5E4G


Conserved Protein Domain Family
TGF_beta_GDF11
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cd19389: TGF_beta_GDF11 
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins
GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.
Links
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Statistics
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PSSM-Id: 381659
Aligned: 7 rows
Threshold Bit Score: 222.988
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens myostatin (5F3H) forms a homodimer.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           # # #  # # #      # #####       ## ### ###  ## ##### ####  # 
5E4G_A         1 NLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMS 80  human
O95390       299 NLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMS 378 human
OCA46442     175 NLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMS 254 western clawed ...
XP_014353443 226 NLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMS 305 coelacanth
KFP05980     123 NLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMS 202 Anna's hummingbird
AJG06061     281 NLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQHANPRGSAGPCCTPTKMS 360 zebrafish
XP_007888340 278 NLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFLQKFPHTHLVQQANPRGSAGPCCTPTKMS 357 elephant shark

Feature 1           # #           #### #     #
5E4G_A        81 PINMLYFNDKQQIIYGKIPGMVVDRCGCS 109 human
O95390       379 PINMLYFNDKQQIIYGKIPGMVVDRCGCS 407 human
OCA46442     255 PINMLYFNDKQQIIYGKIPGMVVDRCGCS 283 western clawed frog
XP_014353443 306 PINMLYFNDKQQIIYGKIPGMVVDRCGCS 334 coelacanth
KFP05980     203 PINMLYFNDKQQIIYGKIPGMVVDRCGCS 231 Anna's hummingbird
AJG06061     361 PINMLYFNDKQQIIHGKIPGMVVDRCGCS 389 zebrafish
XP_007888340 358 PINMLYFNGREQIIYGKIPAMVVDRCGCS 386 elephant shark

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