6LHN


Conserved Protein Domain Family
UBR-box_UBR3
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cd19673: UBR-box_UBR3 
Click on image for an interactive view with Cn3D
UBR-box found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
UBR3 (EC 2.3.2.27), also called ubiquitin-protein ligase E3-alpha-III (E3alpha-III), or N-recognin-3, or zinc finger protein 650, is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. It negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. It acts as a positive regulator of Hedgehog (Hh) signaling in Drosophila and vertebrates. It also plays an important role for genome stability by controlling cellular levels of the essential DNA repair protein APE1.
Links
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Statistics
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PSSM-Id: 439071
Aligned: 93 rows
Threshold Bit Score: 87.2471
Created: 25-Sep-2018
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:6LHN: Homo sapiens E3 ubiquitin-protein ligase PRT6 binds three Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #               #        #  #     #                # #           #    
6LHN_A          6 GGVCGSVWGqNDIAYRCRTCENDPTCAICVPCFQnGDHNSHDYSIIYTg--GGCCDCGDETAWKpDGFCSNHK 76  
ETO15925      109 MGVCGKEIKgKEPVYKCNTCAADSTCIQCVECFEnSDHTGHDVKRMFAs--GGCCDCGDPESWApKGFCKFHQ 179  Reticulomyxa filosa
ETP35475      109 KRVCGAIFSaDEIAYSCRNCQLDTTCVMCKDCFThSDHAGHDVYFQRTt-aGSSCDCGDVHAWKqSGFCSRHK 180  Phytophthora parasit...
GAX20904      184 PRPCGYVFKrGDIAWNCRTCQTDATCVICDTCFRhSDHQGHEVYFHRTs-pGGCCDCGDAEAWKsEGCCDKHR 255  Fistulifera solaris
XP_004362991  380 ITTCGYVFKnGEWGFQCKQCQEDSTSVLCEKCFRdSNHEGHDYQMIRVg-qGGCCDCGDSDSWKeEGFCSKHK 451  Cavenderia fasciculata
XP_012750965  202 DSTCGYVFKdNDWAFQCKRCQKDETSILCSKCFDeGKHVGHEIKRIRVs-sNGCCDCGDEDSWAkDGFCDAHT 273  Acytostelium subglob...
KYR02155      183 VSTCGKVFKmNDWGYQCTTCCLDATSIYCQSCFKdSDHKGHEFKAVRTg-aGGCCDCGDKDSILeSGFCSKHR 254  Tieghemostelium lacteum
ETO36279       73 SGMCGKEVRqGEPIYTCLTCATAETSVQCVECFDhADHTGHEVTLHCAn--GGCCDCGDPEAWNpIGFCKFHQ 143  Reticulomyxa filosa
RYH21476      101 KSICGRVFKkGDLVWTCRQCSKDPTCVQCDPCFKkSNHAGHEVYFHRSggsGGCCDCGDSEAWAkHGNCTEHN 173  archaeon
CDW76233       80 KGMCAKPLFfGDIIWECFDCQIQPLCIQCEECFEkTDHTGHKVIMHKNl--NGSCDCGDANNWKpSGNCSDHQ 150  Stylonychia lemnae

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