1Q57,5IKN,1CR0,1E0J


Conserved Protein Domain Family
RecA-like_Gp4D_helicase

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cd19483: RecA-like_Gp4D_helicase 
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RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase
This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
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PSSM-Id: 410891
Aligned: 64 rows
Threshold Bit Score: 175.451
Created: 8-Aug-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingheptamerhexamer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              ##                                        
1Q57_A       245 IMVTSGSGMVMSTFVRQQAlqwgtamgkKVGLAMLEESVEetaedliglhnrvrl-----------rqsdslkreiieng 313 T7
1E0J_B        48 IMVTSGSGMGKSTFVRQQAlqwgtamgkKVGLAMLEESVEetaedliglhnrvrl-----------rqsdslkreiieng 116 Enterobacteria ...
AUR99136     317 ITLASGVGLGKTYLANTISawfnkqhaiKSGMIMLEQPAEesgraivgsmtg-----------------qqfnnpkipmn 379 Vibrio phage 1....
APW79707     387 SVWGAGTGVGKTEITTQHItsli-kqgkPVVAIYLENSPEevlkmvasqmankdfmsp-----plgdgdeydasrdytqe 460 Pectobacterium ...
ARB10929     377 IIVGAGSGVGKTEFLREVAkhlieehgeSVGVISTEDPFKkvsrafigkwidkrielpp---tndptddgyrevfdyske 453 Pectobacterium ...
ASD54010     325 ITIGGAEGGGKTTLSRQIVhhnitkhdwGVFTAYMEETPTetlrrmaglndnlpy------------wepaftredpryd 392 Escherichia pha...
YP_008051088 308 YYFGSGVKMGKSVVVDQMAaffaatqdtPVMLVKPEESVPntlkrlagkaar-----------------kvlwdpkvpye 370 Pseudoalteromon...
ARB11234     388 HVWGAGTGVGKTDTTVAHVanlm-eqgeDVVVIYLENQSDevartfagmlvgkdfnsppqeqweidmgldenparqytqe 466 Marinomonas pha...
BAQ84665      64 VLLGGYSGHGKSAVANQLAlhaa-sldyKVGIASLELPAEyvfdqmagv-----------------------agcikeph 119 uncultured Medi...
ARM70562     319 ISVGGGTGCGKTLIAHELMawnivthdwKILAIMLEETPEetyqnvagkidnvpy-----------hvpladgetprnkq 387 Shewanella phag...
Feature 1         ##  ##  #  # #####                 #  ## #                                     
1Q57_A       314 kFDQWFDELFGNDTFHLYDsfae-----aetDRLLAKLAYMRSglgcDVIILDHISIVVSasgesd---erkmidNLMTK 385 T7
1E0J_B       117 kFDQWFDELFGNDTFHLYDsfae-----aetDRLLAKLAYMRSglgcDVIILDHISIVVSasgesd---erkmidNLMTK 188 Enterobacteria ...
AUR99136     380 kERLADAIDKVGDDFYFYDavrn-----adwDEIKPVIRHWVLvegvKIIQLDNLTTLTAhldsas---anqeinRIMAE 451 Vibrio phage 1....
APW79707     461 eLDATIDDLVATGLLIIPDlegs-----kdvNVIMEVLEDALAlg-yQYYVIDNLTAFEHyvdgkvq-vgvaaidETMKR 533 Pectobacterium ...
ARB10929     454 dADAAIDYVADTGKFFVADlegd-----ysmEKIEQTCLEFEAmg-iQNIIIDNLTGIKLderqfgg--kvgaldECVKR 525 Pectobacterium ...
ASD54010     393 eAKFRQTAAKMLRNMEIWDrkqagedpyetwDGLKTILRQIGPd--iDMFVLDNLTYLSEgisase---kndflgKLYAD 467 Escherichia pha...
YP_008051088 371 kEDFDKGKAIIGSNAIVFDsyqe-----irwADVKKEIRTNVEvcgvKDVFLDPLTCFTVgmpmsv---aneeliSIASE 442 Pseudoalteromon...
ARB11234     467 dLDDALTQLAESDRLRIADldgs-----kdvESVLEVMQECLAlg-yQYFVVDNLTAFEHkddrgnaskgvnaidETMKR 540 Marinomonas pha...
BAQ84665     120 eHWLRRFGYWANPRIFFYDrvds-----vtpDECLQMIIGMRKfhgcDLVVLDALMMVGLgddl-------eqekLFTQR 187 uncultured Medi...
ARM70562     388 vLANTVHRIASNLDVWDITtveds---ettwNQIQDVLRVSGDk--yDMVVIDNATVLSEglsssd---rndflgKVNAE 459 Shewanella phag...
Feature 1                                                                                        
1Q57_A       386 LKGFAkstgvVLVVICHlknpdkgkah--eegrpvsitDLRGSGALRq-lSDTIIALERNqqgdm----------pnlvL 452 T7
1E0J_B       189 LKGFAkstgvVLVVICHlknpdkgkah--eegrpvsitDLRGSGALRq-lSDTIIALERNqqgdm----------pnlvL 255 Enterobacteria ...
AUR99136     452 LAMMCkkyefSAFVYSHlnppktgdah--eeggevketQMTGSRGAMr-ySSYVLGFERNrnaglsp------eeqnlsR 522 Vibrio phage 1....
APW79707     534 IGTFKdehdvNIMLLTHlsrpekgrdp-helggevyitDLRGAGSISf-wANGVWGIERNtqaeai-------sdkcttL 604 Pectobacterium ...
ARB10929     526 IGTIKdrhavTIFLVSHltrvggqrts-heeggdvilsDFRGSGAIGf-wASYALGIERNtraetl-------dertttY 596 Pectobacterium ...
ASD54010     468 ITKLAdqyqfHVNILSHlnpvakgqrp-hedggrikksDFTGSRAAAk-ySHGMFGFERNsqavd----------pncsI 535 Escherichia pha...
YP_008051088 443 IATMAkeldfTAYLFCHlnapqsglph--erggavqsqQFSGSRAMMr-fCHQMWGLEGNkdpdlpd------elrncrD 513 Pseudoalteromon...
ARB11234     541 LGTFKdenpvNIMLLSHlvkvdaskriphtqggevyesDFRGAGSITf-wANAVWGIERNtrattm-------ynkcvtL 612 Marinomonas pha...
BAQ84665     188 LAEVAkafdvCVLLVAHlrkpaggeg----ekktpskfDFLGSSNILnvsSSAVLVHDMKekayarsqgeevddsygdtK 263 uncultured Medi...
ARM70562     460 FVKLAkkfnfMAMMFSHlnapgphqrs-henggrvlesQFTGTRAAMr-ySHMIFGFERNksaid----------pdcsY 527 Shewanella phag...
Feature 1              #   # #         #
1Q57_A       453 VRILKCRf-tGDTGIAGYMEYNK 474 T7
1E0J_B       256 VRILKCRf-tGDTGIAGYMEYNK 277 Enterobacteria phage T7
AUR99136     523 LRILKCRp-iGSTPGIVGLEFDI 544 Vibrio phage 1.262.O._10N.286.51.A9
APW79707     605 LRNLKSRgvgHKVGSTVVLRKDI 627 Pectobacterium phage PP99
ARB10929     597 ISCVKDRdqgIYTGTKVMLKGEM 619 Pectobacterium phage POP72
ASD54010     536 IRSIKARk-sGKTEGFKTYYDTE 557 Escherichia phage ST32
YP_008051088 514 LVLLEDRn-fGESGRIKMQYHST 535 Pseudoalteromonas phage RIO-1
ARB11234     613 YRNIKNRgigHMVGSTVAAVKDI 635 Marinomonas phage CPP1m
BAQ84665     264 FIVAKQRy-aPFEGVVHLYKHDK 285 uncultured Mediterranean phage uvMED
ARM70562     528 FVVLKNRk-fGRTGRFKTYYTKR 549 Shewanella phage SppYZU05

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