Conserved Protein Domain Family
SET_SETD4
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cd19177: SET_SETD4 
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins
SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Links
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Statistics
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PSSM-Id: 380954
Aligned: 51 rows
Threshold Bit Score: 174.795
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative SAMcatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 binds H3K36M peptide and SAM.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ##                 #                                               
Q9NVD3     46 QDSNLAPACFPgTGRGLMSQt-sLQEGQMIISLPESCLLTTDTVIrsylgayit-------------------------- 98  human
KIM27463   20 EHNLAECREFPeTGRGLAVVr-dTKPNEILFTIPKTCLLNMDTLRdwarena---------------------------- 70  Serendipita vermif...
ODQ66998   16 VSSKIKVKKFLgKGHGVVAIe-dIKPGERLILVRNAQLINMRNVYpyflnffsgdstql--------------------- 73  Nadsonia fulvescen...
EOR04971   15 AVTALRPQFTShGGYSLLTSt-hVHPAEVFLFIPKQCLLNVESESirqryp----------------------------- 64  Wallemia ichthyoph...
ODV60627    4 LSPKVSVRYTKsFGHSVYSCg-pLSASESLVSVPSHYLLNVVSVLssihtykascsgsssctgpell------------- 69  Ascoidea rubescens...
NP_986559  21 ISDKIEIVQDAaSGRGVRLKqchINSNEEIIGIPSEFQLNFHSVLhhlsqfnrklvvpgvtvtepegda----------d 90  Ashbya gossypii AT...
ODQ45492   23 ISARIRVVDEIsLGRCITTDe-aVKKNELLLSVPNQFLLNYTTVLqhlsysnngidqflrkrilqfnnrvy-------at 94  Pichia membranifac...
EEU07799   20 IAPNISICESPeTGRGIVLShgsIRKNDIIVSVPSSKQLNFHTILchiskfnkelnipgitidrkpinyedniieaenka 99  Saccharomyces cere...
KNE97218   30 GEFKATIQASShSGRILVAKe-dIHEATPILSLPRSVLLDTQTIPsefiery---------------------------- 80  Puccinia striiform...
CDK24609   24 ISPRLKVKSDLvYGRSIWIDs-dAKEHEQLISIKFNYTLNVVTVCrqlknfeavdsvsdve------------------- 83  Kuraishia capsulat...

Feature 1                                                                                     
Q9NVD3     99 --------------kwkpppsplLALCTFLVSEKHa---------gHRSLWKPYLEILPKay----tcPVCLEPEVVNLL 151 human
KIM27463   71 ----------------iahlsatQMLAAFLATYKAggs-----sskHIQFYIPYLDSLPDnfd---fhPLSWTMDSPMKQ 126 Serendipita vermif...
ODQ66998   74 ----------sdgisilntisaqGIMALFLLMEQTs---------kSKSPWANFLSVLPTpedl-qttPLTWERCETQEP 133 Nadsonia fulvescen...
EOR04971   65 -----------------rsltsfQILSSHLTRLRMgd-------leCTRLESPYLDTLPAdfs---fhPLCWPQEKLDRL 117 Wallemia ichthyoph...
ODV60627   70 --lvhrcylavelgamltqlssfQMVAMFLLLESKr---------gSASFFHPFLTFLAAsfdachslPLTWLFNDSSDL 138 Ascoidea rubescens...
NP_986559  91 aedprtraygvldantvlqlssfQLLALYILAEWVllkt---wgceTQSFWQPFFEIFPTsadl-raiPAYYSLQFASTS 166 Ashbya gossypii AT...
ODQ45492   95 nadeitflyskldcekllsltshQLLTLFICLERKr---------hESSFWYPLFSCFPElney-kaiPMTWNLKIASEH 164 Pichia membranifac...
EEU07799  100 wadpryglyselskefllslssfQLVSFYILVENFllpkw--thneIYSDWKPFFDVWPSmeel-rsiPAIWNCDPNSRY 176 Saccharomyces cere...
KNE97218   81 ----------------gqglnsiQTLTLYLTIYSGqkrlknsstidYYLPFESYLNTLPQdvldfqgvPLIWQLNITYKK 144 Puccinia striiform...
CDK24609   84 -------nfyanlknvcetlnsfQLIPLFLVCESRr---------gPKSFWSPFVKCLPRieel-sgmPMTWLWRNQESR 146 Kuraishia capsulat...

Feature 1                                                                                     
Q9NVD3    152 pks----------------------------------------------lkAKAEEQRAHVQEFFASSRDFFSSLqplfa 185 human
KIM27463  127 mhdtl-----------------------------------------ptrvlKKLTGVEKRFLSDHSIIQSILPGIs---- 161 Serendipita vermif...
ODQ66998  134 snssqanfkarknnsnggsnsdgdsnsdsdseveatilhdaqwrllsystrQYVLKQEKNVTGDFKGCESLIKLLnslap 213 Nadsonia fulvescen...
EOR04971  118 pih----------------------------------------------vrKLVEHVSHRFESDFAAFRSHFEASklliq 151 Wallemia ichthyoph...
ODV60627  139 illlp------------------------------------------hsmrAHQQKIYTRFTADYNAVLSFLTSLsvdya 176 Ascoidea rubescens...
NP_986559 167 kellpl---------------------------------------lppasaCHCRRICELVQGDWARIRGILEQWnilfa 207 Ashbya gossypii AT...
ODQ45492  165 hvklfgl--------------------------------------lprsvlNHAKSQSNQFYSDIETIGSVLKEQdvi-- 204 Pichia membranifac...
EEU07799  177 hsliey---------------------------------------lpaasrKHMARISGLVREDWETISEVVLKWneiyg 217 Saccharomyces cere...
KNE97218  145 qlnqiklneihtlnknrsdnqd--------dqypvkngqfkcyelmtwttiKQADEVLDRFVKDWTILNHTKPSHpsfh- 215 Puccinia striiform...
CDK24609  147 swtll-----------------------------------------pkwsrERSQEQLERFKSDWKIVSKVLSDCsysd- 184 Kuraishia capsulat...

Feature 1                               ######                             #####              
Q9NVD3    186 ea--------vdsifsYSALLWAWCTVNTRAVylrprqre------clsaepdTCALAPYLDLLNHSPh-------VQVK 244 human
KIM27463  162 ----------------KSNFLWGWLNVNTRSLyhkcrd---------arsqedHITMCPLLDFANHSIs------aPNFN 210 Serendipita vermif...
ODQ66998  214 tt-------tdlsmitSAQYKHAWLCVNSRCLyhtlsaasslktrafnwkasdNLTMAPYVDFLNHSTd-------TKLH 279 Nadsonia fulvescen...
EOR04971  152 k----------htqpiAEVFKWAWLVVNTRCLyypiqd----------vekdsQLSLCPYLDLLNHSSp------sPNTT 205 Wallemia ichthyoph...
ODV60627  177 -----------vlvadKLEFLKFWLAINTRCLyn------------------hNFTLCPLIDFLNHTAdqdssvqlLNTI 227 Ascoidea rubescens...
NP_986559 208 dre------titleqqFEHFLHIYFVINSRCLytpvpl---------kdnrddNFTMVPYVDFLNHITtvs---ehCYPK 269 Ashbya gossypii AT...
ODQ45492  205 --------------ltESEYLWAWLAINTRCLyyklpkylpi--tekteseasNITLVPFVDFINHRCd------eSNCL 262 Pichia membranifac...
EEU07799  218 slsctknsdkftsdelFSLFVHVYFIINSRCLyakiplk--------iedspsNFTLVPYVDFMNHICes-----dLHCY 284 Saccharomyces cere...
KNE97218  216 -------------dcrLSDLAWAWLIVNTRCVsfdiga----------kdhdnNITLAPGFDMANHCSs-------SKVT 265 Puccinia striiform...
CDK24609  185 -------------lirEKEFLWAWLCCNTRCLymelpas-------lalstadNISMVPYLDFINHDYse----aaVEPI 240 Kuraishia capsulat...

Feature 1     #                                             ####               
Q9NVD3    245 AAFNEeth----------syEIRTTSRWRk-----------HEEVFICYGPHDNQRLFLEYGFVS 288 human
KIM27463  211 TPLHRrkgh--------pipSMIAPPDRGlk---------aGDQIFLLYGHHSNETMFTEYGFTD 258 Serendipita vermifera MAFF 305830
ODQ66998  280 CVAKTvtlg--------fevCASPVSGYKk-----------GEEILLCYGAHSNEKLLCEYGFCV 325 Nadsonia fulvescens var. elongata...
EOR04971  206 NLFNAlp-----------kpEIPLREGGYelvnnsthtippDTEICFMYGPHSDDFLLAEYGFVL 259 Wallemia ichthyophaga EXF-994
ODV60627  228 NFTKNdthf-------dfslRITSNSTNPtp--------apNLQIYLNYGPHSNEFLINEYGFKL 277 Ascoidea rubescens DSM 1968
NP_986559 270 VESVRrlygg------vgrfSIKCGPHAYrv---------pMEEVFLNYGAHSNDFLLNEYGFTV 319 Ashbya gossypii ATCC 10895
ODQ45492  263 ARVSKsg------------yEVLATGNISi-----------GTHLWFTYGPHNDEFLQSEYGFST 304 Pichia membranifaciens NRRL Y-2026
EEU07799  285 PQLSPqlrsegeniigigqfTIRCGDHLYdn---------iNEELFLNYGAHSNDFLLNEYGFVV 340 Saccharomyces cerevisiae JAY291
KNE97218  266 TIVNRkg------------iTMYSSDPTEttnhsk-piikkGEEIKFKYGPHSNSTLLTEYGFVD 317 Puccinia striiformis f. sp. triti...
CDK24609  241 APPNIdq-----------dwRLLSGKKTK------------QGEVCFSYHCDSDEYFLCEYGFML 282 Kuraishia capsulata CBS 1993

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