4YNM,4YPU,4YPE,3OPE,4YPA,4YNP


Conserved Protein Domain Family
SET_ASH1L
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cd19174: SET_ASH1L 
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).
Links
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Statistics
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PSSM-Id: 380951
Aligned: 26 rows
Threshold Bit Score: 252.984
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ###                #         #   #       #######                ##### 
4YNM_A         79 CLERFRAEe-KGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYhnHSDHYCLNLDsGMVIDSyRMGNEARFINHS 157  human
XP_002121834 2121 DLERFRTNd-RGWGVRTNSDIPEGQFLLEYVGEVVSEREFRRRTIENYnaHNDHYCVQLEaGTVIDGyRLANEGRFVNHS 2199 Ciona intesti...
ESN90512       73 HLKKFPTQe-CGLGVKATKPLKAGQFIIEYVGEVMSELEFRRRMSTLYshMQHHYCLSLEgGVVIDGyKSGNISRLINHS 151  Helobdella ro...
OWF39033     1743 SLKKITTEd-RGCGVKSLEPIHTGQFILEYLGEVVSEQEFRRRMTENYsqERHHYCLNLDsGALIDGyRMGNIGRFVNHS 1821 Yesso scallop
KJE89830      551 NLKVFQTPn-AGYGLRCTDPIAPGQFVMEYVGEVVSDAERERRMWGPYagNPNHYFLELEkGVLIDAcSKGCDARFINHS 629  Capsaspora ow...
EFX90460      171 GLERFMTKe-KGWGVRCRNELKTGVFILEYVGEVVSDKEFKERMHTVYvhDTHHYCLHLDgGLVIDGhRMGGDGRFVNHS 249  common water ...
KHN77835      776 KLSLFETNngRGFGVRTDVPIQKGQFVCEYVGEVVSTETFDARNERSYraYRNHYALNLCpGFVIDAyRKGNMARFVNHS 855  dog roundworm
Q9VW15       1391 GVERFMTAd-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYlnDTHHYCLHLDgGLVIDGqRMGSDCRFVNHS 1469 fruit fly
XP_013389869 1958 CLEKYQTGd-RGYGVRTKAHIKTGSFILEYVGEVVSEHEFRRRMMETYshDFHHYCLNLDsGTVIDGyRMGNIGRFVNHS 2036 Lingula anatina
XP_004995076  383 AIKRAPTPg-KGYGVFATAYIPKGTFVIEYTGEIMTSSAFTQRANTLYraRKHFHCLNLDrGLVIDAgQAGSEARFINHS 461  Salpingoeca r...

Feature 1              ###              #          #########    #####        #  
4YNM_A        158 CDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNveKQQLCKCGFEKCRGIIGG 219  human
XP_002121834 2200 CQPNCEMQKWVVNGEYRVGLFAKRPIVSSEELTYDYNFHAYNldRQQPCRCGSSECRGVIGG 2261 Ciona intestinalis
ESN90512      152 CSPNCQMQKWNVNGVYRIGLFALKDVEPNEELTYDYNFHAYNvnTQQACKCGSSNCRLVVGG 213  Helobdella robusta
OWF39033     1822 CEPNCEMQKWNVNGYYRMALFALKDIQAGRELSYDYNFHSFNmdSQQICKCGSEKCRGVIGG 1883 Yesso scallop
KJE89830      630 CDPNCHVEKWNVNGEFRVGIFASRAIAPNEELSYDYRFETLGe-IQQQCWCGAANCRKVIGK 690  Capsaspora owczarzaki ATCC 30864
EFX90460      250 CAPNCEMQKWSVNGLPRMALFALRDISPLEELSYDYNFSLFNpaEGQPCKCGSPQCRGVIGG 311  common water flea
KHN77835      856 CAPNCEMQRWSVNGQHRIGLFALRSIDKGEELTYDYNWDSFDfyGVTPCSCGVPSCRGFLNK 917  dog roundworm
Q9VW15       1470 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNpsEGQPCRCNTPQCRGVIGG 1531 fruit fly
XP_013389869 2037 CQPNCEMQKWNVNGVYRIGLFALKDIPADTELTYDYNFHAFNmdSQQICKCGSTKCRGIMGG 2098 Lingula anatina
XP_004995076  462 CDPNCHIEKWNVNGHWRAGVFASRDIKGDEELSYDYNFHNFN--EKLVCRCGAANCRGEIRP 521  Salpingoeca rosetta

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