Conserved Protein Domain Family
lipocalin_9

?
cd19429: lipocalin_9 
lipocalin 9
Lipocalin 9 (LCN9) is specifically expressed in the epididymis. It belongs to the lipocalin/cytosolic fatty-acid binding protein family. Lipocalins are typically small extracellular proteins that bind small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They are involved in many important functions, like ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior.
Statistics
?
PSSM-Id: 381204
Aligned: 5 rows
Threshold Bit Score: 277.491
Created: 11-Feb-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
ligand binding
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity binds different hydrophobic ligands; ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on lipocalin/cytosolic fatty-acid binding protein family members with structure

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    #   #                       # #       # # #          # # #        # 
Q9D267        21 HTAVRRDYNLARISGTWYLDSIASDNMTRIEENGDLRLFIRNIKLLnNGSLQFDFHFMLQGECVAVTMVCEKTkNNGEFS 100 house mouse
EAW88172      21 HTVMQRNYNVARVSGVWYSIFMASDDLNRIKENGDLRVFVRNIEHLkNGSLIFDFEYMVQGECVAVVVVCEKTeKNGEYS 100 human
EHB11625      21 EEIVEQDFNMTRAAGSWSSISLASDNVMWIGVNGDLHLFIRTIELLlNSSLLFHFRFWMQGECVFVTVVCEKTpKNAEFS 100 naked mole-rat
AAO50215      21 HTAVRRDYNLARISGTWYLDSIASDNMTRIEENGDLRLFIRNIKLLnIGSLQFDFHFMLQGECVAVTMVCEKTkNNGEFS 100 house mouse
NP_001100030  22 HIAVGKNYNMARISGVWHLVSMASDNMTYIEEKGDLRLFIRNIQFLnNSNLQFDFHIMIHGECVAVTVVCEKTkNSGEFS 101 Rattus norvegicus
Feature 1        #     # # #        # # #          # # #                                     
Q9D267       101 VAYEGKNKVLLLETDYsMYIIFYMQNIKNGTKTQVLALYGRSIlLDKTHQREFENICNLYGLDSQNIIDMTKKDFC 176 house mouse
EAW88172     101 INYEGQNTVAVSETDYrLFITFHLQNFRNGTETHTLALYETCE-KYGLGSQNIIDLTNKEPEPPRDTPLKAPLHFC 175 human
EHB11625     101 TVYRGENKVLILETDYwMYIIFYLRNVRFGIETQVLALYGRIPvLSDPLLDRFEKAYRKYGMGPRNTINLAEKDLC 176 naked mole-rat
AAO50215     101 VAYEGKNKVLLLETDYsMYIIFYMQNIKNGTKTQVLALYGRSIlLDKTHQREFENICNLYGLDSQNIIDMTKKDFC 176 house mouse
NP_001100030 102 IAYEGENKVLLVETDYtMYAIFHMQNIKNGTRTQVLALYGRFMqIDETYQERFENICKLYGLGSQNIIDMTNKDFC 177 Rattus norvegicus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap