5Y82,5Y83


Conserved Protein Domain Family
TmYidC_peri

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cd19668: TmYidC_peri 
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Thermotoga maritima and similar domains
This subfamily is composed of Thermotoga maritima YidC (TmYidC) and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. The periplasmic domain of TmYidC shows no amino acid sequence identity with that of the prototypical Escherichia coli YidC (EcYidC), yet they adopt a similar fold. However, the periplasmic domain of TmYidC displays shorter beta strands and some differences in connectivity, compared to EcYidC.
Statistics
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PSSM-Id: 410998
Aligned: 26 rows
Threshold Bit Score: 169.76
Created: 3-Oct-2018
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y82_D         1 IKVVRSeKEIVVLTRfEEYHFDLEkgILKDFYTMVd----gRKHVFTYg----nDGFDVLDe-gTPLTVIEEPIVTGVGk 71  Thermotoga mari...
KUK93157      25 IEVQEFdSVLTLKIRtLELVFDTQkgVITSIHTVVdr---qRIHIFEYa----dDGFDVLDa--DRNELLPMSYEYREDp 95  Thermotogales b...
PMP69822      25 VQVSLSaTTATVTTKlYKYSVDLKegVLQNEYSVFy----eNVHSWENt----gDGLVLYYe-gKPLMPSGWTISPTGSg 95  Mesoaciditoga sp.
WP_051962517  27 VNVTVNsSTVTVKTKiYTYVVNVKtgLLEKGYLAFk----rDQLFWVYg----gDGFDLYAs-nTKLIPTSWNVNGKENs 97  Mesoaciditoga l...
WP_014296306  24 YTITTKaTEISLQMRlYEVNFDLNg-HMKDFSILQnrsntiFLNIYKYy----nDSFDILDe--NGNEILPESYKITEGk 96  Marinitoga piez...
KUK68441      24 LLTQEGtSTLIVSSKtLKVTLDTVkgLILGVTSYAdn---kSVEFYVYnetlgkDGFNIFDaegNELLPTSFSYRKDVDg 100 Mesotoga infera
WP_012744767  24 MTTKEGtDTLTISSKtFTIVLNTRlgVLDDIRINVdr---kVVDIYTYype-dpDGYNVYGs-nGELIPISFSYEEDENg 98  Kosmotoga
PWJ95962      25 VTENATdNSLKIDMKlMNIELDKLg-HMKNVSVVEfki-kkFNTIYEYl----nDSFDIIDp-eTQEEILPDNYSYRIDa 97  Oceanotoga teri...
WP_091403606  23 VIISENaTTIDLQTRiFDLSMDKQg-HILEYSIVDfrt-keYKLIYSYg----kDSFNLLDt-eTEEEIIPTDYQISVSe 95  Geotoga petraea
KUK15985      26 VSESSLnQEISIEMKlYRLKLDQNg-HILNFELFDsrt-kkYNLVYEYt----gDSYDILDa-qTMTEILPSNYNIRLAe 98  Petrotoga mobilis
5Y82_D        72 vs-egfSDEVSMVYNYg--yVKKIFTIKNnENYTFFVDIESs--KPVDVTVPRVSvdtsTDRYME--NYFASFNPk---- 140 Thermotoga mari...
KUK93157      96 i---ndTIVITFRYES----GSKTFIVPGnPYYEFDVVIDFt--VPVIVNLPFISf---EDRTTRrdSFFVSYNKl---- 159 Thermotogales b...
PMP69822      96 tfhtksNVTLNFFYNVngsrIEKSVTFVNnPDYEVTVSVKApkdMTLSLTFPTLEs---NFNRASg-DIFGSYYSk---- 167 Mesoaciditoga sp.
WP_051962517  98 fe-tqsDVSVNFFYTYngqqIKKTITFVNgPNYEVKVSVNGpkgLKMRMNFPALMsd-fNKIRDNg-KLFATYSSgy--- 171 Mesoaciditoga l...
WP_014296306  97 d---keYVEITFLFKNg---GEKSYKFYNsPYYDFDVSFKN---INGKVIIPTISyp-nTVAVDN--ELLISYLAk---- 160 Marinitoga piez...
KUK68441     101 ------NVIVTFNYEQ----GNKSFIILNsPYYDFKVELDFs--QKIEVALPFISy--aNQTLGPnsSYYLTYDKf---- 162 Mesotoga infera
WP_012744767  99 ------NILVYFFYDS----GTKTFVVKNdPYYDFDIILSFs-eEITAVSVPYISe--iNQKVHP--NFFITYAKp---- 159 Kosmotoga
PWJ95962      98 d---ekFIEVSYFYGNt---GVKTYRFYNdPNFHFDLELNN---LEGYVKIPTISyq-pGIRIMD--SRMISYIEklpdt 165 Oceanotoga teri...
WP_091403606  96 n---eeYVDMFFFFEGn---GLKKYRFYNdPNFHFDVEFVN---VEGLVTLPTISyr-pGIRQMQ--STMVSFIEe---- 159 Geotoga petraea
KUK15985      99 d---qtHVEIIYFFPNg---GQKIYKFYNdPNYHFDVQFKN---LNGYVVLPSISfs-sGIRYTD--NVFVSYIDk---- 162 Petrotoga mobilis
5Y82_D       141 -tRTLVLLKHDEgll---------feGTLKVN-----------GQKRFIVFMGPNKRTLIKKAFpe-----dYDVLIKAL 194 Thermotoga mari...
KUK93157     160 -nRQKTVVAIASe------------nGTFQTYqrflpqvslpaGRNTLGVFVGPLKLVYLSEALpd-----qYAEIRQVL 221 Thermotogales b...
PMP69822     168 -kGIVTFSSLSNgtf--------sndGIATFS-----------GNLDAKIYMGPVKNTLIFSVFpq-----kYDVISNLI 222 Mesoaciditoga sp.
WP_051962517 172 knIIVAKVKNGKfe----------ndGSVEFT-----------STTEALAYLGPVKNTEIFTLFpk-----dVTVISEIL 225 Mesoaciditoga l...
WP_014296306 161 --PIKSIFIFDSkdip-------ienNSIMIS-----------GSKTFKAYMGPRKYVFIKQVFpe-----kYDRIKELS 215 Marinitoga piez...
KUK68441     163 -sGQKTLFAITSm------------qGTFKFQryq-----tesGKGLLESFAGPMRLIHVKQALpq-----qYDAIVKDL 219 Mesotoga infera
WP_012744767 160 -dKQKTVCISYSeeg---------rfDVKRFYpn--------sGRATISAFAGPVKLIHISEAFpe-----iYEEIKKDL 216 Kosmotoga
PWJ95962     166 gkKFKALFAIDApsk---------ieNNLSFYt---------qGKTNAKIYMGPFKRTFVKETFse----ntYNDIKTML 223 Oceanotoga teri...
WP_091403606 160 --IPNTGENLDAlvavea---asqidNQLRYKt---------eGRTLSQVYMGPLKRTFMGEVFse----etYDRVSALL 221 Geotoga petraea
KUK15985     163 --SVLTGENLDSalaiytpgeiessqNQYLFPln--------ySDQKVISYLGPTKKIFIKETFdgieegntYSTIIDLM 232 Petrotoga mobilis
5Y82_D       195 VNIPG 199 Thermotoga maritima MSB8
KUK93157     222 NDFGA 226 Thermotogales bacterium 46_20
PMP69822     223 GTYPG 227 Mesoaciditoga sp.
WP_051962517 226 KDYPG 230 Mesoaciditoga lauensis
WP_014296306 216 KQVGA 220 Marinitoga piezophila
KUK68441     220 QDFGG 224 Mesotoga infera
WP_012744767 217 EEFGA 221 Kosmotoga
PWJ95962     224 KEVGA 228 Oceanotoga teriensis
WP_091403606 222 DEMGA 226 Geotoga petraea
KUK15985     233 QDLGK 237 Petrotoga mobilis
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