Conserved Protein Domain Family
PR-SET_PRDM13

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cd19197: PR-SET_PRDM13 
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins
PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.
Statistics
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PSSM-Id: 380974
Aligned: 8 rows
Threshold Bit Score: 162.296
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeputative SAMcatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #   ##                   #                                ##### #       
Q9H4Q3        18 IPAGLRLGP---VPGTFKLGk--YLSDRREPGPKKKVRmvrge----------lvdesGGSPLEWIGLIRAARNSQEQTL 82  human
CEP16112      33 ISAGTVFGP---IPRNVTLTdpaYLIGHMTCDNHPDVHtvkldm---------tdyidGERAVEWVPYVKAARNTSEQNL 100 Dumeril's clam ...
KFO62271      14 IPAGLRLGP---VPGTFKLGk--YLSDRKEPGPKKKVFsyvspvfqvrmvrgelvdeaGSSALEWIGLIRAARNSQEQTL 88  American crow
EKC35319      39 ADCGTRYIRaicVPRRDQSLl--DKSLRLRFDLIVFDDrgeviy--------fvdggsDSHPTSWLSCVQCARTDREQNL 108 Pacific oyster
XP_006000293  17 IPAGMRLGP---VPGMFKLGk--YMSDRKDPGIKKKVRlvkgd----------lvdeaGAPVLEWIGLIRAARNNQEQNL 81  coelacanth
AQZ41242      17 IPAGLRLGP---IIGIFKLGk--YLSDRREPGPKKKVRfvrge----------lldesGGPATEWMGLVRAARNNHEQNL 81  African clawed ...
NP_001313383  17 IPAGLRIGP---VPGIFKLGk--YVSDRKELGVKKKIRlvrge----------fvdesGSAVPDWIGLIRAARNGQEQNL 81  zebrafish
XP_007891148  17 IPAGLRLGP---VQGIFKLGk--YMSDRKEQSNKKKVRfvrgd----------lvdeaGDPVPEWIELVRAARHNQEQNL 81  elephant shark
Feature 1         ##                         ## ##  ##
Q9H4Q3        83 EAIAdlpgGQIFYRALRDVQpGEELTVWYSNSLAQWF 119 human
CEP16112     101 EAYLr--dGQLHYRALHNIPtNRELFIWYSPSLASII 135 Dumeril's clam worm
KFO62271      89 EAVAdlpgGQIFYRALRDVQpGEELTVWYSNPLAQWF 125 American crow
EKC35319     109 EITQt--nTHIFYRAMKDIPpEEELLVWYGQNSVYHM 143 Pacific oyster
XP_006000293  82 EAIAdlpgAQVFYRALRDVQpGEELTVWYSNALAQWF 118 coelacanth
AQZ41242      82 EAISdlpgGQIYYRTLRDVQpGEELTVWYSSSLAHWF 118 African clawed frog
NP_001313383  82 EAVSdlpgGQIFYRVVREIQaGEELSVWYSNSLAQWF 118 zebrafish
XP_007891148  82 EAITelpgGQIFYRAMRDIQpGEELSAWYSSSLAQWF 118 elephant shark

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