5MRG,6B1G,2N4P,5X4F,5MDI


Conserved Protein Domain Family
NTD_TDP-43
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cd19609: NTD_TDP-43 
N-terminal domain of transactive response DNA-binding protein 43
Transactive response DNA-binding protein of 43 kDa (TDP-43) is a nuclear DNA/RNA-binding protein involved in gene transcription and mRNA processing, transport, and translational regulation. It is vital to pre-mRNA and microRNA processing and regulates stress granule activity through the differential regulation of G3BP and TIA-1. It also forms aggregates implicated in amyotrophic lateral sclerosis. The N-terminal domain of TDP-43 is required for its physiological functions and pathological aggregation.
Links
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Statistics
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PSSM-Id: 410991
Aligned: 106 rows
Threshold Bit Score: 64.859
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:TDP-43 has a multi-domain architecture consisting of a well-folded N-terminal domain (NTD) that mediates self-interaction which is important with regard to its cell function
  • Structure:6B1G; Human TDP-43 N-terminal domain homodimer; contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                ########                   # ##  ## ##                         
5MRG_A        16 YIRVTEDEn-------dEPIEIPSEd--------------DGTVLLSTVtAQFPGACGLRYRNPvs-------------- 60  human
6B1G_A         7 YIRVTEDEn-------dEPIEIPSEd--------------DGTVLLSTVtAQFPGACGLRYRNPve-------------- 51  human
KRX96692      45 FIQMETPTsenivqvstGVLECPLEk--------------DGTLSLATLrSLLPGARGLWYKPSefk------------p 98  Trichinella pse...
CRK89605       6 YILVGGKYg--------KPIGLPLEe--------------DGTLLLTTIqSIFPDAIGLIFNDPeg-------------- 49  Clunio marinus
KHJ40366      11 MDLPSEQVvlv----ssGILECPLEr--------------DGTLALSTLqSQLPCARGLWYNVDdge------------s 60  pig whipworm
OTF70242      14 RIAICECLg-------kLPVYVPLEs--------------DGTLLVSKLsSIFPGAVNVQYMIGm--------------- 57  Euroglyphus maynei
CRK89613       3 TIISSEDL---------ERIFVNNEkfadrfrsvafaleeDGTLLLSTIqSVFNKSESLNFRDPis-------------- 59  Clunio marinus
PDM84896       8 SVRTVRVFv--------EPIEVELDe--------------DGGLQWSSLaSAFPGCSNLYYKGDe--------------- 50  Pristionchus pa...
XP_024498943   5 IDKITRQVlqi----hvEPIEIELNd-------------vDEEVLLPTLrTAFPHCCGLYYYDFkt-------------- 53  Strongyloides r...
KRX96691      45 FIQMETPTsenivqvstGVLECPLEk--------------DGTLSLATLrSLLPGARGLWYKPSefkpiqlmenqrnlcp 110 Trichinella pse...

Feature 1                                        
5MRG_A        61 qCMRGVRLVEGILHAPd---aGWGNLVYVVNY 89  human
6B1G_A        52 qCMRGVRLVEGILHAPd---aGWGNLVYVVNY 80  human
KRX96692      99 iRAIRIDGKSAKLMPPs---qGWGDRIYHVSF 127 Trichinella pseudospiralis
CRK89605      50 rGVFASRFDGSRFHPG-----GWYNDVIYYCA 76  Clunio marinus
KHJ40366      61 rRAIRFNGTTATFSPPr---dGWKDKVHYVSF 89  pig whipworm
OTF70242      58 nGWRIPKIIDGRIQEPpfdlgGWKCCDYFYCI 89  Euroglyphus maynei
CRK89613      60 gKIFPCDFSESRFHPPe---nGWSSEVIYVSI 88  Clunio marinus
PDM84896      51 nLKTMVKFDGKKFVRSg---gCWNDNTYYVTL 79  Pristionchus pacificus
XP_024498943  54 nKKNIVKFDGKKFLPPk---gDWLTQKIYANL 82  Strongyloides ratti
KRX96691     111 rVKDGVIEYITSVFCPe---mHREFQRFMTTF 139 Trichinella pseudospiralis

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