR6_FBXO11

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cd19676: UBR-box_UBR6_FBXO11 
Click on image for an interactive view with Cn3D
UBR-box found in F-box only protein 11 (FBXO11) and similar proteins
FBXO11 (also called UBR6, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)) is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. FBXO11 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. FBXO11 does not bind N-terminal signals.
Statistics
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PSSM-Id: 439074
Aligned: 21 rows
Threshold Bit Score: 113.756
Created: 25-Sep-2018
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitehomodimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:5VMD: Homo sapiens UBR6 binds several Zn2+ ions through its UBR-box.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #    #  #        #  #   ##  #      #    # #        #    
5VMD_A         8 CLYKISSYtsyPMHDFYRCHTCNTtDRNAICVNCIKkCHQGHDVEFIRHDRFFCDCGagtlsnpCTLAG 76   human
Q94251       845 CLFKVSSNnsfPMHNFYRCTTCNTtERNAICTNCIRtCHRGHSVELVRFDRFFCDCGagtlerhCHLQN 913  Caenorhabditis elegans
NP_001071900 786 CLYKISSYtsyPMHHFYRCYTCNTtDKNAICVNCVRkCHQGHVTEFTRHDRFFCDCGagtlsntCCLAG 854  vase tunicate
NP_001086604 751 CLYKISSYtsyPMHDFYRCHTCNTtDRNAICVNCIKkCHQGHDVEFIRHDRFFCDCGagtlsnpCTLAG 819  African clawed frog
XP_007895027 760 CLYKISSYtsyPMHDFYRCHTCNTtDRNAICVNCIKkCHQGHDVEFIRHDRFFCDCGagtlsnpCTLAG 828  elephant shark
PIK52113     699 CLYKISSYtsyPMHDFYRCKTCNTtDRNAICVNCIRrCHAGHVVEFVTHDRFFCDCGagtlshqCQLAG 767  Japanese sea cucumber
PFX23257     580 CLYQVSGNtcfPMHDFYRCTTCGTsDGYAICVSCVKgCHEGHDVKFVRRDRFFCDCGagssgvlCKLVS 648  Stylophora pistillata
XP_019856280 718 CLYSISGDnsfPMHDFYRCLTCSQnESGVICISCIKqCHKDHNVQFVRHDRFFCDCGagalkcdCNLTG 786  Amphimedon queenslandica
Q86XK2       835 CLYKISSYtsyPMHDFYRCHTCNTtDRNAICVNCIKkCHQGHDVEFIRHDRFFCDCGagtlsnpCTLAG 903  human
PWA25637     865 CLYKISSYtsyPMHDFYRCHTCNTtDRNAICVNCIKkCHQGHDVEFIRHDRFFCDCGagtlsnpCTLAG 933  western mosquitofish

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