4C1Q,4IJD


Conserved Protein Domain Family
PR-SET_PRDM7_9
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cd19193: PR-SET_PRDM7_9 
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins
PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.
Links
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Statistics
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PSSM-Id: 380970
Aligned: 25 rows
Threshold Bit Score: 169.337
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4C1Q; Mus musculus PRDM9 binds H3k4me2 and Adohcy through its PR-SET domain, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #  ###                 #                  ## #####               
4C1Q_A         46 VLSLPPGLRISPSg-IPEAGLGVWNEAsdLPVGLHFGPYEGQITEDee--------aANSGYSWLITKGr---------- 106  house mouse
XP_002130308  251 RKTSPDGISIAMSg-IRAGGLGAWCDKg-FSKNTVFGPYEGKAVHRndvak--lsrlFEGGYAWEIYKKg---------- 316  Ciona intesti...
XP_019853365  261 SVPVPRELTVKESk-IPKAGLGVFATEl-IPNGVKFGPYKGQKVYYedi-----dedDDTSYMWEIKKP----------- 322  Amphimedon qu...
XP_022195415   43 KETTPRILGVAQSk-IANAGKGVWTRDm-IKNQIQFGPYQGRTGKGs---------pKDPNYAWQLKEMa---------- 101  brown plantho...
XP_001641018  120 DVLVPPGLEVKESn-IPNAGRGVFAKCi-IPKHEFFGPYIGRIVTRkea-----ktyKESPYVWEVFDDy---------- 182  starlet sea a...
EKC33542      125 NLTTPPGFSVKLSs-IPGAGLGAWTSTh-LPINNVLGVYDGEEFIDd----------GEYMYGWMLDNVdg--------- 183  Pacific oyster
PAA57651      177 DLTLPDGMRICRSavGRHAGNGVWAEAp-IARGSIFGPYLGQRITDka-------taEASSYAWEIRRD----------- 237  Macrostomum l...
EKC41743      112 QLTTPPGFSIRRSl-IPRANMGVWTDAf-VPKHTILAEYEGEFVESp----------TDFTYCWQIDSG----------- 168  Pacific oyster
CDS28688      185 RRTAPECFVHVGQssIRGAGLGVWAEKe-IPIGAIFGPYTGEIVPLedildqelkkrSRLGYAWLVRGNhlgtkshlvda 263  Hymenolepis m...
PFX29580      678 RSTIPSSMDLKISs-IPDAGLGIFAKEr-FEADVVFGPYWGDKIDVadl-----tpnMDQSYMWDIIENg---------- 740  Stylophora pi...

Feature 1                #            ##### #        ##                       ## ##  ##   
4C1Q_A        107 ---NCYEYVDGQDesqaNWMRYVNCARDDeEQNLVAFQYHRKIFYRTCRVIRPGCELLVWYGDEYGQELGIK 175  house mouse
XP_002130308  317 ---KLSHYIDGEDtkqsNWMRYINCACFEeQQNVIAYQYQGDIYYRLYRDVTPGTELLVWYGDQYAQSLGIP 385  Ciona intestinalis
XP_019853365  323 ---NESYYIDGQVesesNWMRYINCARNEeEQNLVAFQYHGEIYYRTFKDICPGTELFVWYGDQYAKDLGIE 391  Amphimedon queenslandica
XP_022195415  102 ---GGLNYIDASDerysNWMRYVNCARNInEMNLMAYQFEGGIYYRTFRLVAPHEELFVFYGEQFGCSLGID 170  brown planthopper
XP_001641018  183 --gKLTHLIDGRDalqsNWLRYVNCSKGLdEQNLRAVQYDKNIYYMATKEIAIGEELLTYYGDKFAKKIGIK 252  starlet sea anemone
EKC33542      184 --eLATHFVDAGSpakgNWLRYVNCARNEqEENINVVFCEDLVFYITSKDIAPNTELLMWYGTWYGNLLGIK 253  Pacific oyster
PAA57651      238 ---KSCEWVDAADmrfsNWMRYVNCSRNLcEQNMIAFQWDNNVYYIAIRDISPDHELLVYYGDEMAKLYNIV 306  Macrostomum lignano
EKC41743      169 ---PHKLFIDGKNenisNWLRYVNCARNAfEENTDTFNCGSKKFYYTIKDVHPNNELLVWYGTSYGKWLDIE 237  Pacific oyster
CDS28688      264 fhpVLSNWLRVGLhmpkVNVQYVNCARHDeEQNLVTIQYRGKIYYRACQTIKPGYELLTYYGDKFAKELGII 335  Hymenolepis microstoma
PFX29580      741 ---RVTHVVDARGeehsNWLRFVNCARNEdEQNLVAFQFRGEIYYRSFKTIEPGMELLVWYGDKYACGPIQC 809  Stylophora pistillata

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