Conserved Protein Domain Family
TGF_beta_INHBB
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cd19405: TGF_beta_INHBB 
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins
INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.
Links
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Statistics
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PSSM-Id: 381675
Aligned: 7 rows
Threshold Bit Score: 228.276
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens INHBA (1NYS) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              ## #      
P09529       301 NLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGl-nPGTVNSCCIPTKLST 379 human
NP_001084055 264 NLCCRQQFYIDFRLIGWNDWIIAPAGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGl-nPGTVNSCCIPTKLST 342 African clawed ...
NP_571143    287 GLCCRQQFYIDFRLIGWNDWIIAPAGYYGNYCEGSCPAYMAGVPGSASSFHTAVVNQYRMRGm-sPGSVNSCCIPTKLST 365 zebrafish
P27093       285 NLCCRQQFYIDFRLIGWNDWIIAPSGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGl-nPGTVNSCCIPTKLST 363 chicken
XP_005990626 279 NLCCRQQFYIDFRLIGWNDWIIAPVGYYGNYCEGSCPAYMAGVPGSASSFHTAVVNQYRMRGm-sPGSMNSCCIPTKLST 357 coelacanth
XP_007894560 168 NLCCRQQFYIDFRLISWNDWIIAPTGYFGNYCEGRCPAYMAGAPGSASSFHTAVVNQYRMRGm-nPEAMHSCCVPTKLST 246 elephant shark
XP_007884319 286 SLCCRKEFYLDFRVIGWDDWIIAPVGYYGNYCVGSCPSHMAGAPGTASSFHTAVFNLYKVNGdssVSNLHSCCIPTRLNG 365 elephant shark

Feature 1                      #  ##        #
P09529       380 MSMLYFDDEYNIVKRDVPNMIVEECGCA 407 human
NP_001084055 343 MSMLYFDDEYNIVKRDVPNMIVDECGCA 370 African clawed frog
NP_571143    366 MSMLYFDDEYNIVKRDVPNMIVEECGCA 393 zebrafish
P27093       364 MSMLYFDDEYNIVKRDVPNMIVEECGCA 391 chicken
XP_005990626 358 MSMLYFDDEYNIVKRDVPNMIVEECGCA 385 coelacanth
XP_007894560 247 MSMLYFDDEYNIVKRDVPNMIVEECGCT 274 elephant shark
XP_007884319 366 LSMLYFDGKQNIVKRDIPDMVVEECGCT 393 elephant shark

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