3D8B,4L15


Conserved Protein Domain Family
RecA-like_Figl-1

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cd19525: RecA-like_Figl-1 
ATPase domain of Fidgetin-Like 1 (FIGL-1)
FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
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PSSM-Id: 410933
Aligned: 3 rows
Threshold Bit Score: 345.435
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3D8B; Homo sapiens Fidgetin-like Protein 1 with bound ADP, contacts at 4A
    View structure with Cn3D
  • Comment:contains Walker A and Walker B motifs

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            ####                                    #######          
3D8B_A     63 EPKMIELIMNEimdhgppvnweDIAGVEFAKATIKEIVVWPMLRPDiftglrgppKGILLFGPPGTGKTLIGKCIAsqsg 142 human
4L15_A     35 DENIISLIESEimsvnneigwaDVAGLEGAKKALREIVVLPFKRPDvftgirappKGVLLFGPPGTGKTMIGRCVAsqck 114 Caenorhabditis ele...
Q6DDU8    361 EPKMIELIMSEimdhgpplnwdDIAGLEFAKTTIKEIVVWPMLRPDiftglrgppKGILLFGPPGTGKTLIGKCIAcqsg 440 African clawed frog
Feature 1                                                                                     
3D8B_A    143 aTFFSISASSLTSKWvgegEKMVRALFAVARCqqPAVIFIDEIDsllsqrgdgehessRRIKTEFLVQLdgattssedri 222 human
4L15_A    115 aTFFNISASSLTSKWvgegEKLVRALFSVARLklPSVIFIDEIDsllssrsesehessRRIKTEFLVQLdgvntapderl 194 Caenorhabditis ele...
Q6DDU8    441 aTFFSISASSLTSKWvgegEKMVRALFTVARChqPAVIFIDEIDsllsqrgegehessRRIKTEFLVQLdgattssedri 520 African clawed frog
Feature 1                               
3D8B_A    223 LVVGATNRPqeIDEAARRRLVKRLYI 248 human
4L15_A    195 LVLGATNRPqeLDEAARRRFQKRLYI 220 Caenorhabditis elegans
Q6DDU8    521 LVVGATNRPqeIDEAARRRLVKRLYI 546 African clawed frog

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