2MPL


Conserved Protein Domain Family
PR-SET_ZFPM
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cd19201: PR-SET_ZFPM 
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins
ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.
Links
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Statistics
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PSSM-Id: 380978
Aligned: 18 rows
Threshold Bit Score: 105.505
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative activeputative SAMcatalytic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             ##                #                         
2MPL_A          2 WSGPEELELALQDg----------------------QRCVRARLsLTEGLSWGPFYGSIQTralspereepg-------- 51   house mouse
XP_002604975   13 GSLPGCLQIEEKEg----------------------HVSLTAREeLPDGMRWGPYGGVVIGgeekdpqkglkvpc----- 65   Florida lancelet
Q8WW38         97 WDGPGELEVFQKDg----------------------ERKIQSRQqLPVGTTWGPFPGKMDLnnnslktkaq--------- 145  human
XP_013389666   52 LCIPTDILRLDDSadn------------------ggSRSILTAMaLPEGSSFGPYEGRVVAegedmqgepqskvqfl--- 110  Lingula anatina
XP_022239094   23 LQLPTDVFAIKESkdg-----------------ditVQTVYTKEpLTKGTAFGPYKGRIAKqnsfyskklytddnd---- 81   Atlantic hors...
ELU06198       31 HDLPSDFRLRHPDsqar---------------tsttEYGVFASRtILEGTTFGPYTTKLIQedgidtgeytvelpea--- 92   Capitella teleta
XP_023229043   27 LKLPTDVLEIRESqqa------------------dvDYIVCSHVtIREGTLFGPYGGHIVAdvdnnhknnvleard---- 84   bark scorpion
XP_015788380   48 DNLPKSLELRPPPqlqsscssssltnqsdpvsgsprLVTVTTKVdLRSGHRFGPFPGKITKdpvpqsynwkvtdig---- 123  two-spotted s...
XP_022247288   45 QFLPEELQFKPSSls--------------------yQIGVWTRNkINKRSRFGPILARLETtrtsklswkvveqcg---- 100  Atlantic hors...
XP_006824276  648 LDLPRELTLKIDEq---------------------lQISVWTKQdITNDTEFGPYQGKLTMkfmpaesrdkwlvtgpnyd 706  Saccoglossus ...

Feature 1                             ##### #         ##                         #     
2MPL_A         52 -------pavtlmvdesCWLRMLPQVLTEe-aANSEIYRkd--dALWCRVTKVVPsGGLLYVRLVTEPH 110  house mouse
XP_002604975   66 ---degegftvvlgdpsHWLLMLPPASSSg-eHNTTICTqd--gSIWCVVTRTVApGEALQVHGLQEAD 128  Florida lancelet
Q8WW38        146 --------vpmvltagpKWLLDVTWQGVEdnkNNCIVYSkg--gQLWCTTTKAISeGEELIAFVVDFDS 204  human
XP_013389666  111 -salgtvvkvelfgsegGWLQHVRSPDTTd-tENLAITYkg--gQIWCELTKPVEeNETLIGIFQPSSP 175  Lingula anatina
XP_022239094   82 --sneeeiilqidgengLWLKLLKVAINPe-eANIIITReg--nSIWCTMNCDVGkDEELTVWCEISSP 145  Atlantic horseshoe crab
ELU06198       93 -sntggrdllclvedksRWIRLILTDQDPn-sSNAVIKItg-pdEIVCIITKEIPtDTELVAMLDRDVS 158  Capitella teleta
XP_023229043   85 --kegrkvhilprndscAWLKIVRTASSAl-eANLNVLMdg--eEIWCTVSCDIPpNIELKAWYTIRND 148  bark scorpion
XP_015788380  124 --rsltawlqlndfdslKWITCFRCAERQt-dQNAILLLfr--gQLFIEILKDILpGKELLLVFNEVLL 187  two-spotted spider mite
XP_022247288  101 ---klrgwlctatrpsgHWTNLVRRADDMv-aSNTCLVYen--gKLYLEVSIPLEeSTELIISAAEMIL 163  Atlantic horseshoe crab
XP_006824276  707 svamfqplddleaelppNWLRYISPASSDq-dQNCVLTRteedtRYMIKIVGDIApNQELFAVHNEEFL 774  Saccoglossus kowalevskii

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