Conserved Protein Domain Family
RecA-like_PEX1_r2
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cd19526: RecA-like_PEX1_r2 
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1)
PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Links
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Statistics
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PSSM-Id: 410934
Aligned: 7 rows
Threshold Bit Score: 301.27
Created: 28-Nov-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative ATP
Feature 1:putative ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ########                                      
O74941        614 AKEAVRDIIESPVKYSLIYKQCRLRlpTGILLFGYPGCGKTYLASAISstfpvQFISIKGPELLDKYIGKseqgVRDLFS 693  fission yeast
NP_001123103   10 QKKLLEQVIIWPRKYPQLFESVGVPvsKGILLHGPSGCGKTLLANATIsnsnfSVVNVKGPELLSKYIGAseenVRLVFE 89   Caenorhabditi...
NP_652016     728 VVGVLEEVLMWPSRYPTIFNASPLRnqAGVLLYGPPGTGKTYLVSQLAtswnlRIISVKGPELLAKYIGQseenVRNLFN 807  fruit fly
Q54GX5        874 VRAMLKETIEWPTKYPKLFQSSPLRlrSGILLYGPTGCGKTLLASAIAgecglNFISVKGPELLNKYIGSseqgVRDVFS 953  Dictyostelium...
P46463        807 AKSILLETLEWPTKYAPIFSSCPLRlrSGILLYGYPGCGKTLLASAVAaqcglNFISIKGPEILNKYIGPseqsVRELFE 886  Komagataella ...
NP_001331458  843 IKNAIKEMIELPSKFPKIFAKSPLRlrSNVLLYGPPGCGKTHIVGAAAaacslRFISVKGPELLNKYIGAseqaVRDIFS 922  thale cress
Q5BL07        849 VRQILMDTIQLPAKYPELFANLPIRqrTGILLYGPPGTGKTLLAGVVAresgmNFISIKGPELLSKYIGAseqaVRDVFI 928  house mouse

Feature 1                                                                  #                     
O74941        694 RAQMakpCVLFFDEFDSVAPRRGQdstGVTDRVVNQILTQMDGaesl-dgvYIVAATTRPDMIDPALLRPGRLDKLIFC 771  fission yeast
NP_001123103   90 KARScapCILFFDELDSLAPKRGHdstGVTDRVVNQLLTELDGaeggmkgvIILGCTSRIDLIDDALLRPGRFDHHVYC 168  Caenorhabditis...
NP_652016     808 RARSarpCVLFFDEFDSLAPKRGHdstGVTDRVVNQLLTELDGvegl-qgvTVIAATSRPELLDPALLRSGRIDRLVEC 885  fruit fly
Q54GX5        954 RASSakpCVLFFDEFDSIAPRRGHdnsGVTDRVVNQFLTQLDGvegl-tgvYVLAATSRPDLIDPALLRPGRLDKSLYC 1031 Dictyostelium ...
P46463        887 RAQAakpCILFFDEFDSIAPKRGHdstGVTDRVVNQMLTQMDGaegl-dgvYVLAATSRPDLIDSALLRPGRLDKSVIC 964  Komagataella p...
NP_001331458  923 KAAAaapCILFFDEFDSIAPKRGHdntGVTDRVVNQFLTELDGvevl-tgvFVFAATSRPDLLDPALLRPGRLDRLLLC 1000 thale cress
Q5BL07        929 RAQAakpCILFFDEFESIAPRRGHdntGVTDRVVNQLLTQLDGvegl-qgvYVLAATSRPDLIDPALLRPGRLDKCVYC 1006 house mouse

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