3JZM,1U9I,4O0M,1U9I


Conserved Protein Domain Family
KaiC_C
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cd19484: KaiC_C 
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C-terminal domain of Circadian Clock Protein KaiC
KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Links
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Statistics
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PSSM-Id: 410892
Aligned: 14 rows
Threshold Bit Score: 325.821
Created: 16-Jul-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindinghexamer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3JZM; Synechococcus elongatus KaiC with bound ATP, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #######                     #            #          
3JZM_A       263 VSSGVvRLDEMc-gGGFFKDSIILATGATGTGKTLLVSRFVENACanKERAILFAYEESrAQLLRNAYSWgmdfeemerq 341 Synechococcus e...
4O0M_A       263 VSSGVkTLDEMc-gGGFFKDSIILATGATGTGKTLLVSKFLETGCqqGERALLFAYEESrAQLSRNASSWgidfeelerr 341 Thermosynechoco...
YP_001636853 252 ITSGNaELDRMc-gGGFFRDSIVLVSGATGTGKTLMATTFMAAGVrqQERSLLFAFEESrDQLFRNAIGWgidfeqmerd 330 Chloroflexus au...
YP_428377    256 IPSGSvDLDGMc-gGGFFRDSVVLVSGATGTGKTLMSTHFLNGGLqaGERCLLFAFEESrPQLFRNASGWgidfqaaeds 334 Rhodospirillum ...
CAJ72079     254 ISTGIpKLDAMldgKGYYRGSTILVSGTAGTGKTSLSAAFADAACrrGERCLYFAFEESpSQIIRNMGSIgmnlarwvkk 333 Candidatus Kuen...
CBX29867     256 IATGVpKLDTMldgKGFYRGSTILVSGTAGTGKTSLSATFADAAClrGERCLYFAFEESpSQIIRNMGSIgldltrwvkk 335 uncultured Desu...
ABY32480     266 ASTGIpGLDAMlepGGFHRGTSILVSGESGTGKTMITSSMIAAACarGERCMSFVFEESgDQIIRNARSIgldlarhvea 345 Methylobacteriu...
YP_095148    251 LSTGIkALDSMlgsKGYQTGSQIIISGRSGTAKTLFATSFAQSAVrqGRKVLFISFEESpNDLIRHVKSInidlmkyitk 330 Legionella pneu...
P74503       255 ITSGSeELDRMc-gSGFFRDSIILVSGATGTGKTLMVTEFMDGGVanGERCLVFAFEESrEQLIRNATGWgvdfkqmeke 333 Synechocystis s...
YP_427629    250 ISTGVaDLDAMlsgGGFHRGSSILVSGVAGSGKSSLAASFVDATCraGESVIYFSFEEShEQATRNMKSIgidlgqwmas 329 Rhodospirillum ...

Feature 1                                            #                                    #      
3JZM_A       342 nLLKIVCAypesaglEDHLQIIKSEINdfkPARIAIDSLSALargvsnnaFRQFVIGVTGYAKqeEITGLFTNTsdqfmg 421 Synechococcus e...
4O0M_A       342 gLLRIICAypesaglEDHLQIIKSEIAdfkPSRVAIDSLSALargvsnnaFRQFVIGVTGFAKqeEITGFFTNTtdqfmg 421 Thermosynechoco...
YP_001636853 331 gLLRVICNypevtslEDQLIFMKAEIDrfrPQRVAVDSLSALervatikgFREFVIGLTSFIKhqEMAGLYTATtptllg 410 Chloroflexus au...
YP_428377    335 gQLRVVCDypevasiEDHLIKIKEEIDtfhPHRVAVDSLSAIaricsergFREFVIGLTSFIKhqEVAALFTSNtptlmg 414 Rhodospirillum ...
CAJ72079     334 gLLKFHSArpslyglEMHLVTFHKVINefnPQVFIVDPISNLsaagkaseVKSILTRLIDYLKmkKISTFLTDLthfg-g 412 Candidatus Kuen...
CBX29867     336 gLLKFYSArpslyglEMHLLTFHKVIEefdPQVFIVDPISNLssagtaaeVKSILTRLIDFTKmkKISTFLTDLthft-g 414 uncultured Desu...
ABY32480     346 gLLRFEAArpslyglEMHLARMHRDIDrfaPTVVVVDPLSALrgp--paeLQATMLRMVDMLKsrGITAVFTSLredg-s 422 Methylobacteriu...
YP_095148    331 kKLHINSRrsvemglEDHIISIIELTEekqFDVLILDPISALldlgntmeVKRLFIRFISYMKslNKTLLFTELipd--y 408 Legionella pneu...
P74503       334 gKLKVVCRypettnlENHLIMMKDIIQefkPNRVAVDSLSALervstlksFREFIIGLTSFIKqqEIGGLFTSTtpnllg 413 Synechocystis s...
YP_427629    330 gQLKYIATrptfyslEMHLAIVLREVIklkPSLVILDPISAFtesgerleVQGMLLRIVDFLKsrGVTGVFTHLmqsg-d 408 Rhodospirillum ...

Feature 1                                     #                    ##       
3JZM_A       422 ahSITDSHIXAITDTIILLQYVEirgeMSRAINVFKMRGSWHDKAIREFMISdKGPDIK 480 Synechococcus elongatus PCC 7942
4O0M_A       422 snSITESHIXXITDTILLLQYVEirgeMSRAINVFKMRGSWHDKGIREYVITeKGAEIR 480 Thermosynechococcus elongatus BP-1
YP_001636853 411 gsSVTEAHISTITDSIILLRYVElfgeMRRGLTVLKMRGSGHDKDIREFTIDsRGMHIG 469 Chloroflexus aurantiacus J-10-fl
YP_428377    415 gsSVTEAHISSITDSIILLRYVEtfgeISRGVMVLKMRGSRHEKEIREFAIDaTGMHIG 473 Rhodospirillum rubrum ATCC 11170
CAJ72079     413 slEHTSEEISSLIDTWLLLRDIElngeRNRGIYILKSRGMAHSNQIQEFLLTnQGIDLI 471 Candidatus Kuenenia stuttgartiensis
CBX29867     415 slEHTSEEISSLIDTWLLLRDIElngeRNRGLYILKSRGMAHSNQIQEFLLTnHGISLI 473 uncultured Desulfobacterium sp.
ABY32480     423 ldHDSNIGVSSLMDAWIKLLNIEangeRSRTLYVIKARGMRHSNQVREFSMSgDGITLV 481 Methylobacterium extorquens PA1
YP_095148    409 skELTILGLSSLTETWIRLSNVEsngeFNRLIHIAKARGIKTSNQIKEFYVTdKGINIE 467 Legionella pneumophila subsp. pneumo...
P74503       414 gaSITDAHISTITDSIILLRYVEmygeMRRGITVLKMRGSMHDKDIREFSIDhQGMHIG 472 Synechocystis sp. PCC 6803 substr. K...
YP_427629    409 nlIKTDAGLSSLMDAWILLLNREvngeFNRELYLLKARGMEHSNQVREFVMSrSGISLL 467 Rhodospirillum rubrum ATCC 11170

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