6B5C


Conserved Protein Domain Family
RecA-like_KTNA1

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cd19522: RecA-like_KTNA1 
Katanin p60 ATPase-containing subunit A1
Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
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PSSM-Id: 410930
Aligned: 8 rows
Threshold Bit Score: 356.602
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATP
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ####                                    #######                                
6B5C_A        26 DIADLEEAKKLLREAVVLPMWMPDFfkgirrpwKGVLMVGPPGTGKTMLAKAVAtecgtTFFNVSSSTLTSKYrgesekl 105 human
Q9PUL2       207 DIADLEEAKKLLKEAVVLPMWMPEFfkgirrpwKGVLMVGPPGTGKTLLAKAVAtecktTFFNISSSTLTSKYrgesekl 286 African clawed ...
Q5RII9       205 DIADLEEAKKLLKEAVVLPMWMPEFfkgirrpwKGVLMVGPPGTGKTLLAKAVAtecrtTFFNVSSSTLTSKYrgesekl 284 zebrafish
Q1HGK7       211 DIADLVEAKKLLKEAVVLPMWMPEFfkgirrpwKGVLMVGPPGTGKTLLAKAVAtecktTFFNVSSSTLTSKYrgesekl 290 chicken
Q9BW62       209 DIADLEEAKKLLREAVVLPMWMPDFfkgirrpwKGVLMVGPPGTGKTMLAKAVAtecgtTFFNVSSSTLTSKYrgesekl 288 human
NP_001262276 327 DIADLHDAKRLLEEAVVLPMLMPDYfkgirrpwKGVLMVGPPGTGKTMLAKAVAtecgtTFFNVSSATLTSKYrgesekm 406 fruit fly
NP_178151    240 DVAGLSEAKRLLEEAVVLPLWMPEYfqgirrpwKGVLMFGPPGTGKTLLAKAVAtecgtTFFNVSSATLASKWrgeserm 319 thale cress
O61577       235 DIAGLTEAKRLLEEAVVLPLWMPDYfkgirrpwKGVLMVGPPGTGKTMLAKAVAtecgtTFFNVSSASLTSKYhgesekl 314 purple sea urchin
Feature 1                                                                                        
6B5C_A       106 VRLLFEMARFyaPTTIFIDQIDsicsrrgtsdeHEASRRVKSELLIQMdgvggale-nddpskmvMVLAATNFPwdIDEA 184 human
Q9PUL2       287 VRLLFEMARFyaPTTIFIDEIDsicsrrgtseeHEASRRVKAELLVQMdgvggase-nedpskmvMVLAATNFPwdIDEA 365 African clawed ...
Q5RII9       285 VRLLFEMARFyaPTTIFIDEIDsicsrrgtseeHEASRRVKAELLVQMdgvggtse--ndpskmvMVLAATNFPwdIDEA 362 zebrafish
Q1HGK7       291 VRLLFEMARFyaPTTIFIDEIDsicsrrgtseeHEASRRVKAELLVQMdgvggate-nddpskmvMVLAATNFPwdIDEA 369 chicken
Q9BW62       289 VRLLFEMARFyaPTTIFIDEIDsicsrrgtsdeHEASRRVKSELLIQMdgvggale-nddpskmvMVLAATNFPwdIDEA 367 human
NP_001262276 407 VRLLFEMARFyaPSTIFIDEIDslcsrrgseseHEASRRVKSELLVQMdgvggge----eqakvvMVLAATNFPwdIDEA 482 fruit fly
NP_178151    320 VRCLFDLARAyaPSTIFIDEIDslcnsrggsgeHESSRRVKSELLVQVdgvsntatnedgsrkivMVLAATNFPwdIDEA 399 thale cress
O61577       315 VRLLFEMARFyaPSTIFIDEIDsicskrgtgseHEASRRVKSELLIQMdgvsgpsa-geesskmvMVLAATNFPwdIDEA 393 purple sea urchin
Feature 1                   
6B5C_A       185 LRRRLEKRIYI 195 human
Q9PUL2       366 LRRRLEKRIYI 376 African clawed frog
Q5RII9       363 LRRRLEKRIYI 373 zebrafish
Q1HGK7       370 LRRRLEKRIYI 380 chicken
Q9BW62       368 LRRRLEKRIYI 378 human
NP_001262276 483 LRRRLEKRIYI 493 fruit fly
NP_178151    400 LRRRLEKRIYI 410 thale cress
O61577       394 LRRRLEKRIYI 404 purple sea urchin

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