1M4U


Conserved Protein Domain Family
TGF_beta_BMP7
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cd19397: TGF_beta_BMP7 
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.
Links
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Statistics
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PSSM-Id: 381667
Aligned: 7 rows
Threshold Bit Score: 236.865
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindingpolypeptideputative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #                                     # #                           #    
1M4U_L        33 DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAI 112 human
P30886       320 FLKQACKKHELFVSFRDLGWQDWIIAPEGYAAYYCDGECAFPLNSFMNATNHAIVQTLVHFINPETVPKPCCAPTQLNGI 399 African clawed ...
XP_005990644 316 DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNGYMNATNHAIVQTLVHLINPETVPKPCCAPTQLNAI 395 coelacanth
P18075       325 DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAI 404 human
NP_001070614 321 DQKQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCMGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLHAI 400 zebrafish
XP_007882729 178 EQQQACMKRELYVSFRDLGWQDWIIAPEGYAAYYCEGECSFPLNSYMNATNHAIVQTLVHLINPEKVPKPCCAPTQLNAI 257 elephant shark
XP_417496    359 DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAI 438 chicken

Feature 1                              ##   
1M4U_L       113 SVLYFDDSSNVILKKYRNMVVRACGCH 139 human
P30886       400 SVLYFDDSANVILKKYKNMVVQACGCH 426 African clawed frog
XP_005990644 396 SVLYFDDSSNVILKKYRNMVVRACGCH 422 coelacanth
P18075       405 SVLYFDDSSNVILKKYRNMVVRACGCH 431 human
NP_001070614 401 SVLYFDDSSNVILKKYRNMVVRACGCH 427 zebrafish
XP_007882729 258 SVLYFDDSSNVILKKYRNMVVRACGCH 284 elephant shark
XP_417496    439 SVLYFDDSSNVILKKYRNMVVRACGCH 465 chicken

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