3B9P,3VFD


Conserved Protein Domain Family
RecA-like_spastin

?
cd19524: RecA-like_spastin 
ATPase domain of spastin
Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
?
PSSM-Id: 410932
Aligned: 8 rows
Threshold Bit Score: 292.524
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative ATP
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         ####                                    #######                                
3B9P_A        22 DIAGQDVAKQALQEMVILPSVRPElftglrapaKGLLLFGPPGNGKTLLARAVAtecsaTFLNISAASLTSKYvgdGEKL 101 fruit fly
B7PXE3       375 DIAGQEVAKQALSEMVILPTDRPElftglrappKGLLLFGPPGNGKTMLAKAVAhesnsTFLNISAASLTSKYvgeGEKL 454 black-legged tick
Q6AZT2       327 DIAGQDLAKQALQEIVILPSIRPElftglrapaRGLLLFGPPGNGKTMLAKAVAaesnaTFFNISAASLTSKYvgeGEKL 406 African clawed ...
3VFD_A       116 DIAGQDLAKQALQEIVILPSLRPElftglrapaRGLLLFGPPGNGKTMLAKAVAaesnaTFFNISAASLTSKYvgeGEKL 195 human
Q5ZK92       340 DIAGQELAKQALQEIVILPSLRPElftglrapaRGLLLFGPPGNGKTMLAKAVAaesnaTFFNISAASLTSKYvgeGEKL 419 chicken
Q6NW58       296 DIAGQDLAKQALQEIVILPALRPElftglrapaRGLLLFGPPGNGKTMLAKAVAmesnaTFFNISAATLTSKYvgeGEKL 375 zebrafish
Q54KQ7       385 DVVGLDKVKQSLMESVILPNLRPDvftglrappKGLLLFGPPGNGKTMIAKAVAyeskvTFFSISSSSLTSKYvgdGEKL 464 Dictyostelium d...
NP_001323446  84 DVAGLNGAKQALLEMVILPAKRRDlftglrrpaRGLLLFGPPGNGKTMLAKAVAsesqaTFFNVSASSLTSKWvgeAEKL 163 thale cress
Feature 1                                                                                        
3B9P_A       102 VRALFAVARHmqPSIIFIDEVDsllserssseheasRRLKTEFLVEFDGLpgnpdgdrIVVLAATNRPQELDEAALRRFT 181 fruit fly
B7PXE3       455 VRALFAVARElqPSIIFIDEVDsllserkdneheatRRLKTEFLVEFDGLhtgs-eerVLVMGATNRPQELDDAALRRFT 533 black-legged tick
Q6AZT2       407 VRALFSVARElqPSIIFIDEVDsllcerregehdasRRLKTEFLIEFDGVqsgg-ddrVLVMGATNRPQELDDAVLRRFT 485 African clawed ...
3VFD_A       196 VRALFAVARElqPSIIFIDQVDsllcerregehdasRRLKTEFLIEFDGVqsag-ddrVLVMGATNRPQELDEAVLRRFI 274 human
Q5ZK92       420 VRALFAVARElqPSIIFIDEVDsllcerregehdasRRLKTEFLIEFDGVqssg-edrILVMGATNRPQELDDAVLRRFT 498 chicken
Q6NW58       376 VRALFAVARElqPSIIFIDEIDsllcerregehdasRRLKTEFLIEFDGVqsgg-derVLVMGATNRPQELDEAVLRRFA 454 zebrafish
Q54KQ7       465 VRALFAVATHfqPSIIFIDEIDsllterssneseasRRLKTEILVQFDGArtng-derVLVMGATNRPEDLDDAALRRLV 543 Dictyostelium d...
NP_001323446 164 VKTLFQVAISrqPSVIFMDEIDsimstrstseneasRRLKSEFLIQFDGVtsnp-ddlVIIIGATNKPQELDDAVLRRLV 242 thale cress
Feature 1             
3B9P_A       182 KRVYV 186 fruit fly
B7PXE3       534 KRVYV 538 black-legged tick
Q6AZT2       486 KRVYV 490 African clawed frog
3VFD_A       275 KRVYV 279 human
Q5ZK92       499 KRVYV 503 chicken
Q6NW58       455 KRIYV 459 zebrafish
Q54KQ7       544 KRIYV 548 Dictyostelium discoideum AX4
NP_001323446 243 KRIYV 247 thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap