3OOI


Conserved Protein Domain Family
SET_NSD1
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cd19210: SET_NSD1 
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.
Links
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Statistics
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PSSM-Id: 380987
Aligned: 7 rows
Threshold Bit Score: 313.788
Created: 11-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 39 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                #         #   #        #######                ####
3OOI_A         91 YPEVEIFRTLqRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEhdiTNFYMLTLDkDRIIDAGPKGNYARFMN 170  human
XP_005992405 2193 YPHVEIFRTMgRGWGLCSKVDLKKGEFVNEYVGELIDEEECRARIKHAQEndiSNFYMLTLDkDRIIDAGPKGNHARFMN 2272 coelacanth
XP_007908405 1356 YPEVEILKTPgRGWGLCCKGDIKKGQFVNEYVGEVIDEEECYSRIKYAQEhdiCNFYMLTLDkDRIIDAGPKGNYSRFMN 1435 elephant shark
Q96L73       1941 YPEVEIFRTLqRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEhdiTNFYMLTLDkDRIIDAGPKGNYARFMN 2020 human
XP_018107724 1763 YPEVEIFRTLsRGWGLRCKTDIKKGEFVNEYVGEMIDEEECRARIRYAQEhdiTNFYMLTLDkDRVIDAGPKGNFARFMN 1842 African clawe...
KFO91035      286 YPEVQIFRTLaRGWGLQAKTDIRKGEFVNEYVGELIDEEECRARIRYAQEhdiTNFYMLTLDkDRIIDAGPKGNYARFMN 365  Buceros rhino...
KKF23712     2026 YSQVEIFRTLsRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQEndiCNFYMLTLDkDRIIDAGPKGNEARFMN 2105 large yellow ...

Feature 1         #      ###              #          ########### #####        # 
3OOI_A        171 HCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 232  human
XP_005992405 2273 HSCQPNCETQKWTVNGDTRVGLFALCDIPAGSELTFNYNLECLGNGKTVCKCGSPNCSGFLG 2334 coelacanth
XP_007908405 1436 HSCKPNCETQKWTVNGDTRVGLFALCEILSGSELTFNYHLECLGTGKTACKCGAPNCSGYLG 1497 elephant shark
Q96L73       2021 HCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 2082 human
XP_018107724 1843 HCCQPNCETQKWTVNGDTRVGLFALCDVKAGIELTFNYNLECLGNGKTVCKCGAPNCSGFLG 1904 African clawed frog
KFO91035      366 HCCQPNCETQKWCVNGDTRVGLFAIVNIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 427  Buceros rhinoceros silvestris
KKF23712     2106 HCCQPNCETQKWTVSGDTRVGLFALVDVPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLG 2167 large yellow croaker

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