Conserved Protein Domain Family
TGF_beta_GSDF

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cd19379: TGF_beta_GSDF 
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins
GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.
Statistics
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PSSM-Id: 381649
Aligned: 20 rows
Threshold Bit Score: 89.3443
Created: 25-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens TGF-B1 (1KLD) forms a homodimer.
  • Citation:PMID 8679613

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ###   ## #         # #####                                       ####  # 
NP_001108140  83 SSCCRRSSQVLMKDLGWdGWVVLPeSVAFVQCVS-CGSgt-----------------------------svQCCKPTAHh 132
XP_007909244 118 RDCCQTVSISLTDLGWE-NWIIHPeEFPYILCTN-CRAgrnsqsphcth------------dqqrhtarkaKCCRNNRRt 183 elephant shark
XP_025024694 211 GGCLQISQHITLDDLGWqSWVLSPkSFIFTECLG-CHChrkreetqlhfwsrac-glqqpshqayadaqqrRCCRPQKTl 288 Burmese python
CCP19133     135 KHCCQITTEIFITELGWeNWLIYPeAITYTDCVS-CRYardvvsrdcrqe----------rmiarpkqakpRCCKAVREe 203 Menado coelacanth
AWT24641     132 RTCCQVTSEIFIQDLGWqSWIIYPeSFSYSECVD-CTTalstaplqcrq-----------ellsadismkeYCCKAKNEi 199 West African lu...
ANA50862      42 PHCCQITSQIFITDLGWeSWIVYPeSFNYTQCEA-CNHgrsrtwqhcrqg----------gpsakhhvpkvKCCSAVEEl 110 sterlet
XP_015928401 262 NDCCLESFFVTVEELGWeAWVHQPlIFNIGDCVGhCTDthtyyksqyqtirntlskinsthfqrpacafwtPKCKPTQLv 341 common house sp...
XP_788027    394 PGCCRRTMDVSFSDLGWsWMVAPR-RLTTSVCIGsCLApnmtfesfmvnl---------mqghgrpssrdeRRCRPSRTd 463 purple sea urchin
BAQ19197     297 ISCCREPVLFNFEEAGL-GWIIAPtGFYTSECAGsCHAhngvrts--------------------sgmtieHSCRPNNRk 355 owl limpet
AEP16387     192 EKCKLEPLYINFRDLGWeSWVIAPpGLEVGSCSGyCMRedissnynllinnisr-dpelyrlyglagirteRTCVPTSFl 270 sea walnut
Feature 1                          #####     
NP_001108140 133 iVPFVYMDAs-GLVLs--TVRLPRDCGC 157
XP_007909244 184 wVSVVYIDAdeGLVTs--NVPLTARCSC 209 elephant shark
XP_025024694 289 -VPFVFLKEdgSLNIq--TVRLTHECHC 313 Burmese python
CCP19133     204 wITFIYLDNy-SLIMe--NVPLTRECGC 228 Menado coelacanth
AWT24641     200 lVPFVYLEEdsSLVIr--NVPFIQECEC 225 West African lungfish
ANA50862     111 wLRFVYIDEdsPLVIs--NVPLTQKCGC 136 sterlet
XP_015928401 342 aQNIMYDNNgtIIYDt-iPSMVIESCQC 368 common house spider
XP_788027    464 hFDALVINEdgDIQMmrlPDFIVRECAC 491 purple sea urchin
BAQ19197     356 pLSVLYITKslNIRLgllPGIVVMDCSC 383 owl limpet
AEP16387     271 pTVLMFIGKdqDIVVqlvDDILVGGCGC 298 sea walnut

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