4LLC,3KKB,4LLE


Conserved Protein Domain Family
KinB_sensor
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cd19409: KinB_sensor 
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ligand binding sensor domain of KinB and related sensor histidine kinases
The ligand binding sensor domain of KinB and related sensor histidine kinases forms a homodimer and binds to an as yet uncharacterized ligand, most likely via the dimerization interface, a feature that appears to be conserved in this domain superfamily. In the human pathogen Pseudomonas aeruginosa, quorum sensing has been shown to repress biofilm formation and virulence by activating expression of genes encoding the KinB-AlgB two-component system. The response regulator phospho-AlgB represses biofilm and virulence genes, while histidine kinase KinB dephosphorylates and thereby inactivates AlgB; the stimulus for KinB is as yet unknown.
Links
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Statistics
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PSSM-Id: 438627
Aligned: 25 rows
Threshold Bit Score: 96.1721
Created: 17-Jul-2018
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4LLC: Pseudomonas aeruginosa histidine kinase sensor domain KinB forms a homodimer, contacts at 4A
  • Structure:3KKB: Pseudomonas aeruginosa histidine kinase sensor domain KinB forms a homodimer, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #         #                                                           
4LLC_A         9 SHHYATIEVSQQLEQLLGDQLVILLREtpDGQALERSQNDFRRVLEQGRAntvdsAEQAALDGVRDAYLQLQAh----TP 84  Pseudomonas aer...
3KKB_A         9 SHHYATIEVSQQLRQLLGDQLVILLREtpDGQALERSQNDFRRVLEQGRAntvdsAEQAALDGVRDAYLQLQAh----TP 84  Pseudomonas aer...
4LLE_A         9 SHHYATIEVSQQLLQLLGDQLVILLREtpDGQALERSQNDFRRVLEQGRAntvdsAEQAALDGVRDAYLQLQAh----TP 84  Pseudomonas aer...
PZP24503      45 RSNFVVIEVAQQLRQNLGNQLALLLERpvQTQRLEQIRNDFQRTLDDAIKhnakgPDVEQLQLARDEFDAYNAfl--dQP 122 Pseudomonas cit...
WP_068828948  41 TRNLEIIEASLGLRQEMGSQVILLLRDhlDRQALKASDQRFRQWLQRAGAgaiepSDQQALAEIERAYEQFDQfl--dSP 118 Pseudomonas sp....
WP_015479761  47 QRNFDTIEVSQELRQALGDQLVQILSAepDNERLEAARRHFRDALERGQGraasdTEQQLLRQIADAHRQFVNas--eSP 124 Pseudomonas den...
KJS29734      45 RNNFAIIEINQQLRQTLGNHLIVMLTDsgRSEALEPLSQSFQQTLERGIAeasdeADRQAFQAVASAYASFLQqv--dSA 122 Pseudomonas sp....
PJI46185      47 QRNFDAIEVSQRLRQALGDELEQVLSArpNLEHLERARTHFAQALDQGRAlartsGERQAMTQIADAHRLFVEasdttGP 126 Pseudomonas sp.
GBL60143      45 SHNFATIASSQQLRQSLDDQLAQLLSDspDAQRLVLLREQFDRYLAEGRAkaasdVERTLYERIDQANQEFQGq----VS 120 Pseudomonas cit...
WP_011920487  45 QRGFTAVQIGQKLRQHLGDELILLIGQtpNPEALENIRQAFRSTLAEGFSaklgaDYVQGLEQAAILHRQMEQvaesaTP 124 Pseudomonas men...

Feature 1                   #  #   #       #          
4LLC_A        85 ALle--aPXADNDGFSEAFNGLRLRLQDLQQLALAGI 119 Pseudomonas aeruginosa PAO1
3KKB_A        85 ALle--aPXADNDGFSEAFNGLRLRLQDLQQLALAGI 119 Pseudomonas aeruginosa PAO1
4LLE_A        85 ALle--aPXADNDGFSEAFNGLRLRLQDLQQLALAGI 119 Pseudomonas aeruginosa PAO1
PZP24503     123 GQpl--qGFTGNPAFSKAYTQLRDHLVKMQQDALGDM 157 Pseudomonas citronellolis
WP_068828948 119 VTvr--rQLLEDDRFVLALQALRDRINAVQTRYVGAV 153 Pseudomonas sp. BMS12
WP_015479761 125 GPgr--pELLDDNDLSRNLDELRQQLLALHEFAMRNI 159 Pseudomonas denitrificans ATCC 13867
KJS29734     123 SNqn--lTLLEDNPLSQAFNQVRSLMTDMQRTAYDKI 157 Pseudomonas sp. BRH_c35
PJI46185     127 GRp----ALLEDSDLSRTLDVLRNRLLSLHQGAMENI 159 Pseudomonas sp.
GBL60143     121 SSgsnrwSLVVESDFSRTFTSLHQYLLALHNHAIQTI 157 Pseudomonas citronellolis
WP_011920487 125 AGqs-phNLAGNIPFTEAFQKLRNHLLDQQDRVVSWV 160 Pseudomonas mendocina

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