Conserved Protein Domain Family
SET_KMT2B

cd19207: SET_KMT2B

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins

KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.

Links

Source:	cd19170
Taxonomy:	Sarcopterygii
PubMed:	6 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl40432

Statistics

PSSM-Id:	380984
Aligned:	3 rows
Threshold Bit Score:	300.017
Created:	12-Jun-2018
Updated:	2-Oct-2020

Structure

Conserved Features/Sites?
PubMed References ?

putative activeZn binding site putative SAM putative catalytic

Feature 1:putative active site [active site]

Evidence:

Comment:Based on the structure evidence that Homo sapiens mixed-lineage leukemia protein MLL1 binds cofactor product S-adenosylhomocysteine and histone peptide through its SET domain.
Citation:PMID 19187761

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1                               ####                #                        ######       
Q9UMN6       2562 MAMRFRHLKKTSKEAVGVYRSaIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDdFDVVDA 2641 human
AAI59185     1469 MAMRFRHLKKTSKEAVGVYRSaIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDdFDVVDA 1548 western clawe...
XP_014345820  242 MAMRFRYLKKTSKEAVGVYRSaIHGRGLFCKRNIDAGEMVIEYSGTVIRSVLTDKREKYYDSKGIGCYMFRIDdFDVVDA 321  coelacanth

Feature 1               ######       ###        #               ######        ####        # 
Q9UMN6       2642 TMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPiedasnKLPCNCGAKRCRRFLN 2715 human
AAI59185     1549 TMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRSIYRGEELTYDYKFPiedasnKLPCNCGAKKCRRFLN 1622 western clawed frog
XP_014345820  322 TMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPiedasnKLPCNCGAKRCRRFLN 395  coelacanth

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

| Disclaimer | Privacy statement | Accessibility |

Conserved Protein Domain FamilySET_KMT2B

Conserved Protein Domain Family
SET_KMT2B