5FFO,3RJR,1KLD


Conserved Protein Domain Family
TGF_beta_TGFB1
?
cd19384: TGF_beta_TGFB1 
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.
Links
?
Statistics
?
PSSM-Id: 381654
Aligned: 9 rows
Threshold Bit Score: 188.539
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 39 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1KLD; Homo sapiens TGF-B1 forms a homodimer, contacts at 4A.
  • Citation:PMID 8679613
  • Structure:5FFO; Homo sapiens TGF-B1 forms a homodimer, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1              ### # ### #        # #####          ### ### ##  ##   ### ####  #          
5FFO_D       265 NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 344 human
3RJR_A       265 NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 344 pig
1KLD_A        14 NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 93  human
P01137       292 NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 371 human
P16176       284 NCCVKPLYINFRKDLGWKWIHEPKGYEANYCLGNCPYIWSMDTQYSKVLSLYNQNNPGASISPCCVPDVLEPLPIIYYVG 363 African clawed ...
P09531       275 NCCVRPLYIDFRKDLQWKWIHEPKGYMANFCMGPCPYIWSADTQYTKVLALYNQHNPGASAAPCCVPQTLDPLPIIYYVG 354 chicken
O93449       284 SCCVRKLYIDFRKDLGWKWIHEPTGYFANYCIGPCTYIWNTENKYSQVLALYKHHNPGASAQPCCVPQVLEPLPIIYYVG 363 rainbow trout
ADH10175     165 NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVG 244 Schistosoma jap...
XP_007883723 311 ECCLRNLYVDFRKDLGWKWIHEPKGYRANLCAGPCPYLWSSDTMHGKVLNLYSSRNPQASPAPCCVAQDLNPLAVVYYVG 390 elephant shark

Feature 1               ######     #
5FFO_D       345 RKPKVEQLSNMIVRSCKCS 363 human
3RJR_A       345 RKPKVEQLSNMIVRSCKCS 363 pig
1KLD_A        94 RKPKVEQLSNMIVRSCKCS 112 human
P01137       372 RKPKVEQLSNMIVRSCKCS 390 human
P16176       364 RTAKVEQLSNMVVRSCNCS 382 African clawed frog
P09531       355 RNVRVEQLSNMVVRACKCS 373 chicken
O93449       364 RQHKVEQLSNMIVKSCRCS 382 rainbow trout
ADH10175     245 RKPKVEQLSNMIVRSCKCS 263 Schistosoma japonicum
XP_007883723 391 RTAKVAQLSDMSVKTCQCR 409 elephant shark

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap