Conserved Protein Domain Family
SET_SpSET3-like
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cd19183: SET_SpSET3-like 
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins
Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.
Links
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Statistics
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PSSM-Id: 380960
Aligned: 8 rows
Threshold Bit Score: 222.664
Created: 21-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activeputative SAM
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ##                #         #             ########               
Q10362    215 VPISSSKFcc----sRFGLVSTCeIPPNTPIMEVkGRVCTQNEYKSDPKNQYniLGAPKPHVFFDSn--sQLVVDSRVaG 288  Schizosaccharomyc...
EJD34677  141 RKLQVQRVhy---agQYGLFARVrRERGDLLARFlAVVARGADYLADPTNMYpsLFLPKPYVHLLPapggPLVLDTRRaG 217  Auricularia delic...
CAF06059  285 IELSRKTLgqgtvasWKCLKAPSaIAHNVPLVELnGQIGIQSSYCADPDSRWqeLTSPLPYVFFHPm--lPIYIDTRKeG 362  Neurospora crassa
P36124    321 ADIAYSRTypg--ftKLGVYLKKdCIKGDFIQEIlGELDFYKNYLTDPRNHYriWGTAKRRVIFHSh--wPIYIDARLsG 396  Saccharomyces cer...
P42948    346 ADIEVRKSsn---erDFGVFAADsCVKGELIQEYlGKIDFQKNYQTDPNNDYrlMGTTKPKVLFHPh--wPLYIDSREtG 420  Saccharomyces cer...
EGX51648  275 EELSSIGLp------LIRLVADTpSKADQFVIEYvGEIGSKTSYIQDTLNQYgrIRHPKAFVLFHPq--lPIYIDARRcG 346  Arthrobotrys olig...
KTW28056  211 TSIQPTSNtnissllRFSLQSNQfIASGQIIREIkGEIYLQDEYKVNSINHYsfLLAPKPFVYFVSd--sKLCIDTRRyG 288  Pneumocystis cari...
ORY83695  209 TTVKSIGGah----vRYGLFADRpAPAGASVGHLtGIVELQSQYIAKEENLYqqLKGPRQHVVFVDq--tVLAIDARVsG 282  Protomyces lactuc...

Feature 1        #####       #                             #          #######                 
Q10362    289 SKARFARKGCqSNSVVSSVYmng-----------snSVPRFILYSTTHIApETEIIGDWTLDIShpfrqfapgmsrpsfn 357  Schizosaccharomyc...
EJD34677  218 GATRFVRHGCwPNAELLPARig------------pgGQLAFVLAATRDIEpGDEIVLPWEWDDMhpvhrfaranlltsnt 285  Auricularia delic...
CAF06059  363 SQARYIRRSCkPNAMLETYLsd-------------gYELHFWLVTDRQVAaREEITLPWDFRFPnenksrmlrvlglsde 429  Neurospora crassa
P36124    397 NSTRYLRRSCqPNVELVTIKlqdtdnrndkssgrksSRIKFVLRALRDISeDEELYIKWQWDSKhpilklikgmtidsld 476  Saccharomyces cer...
P42948    421 GLTRYIRRSCePNVELVTVRpldekp-----rgdndCRVKFVLRAIRDIRkGEEISVEWQWDLRnpiweiinaskdldsl 495  Saccharomyces cer...
EGX51648  347 SEARFVRRSCrPNLKFETMVid-------------gTDLKFALYTSQPIErGAELTIGWEWDNTlpfarllddaatveel 413  Arthrobotrys olig...
KTW28056  289 TDSRFIRRSCkPNAKLITVAss------------snFFIHIALYSLTEIQsGSEITIGWDWDVDhpayyienqecvpen- 355  Pneumocystis cari...
ORY83695  283 NVFRFCRKSCrPNCSIVPLAvaprs-------ksdlRVLRFTVVLSEALSvGSELTVGYGWPNPeieripgleedvaa-- 353  Protomyces lactuc...

Feature 1                                                
Q10362    358 m------------eelellsevlstflsfnECASQd-KKNCVF 387  Schizosaccharomyces pombe 972h-
EJD34677  286 sn-----------lrahvgsfltaaegfipPCACAd-PNTCLW 316  Auricularia delicata TFB-10046 SS5
CAF06059  430 dtsahaessvddgeyqaltswlhnilseygGCACNl-GSECAF 471  Neurospora crassa
P36124    477 d------------leryglinsvetilsngECGCGnnSKDCYL 507  Saccharomyces cerevisiae S288C
P42948    496 pd-----------pdkfwlmgsiktiltncDCACGylGHNCPI 527  Saccharomyces cerevisiae S288C
EGX51648  414 ep----------elvqrmktwadtvtatvgECACPd-SDVCLM 445  Arthrobotrys oligospora ATCC 24927
KTW28056  356 ---------------dvkygqeliyyinglECACEi-GKNCIL 382  Pneumocystis carinii B80
ORY83695  354 -----------------qtrfaqqvqdvlgECACGqgARECQV 379  Protomyces lactucaedebilis

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