5ECJ


Conserved Protein Domain Family
PR-SET_PRDM14
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cd19198: PR-SET_PRDM14 
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins
PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.
Links
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Statistics
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PSSM-Id: 380975
Aligned: 11 rows
Threshold Bit Score: 248.082
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:ETO-family corepressor, myeloid translocation gene related 1 (Mtgr1) binds tightly to the pre-SET/SET domains of Prdm14
  • Structure:5ECJ; Mus musculus PRDM14 binds ETO-family co-repressor Mtgr1, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #                                 ##   #######     ##   #          
5ECJ_A        56 LQLPEGLCLMQtsFGDVPHFGVFCSDf-IAKGVRFGPFRGRVVNASEVKahrDNSRMWEIFE-DGHLSHFIDGkg-sGNW 132 house mouse
PFX27141     162 LYLPQGIRVLN--KGPHQFAVVSCRAs-ISKGTRFGPYRGRVIQPSQVKegeDNAYLWEVCKeDGSLAYYIDGlpetENW 238 Stylophora pist...
CEP16118     222 LDMPEGVELVHtnFAGTIHYGVFVKKtvIPKGTRFGPFRGRQVNTSEIKtndDNSFMWEVFA-KGQLSHFVDGrgsaGNW 300 Dumeril's clam ...
OCT76895     212 LQLPEGLTVLDtsYGTLPKSGVFCKNl-IPKGAKFGPFQGKVVHPSEIKtygDNSLMWEIFN-EGRLSHFIDGkgsaGNW 289 African clawed ...
Q9GZV8       247 LQLPEGLCLMQtvFGEVPHFGVFCSSf-IAKGVRFGPFQGKVVNASEVKtygDNSVMWEIFE-DGHLSHFIDGkggtGNW 324 human
ESO83688     147 LDLPEGIVVHQtgFAGTLHHGVFCAKtvISKGVRYGPFKGRVVNTSEIKtndDNSFMWEVFQ-EGKLSHFIDGrgstGNW 225 owl limpet
KFP08168      20 LKLPEGLSVLRvaYGEVSQLGVFCTNp-IPKGIRFGPFQGKVVNTSEIKtydDNSLMWEIFE-HGRLSHFIDGkgasGNW 97  Anna's hummingbird
XP_014353634 213 LELPEGLSVFQtvYSGVPLYGVFCTKv-IPNGVRFGPFKGKVVNTSEIKtydDNSLMWEIFE-DGRLSHFIDGrgvsGNW 290 coelacanth
XP_013402611 168 LDLPDGIAIFQtsFAGTVHYGVFCQKtvIAKGTRYGPFQGKIVNTSEIKshdDNSFMWEIFQ-EGKLNYFVDGrgsaGNW 246 Lingula anatina
XP_002739286 182 FDIPEGIAIYQttFAGCMHYGVFCNKdvIPKGTRFGPFVGRTVHTSEIKtndDNTHMWEIFK-DGKLSHFIDGrgssGNW 260 Saccoglossus ko...
XP_019632785 224 LDLPEGLGFFQtrFSSTKHFGVYCKQvaLPKGTRFGPFVGKVVNISEIKtddDNSHMWEIFQ-DGKLSHMIDGrgptGNW 302 Belcher's lancelet

Feature 1             ###### #                           ## # ##########
5ECJ_A       133 MSYVNCARFPKEQNLLAVQHQGQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMN 187 house mouse
PFX27141     239 MKFINCARNNEEQNLVLIQDGEQLFYESCREILYGEEMMVWYGNRYHMFMGIPIG 293 Stylophora pistillata
CEP16118     301 MAYVNCARYAQEQNLLALQCEDLIYYEACKDIPQGTELLVWYGDCYLQFLGIPVA 355 Dumeril's clam worm
OCT76895     290 MTRVNCARFPEEQNLIALQCDGEIYYESCKEILPGQELLVWYGDGYLQFLGIPLS 344 African clawed frog
Q9GZV8       325 MSYVNCARFPKEQNLVAVQCQGHIFYESCKEIHQNQELLVWYGDCYEKFLDIPVS 379 human
ESO83688     226 MSCVNCARYAQEQNLIAVQHEGEIYYEVCKDIPQGTELLVWYGDCYLQFMGVPVA 280 owl limpet
KFP08168      98 MSLVNCARFPEEQNLTAIQCQGQIFYESCKEILPKQELLVWYGDCYVQFLGIPIS 152 Anna's hummingbird
XP_014353634 291 MALVNCARFPEEQNMTAVQSQGQIYYETCKEILPKQELLVWYGDCYLQFLGIPLS 345 coelacanth
XP_013402611 247 MAYVNCARYAQEQNLIAIQNDKEIFYEACKDIPQGTELLVWYGDCYLQFMGIPVA 301 Lingula anatina
XP_002739286 261 MSYVNCARYAQEQNLLAIQSDGEIMYETCKDIPRGQELLVWYGDCYLQFMGIPVA 315 Saccoglossus kowalevskii
XP_019632785 303 MAYVNCARYAQEQNLIAIQCEGQIYYEACKEIPQGAELLVWYGDCYLQFMGIPVA 357 Belcher's lancelet

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