1YE8,2I3B


Conserved Protein Domain Family
RecA-like_Thep1

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cd19482: RecA-like_Thep1 
RecA-like domain of the nucleoside-triphosphatase THEP1 family
This family represents the THEP1 family ATPase domain. It includes nucleoside-triphosphatase THEP 1 from Aquifex aeolicus (aaTHEP1) a nucleoside-phosphatase, with activity towards ATP, GTP, CTP, TTP and UTP; and which may hydrolyze nucleoside diphosphates with lower efficiency. The catalytic function of aaTHEP1 remains unclear, it may be a DNA/RNA modifying enzyme. Human THEP1 (hsTHEP1) may have a general function in many human tissues, as it is widely expressed in most examined tissues (such as in brain, heart, lymph node, skin, pancreas); it is especially highly expressed in embryonic and various tumor tissues. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
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PSSM-Id: 410890
Aligned: 32 rows
Threshold Bit Score: 160.074
Created: 24-Apr-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATP
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ###                                                                    
1YE8_A         3 IIITGEPGVGKTTLVKKIVerl-----gkRAIGFWTEEVRdpetkkrtGFRIITt-eGKKKIFSskfftskk-----lvg 71  Aquifex aeolicus
2I3B_A         4 VFLTGPPGVGKTTLIHKASevlk--ssgvPVDGFYTEEVRqgg--rriGFDVVTl-sGTRGPLSrvglepppgkrecrvg 78  human
B2A6V4         6 ILLTGKPGIGKTTVIKRTVell-----scSSTGFYTREIKrgd--prvGFEIISlqtGERLPLAhtdfttaedrvgkygv 78  Natranaerobius ...
NP_649279      9 IILTGPPGVGKTTLVHKICsalq--drgrILQGFYTEEMRgegtsqriGFDVVTl-aGKRAILSrknpgdqlr--rpkvg 83  fruit fly
B1L726         7 FIIIGRPGSGKSTCIMLLLeklr--asgtKVGGIRTPELRerg--irkGFAVEDiltGQSDIFAstdfregp-----svs 77  Candidatus Kora...
NP_001032157   8 LLVTGPPGVGKTTLIMRVLdmmrvsnpnlKIQGFYTQEMRerg--qrvGFQVVTl-dGRTSLLAssivssqesmtwpsvg 84  thale cress
O27140         3 ILITGRPGSGKSTMVGRLRdyle--gmgfSVGGIITPEVRvgg--srwGFEVVDiasGRRGLLAsvetegp------rig 72  Methanothermoba...
Q8TKK3         4 IAVTGSPGVGKSTVVAKTAeklae-kpgfKIGGIRTAEIRkeg--hreGFSIRDlatGKTGILShvkgsgp------rlg 74  Methanosarcina ...
Q58954         3 IFITGMPGVGKTTLALKIAeklk--elgyKVGGFITKEIRdgg--krvGFKIITldtNEETILAyvgdgki------kvg 72  Methanocaldococ...
A1RYX5         6 FLLTGRPGIGKTTCVVKTAellv--srgvKVGGMVTHEVRegg--srvGFKVRDlltGREGFLAkvgagagp-----rvg 76  Thermofilum pen...
Feature 1                                          ##                                            
1YE8_A        72 sygvNVQYFEELAIPILERayreakkdrrKVIIIDEIGKXElfskKFRDLVRQIXHDpnvNVVATIPird---vhpLVKE 148 Aquifex aeolicus
2I3B_A        79 qyvvDLTSFEQLALPVLRNadcss-gpgqRVCVIDEIGKMElfsqLFIQAVRQTLSTpgtIILGTIPvpkg-kplaLVEE 156 human
B2A6V4        79 kaenLLGFLKEINEAMTSNk--------pQCLVIDEIGKMEfftpGFHETVDKAFQSs-yPLLATIMkksh--kfcDYLK 147 Natranaerobius ...
NP_649279     84 eysvFVQDFDSLALPVLGTqdsq---pepDLLVVDEVGKMEllskRFESAMADLLKKk-rALLVTIPeks---tlaLVEQ 156 fruit fly
B1L726        78 kyrvSVERFESIAIPALRRale-----ecEVVVIDEIGKMEllsrNFLEVVRDIWESe-iISVGTAPl-------vRIEE 144 Candidatus Kora...
NP_001032157  85 kykvDIASFESIALPELQVkd------dtNLFIIDEVGKMEmfspSFFPAVLNVLDSn-vPLLASIPspkfgrhlpEVAR 157 thale cress
O27140        73 rygvNVGVMDELAVPAIRRaml-----edDCIIIDEIGPMElksrEFRRTVDEVLSSd-vLLIAAVHr-------kTLQS 139 Methanothermoba...
Q8TKK3        75 kyhvNLDDLERIGANAVRNal------acDLVVIDEIGPMElisqSFVSAVEEVLESd-kPVLAVLHhss---rhpLAQR 144 Methanosarcina ...
Q58954        73 kyavFIENLDNVGVEAIKRalk-----daDIIIIDELGAMEfksrKFSEVVDEVIKSd-kPLLATLHr-------nWVNK 139 Methanocaldococ...
A1RYX5        77 kyvvHVEELEAVGVGAILRavs-----eaQVVVIDEIGPMElyspSFLPAVLKALDSd-kPVLATIHeres--ssgRLRG 148 Thermofilum pen...
Feature 1                                             
1YE8_A       149 IRRlp-gAVLIELtp----------eNRDVILEDILS 174 Aquifex aeolicus
2I3B_A       157 IRNrk-dVKVFNVtk----------eNRNHLLPDIVT 182 human
B2A6V4       148 NRGd---TDVIEVte----------nNRDDLPEKLAK 171 Natranaerobius thermophilus JW/NM-WN-LF
NP_649279    157 LRKsa-gSKIYQVtk----------fNRNALAGEITE 182 fruit fly
B1L726       145 IEKlkssSEVIIIergdserisnylfNRISDLLRVSR 181 Candidatus Korarchaeum cryptofilum
NP_001032157 158 LKNqp-gVNVISLsa----------tNRDPMKEHIFD 183 thale cress
O27140       140 IKKre-dIRVFVVdp----------eKRDRVYLRIID 165 Methanothermobacter thermautotrophicus
Q8TKK3       145 FRKg---FEVLTVdk----------gNRDELPEKITN 168 Methanosarcina acetivorans
Q58954       140 FKDk---GELYTLti----------eNREKLFEEILN 163 Methanocaldococcus jannaschii DSM 2661
A1RYX5       149 ILErg-dVKLYTVtl----------qNRDLLPPQLAR 174 Thermofilum pendens Hrk 5

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