4A60


Conserved Protein Domain Family
FABP9
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cd19471: FABP9 
fatty acid binding protein 9 and similar proteins
FABP9 (also known as testis-FABP, T-FABP, PERF15) is a major protein found in the inner acrosomal membrane and outer face of the nuclear envelope of mammalian sperm. Its expression is increased in prostate cancer. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Links
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Statistics
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PSSM-Id: 381246
Aligned: 3 rows
Threshold Bit Score: 242.955
Created: 4-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on FABP3 and other cytosolic fatty-acid binding protein family members with structure
  • Citation:PMID 7683727
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #           #  ##  # #   ##  #  # # # #      # # # # ## # # #       ##### #  
4A60_A        24 VEPFLGTWKLVSSENFEDYMKELGVNFAARNMAGLVKPTVTISVDGkMMTIRTESsFQDTKISFKLGEEFDETTADNRKV 103 human
AAB53798       2 IEPFLGTWKLVSSENFENYVRELGVECEPRKVACLIKPSVSISFNGeRMDIQAGSaCRNTKISFKLGEEFEETTADNRKV 81  house mouse
XP_001367150   2 LDPFLGTWKLVSSENFDNYLKELGMSFAARNVGGLAKPTVTISAKGeMFTIKTNM-VRTTEISFKLGEEFDETTADNREV 80  gray short-tail...

Feature 1                  # #          # #      # # #        # #  
4A60_A       104 KSTITLENGSMIHVQKWLGKETTIKRKIVDEKMVVECKMNNIVSTRIYEK 153 human
AAB53798      82 KSLITFEGGSMIQIQRWLGKQTTIKRRIVDGRMVVECTMNNVVSTRTYER 131 house mouse
XP_001367150  81 KSIITLENGTLVHVQKWQGKETTIKRKIVDGKMMVVCSMNNVVSTRIYEK 130 gray short-tailed opossum

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