4AUB,3N6Q


Conserved Protein Domain Family
AKR_AKR14A1
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cd19150: AKR_AKR14A1 
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Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Links
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Statistics
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PSSM-Id: 381376
Aligned: 12 rows
Threshold Bit Score: 575.557
Created: 14-May-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4AUB: Escherichia coli aldo-keto reductase AKR14A1 in complex with cofactor NADP and citrate, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ### #                         #   ##                           
4AUB_A     34 QYRYCGKSGLRLPALSLGLWHNFGhvnaLESQRAILRKAFDLGITHFDLANNYGpppGSAEENFGRLLREdfaayRDELI 113 Escherichia coli K-12
3N6Q_A     14 QYRYCGKSGLRLPALSLGLWHNFGhvnaLESQRAILRKAFDLGITHFDLANNYGpppGSAEENFGRLLREdfaayRDELI 93  Escherichia coli K-12
Q46851     14 QYRYCGKSGLRLPALSLGLWHNFGhvnaLESQRAILRKAFDLGITHFDLANNYGpppGSAEENFGRLLREdfaayRDELI 93  Escherichia coli K-12
CAR50823   14 QYRTCGKSGLKLPALSLGLWHNFGdstpISTQREILRTAFDLGINHFDLANNYGppyGSAETNFGRLLKEdfrpyRDELL 93  Burkholderia cenoc...
AEV30996   13 KYNYCGKSGLKLPAVSLGLWHNFGdatpLANAREMIHTAFDLGITHFDLANNYGppaGSAELNFGKIFSQdlaayRDQLI 92  Sphaerochaeta pleo...
CNG28316   16 PYRRCGRSGLRLPAISLGLWHNFGddrpVDVQRAILRRAFDLGVTHFDLANNYGppyGSAETNFGRIMREdlapyRDELI 95  Mycobacterium tube...
OLC73889   14 PFRRTGRSGLKLPAISLGLWQNFGgdrpIETQRAIIRRAFDLGITHFDLANNYGppyGSAEENFGRILKSdlagrRDELI 93  Deltaproteobacteri...
PLP56460   14 TYNRCGHSGLKLPAISLGLWHNFGedtpHRVKRAICQKAFDLGITHFDLANNYGpppGSAEVAFGEILRSdfagyRDQMI 93  Mesorhizobium loti
SJM35482   14 VYNRCGRSGLKLPAISLGLWHNFGddtpHRTKQAIARKAFDLGITHFDLANNYGpppGSAETAFGEILRTdfssyRDELI 93  human
AJZ91190   14 QYRACGQSGLQLPALSLGLWHSFGgvspLESQRDLLRTAFDLGITHFDLANNYGpppGSAEENFGRLLKQdfsgyRDELI 93  Beauveria bassiana...
PTX50449   14 IYRRCGHSGLKLPAVSLGLWHNFGhdtpHQVKRDICRTAFDLGITHFDLANNYGpppGSAEEAFGEILRTdfagyRDELI 93  Nephila clavipes
OGV69822   14 PYRRCGRSGLMLPRLSLGLWHNFGdvdcYATARDVVLGALDRGITHFDLANNYGpppGSAEKNFGRILREdlqpyRDEII 93  Lentisphaerae bact...

Feature 1           #                                      #                             #    
4AUB_A    114 ISTKAGYDMWPGPyg-sgGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDEnTPMEETASALAHAVQSGKALYVGISSYsP 192 Escherichia coli K-12
3N6Q_A     94 ISTKAGYDMWPGPyg-sgGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDEnTPMEETASALAHAVQSGKALYVGISSYsP 172 Escherichia coli K-12
Q46851     94 ISTKAGYDMWPGPyg-sgGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDEnTPMEETASALAHAVQSGKALYVGISSYsP 172 Escherichia coli K-12
CAR50823   94 ISTKAGWDMWPGPygsggGSRKYVLASLDQSLQRMGLDYVDIFYSHRFDAhTPLEETAGALASAVQQGKALYIGISSYsA 173 Burkholderia cenoc...
AEV30996   93 ISTKAGYNMWPGPyg-ewGSRKYLLSSLDQSLQRMGLDYVDIFYSHRFDPdTPLEETMGALETAYRQGKCLYVGISSYsA 171 Sphaerochaeta pleo...
CNG28316   96 ISTKAGYDMWPGPyg-ewGSRKYLLASLDQSLRRMGLDYVDIFYSHRFDPeTPLEETMGALDRAVRSGKALYAGISSYsP 174 Mycobacterium tube...
OLC73889   94 ISTKAGYDMWPGPyg-iwGSRKYLLASLDQSLKRMGLEYVDIFYSHRFDPeTPLEETMGALDTAVRQGKALYVGISSYsA 172 Deltaproteobacteri...
PLP56460   94 ISTKAGYDMWPGPyg-ewGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPdTPLEETMGALDHAVRSGKALYAGISSYnS 172 Mesorhizobium loti
SJM35482   94 ISTKAGYEMWAGPyg-ewGGRKYVLASLDQSLKRMGLDYVDIFYSHRFDPdTPLEETMGALDHAVRSGKALYAGISSYnS 172 human
AJZ91190   94 IATKAGYDMWPGPyg-sgGSRKYLLASLDQSLRRMGLEYVDIFYSHRVDEkTPMEETASALAHAVQSGKALYVGISSYsS 172 Beauveria bassiana...
PTX50449   94 ISSKAGYDMWAGPyg-ewGSRKYLIASCDQSLKRMGLDYVDIFYSHRFDPeTPLEETMMALDHIVRSGRALYVGISSYnS 172 Nephila clavipes
OGV69822   94 VSTKAGFRMWPGPyg-ewGSRKNLLASLDQSLTRMGLEYVDIFYSHRFDPdTPLEETMHALDQAVRSGKALYAGISSYrP 172 Lentisphaerae bact...

Feature 1                         #                            ######   # #                   
4AUB_A    193 ERTQKMVELLREwkiPLLIHQPSYNLLNRWVdksgLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGipqdsrmhregnkvr 272 Escherichia coli K-12
3N6Q_A    173 ERTQKMVELLREwkiPLLIHQPSYNLLNRWVdksgLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGipqdsrmhregnkvr 252 Escherichia coli K-12
Q46851    173 ERTQKMVELLREwkiPLLIHQPSYNLLNRWVdksgLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGipqdsrmhregnkvr 252 Escherichia coli K-12
CAR50823  174 AKTREMAALLAQykvPLLIHQPSYNMLNRWIee-dLLGTLDDVGAGSIAFTPLAQGLLTSKYLNGvpadarvnkpg--gg 250 Burkholderia cenoc...
AEV30996  172 KKTREAYAILKErniPILIHQPSYSMLNRWVee-eLLDTIGELGMGTICFSPLAQGMLTDKYLEAipensraake---gt 247 Sphaerochaeta pleo...
CNG28316  175 ERTAEAAAILREmgtPLLIHQPSYSMLNRWIeg-gLLDTLGREGVGCIAFSPLAQGMLTDKYLDGipegsraskg----t 249 Mycobacterium tube...
OLC73889  173 RRTKEAAAILRDlgtPLLIHQPSYSMLNRWIep-dLLEVLGEEGIGCIVFSPLAQGLLTDRYLAGvpagsrasrs----g 247 Deltaproteobacteri...
PLP56460  173 QRTREAADILKRlgtPCIIHQPSYSMLNRWVeddgLLDTLEGLGVGSIVFSPLAQGMLTDKYLGGvpegsratqg----k 248 Mesorhizobium loti
SJM35482  173 QRTREAADILKQlgtPCIIHQPSYSMLNRWVeddgLLDTLEGLGVGSIVFTPLAQGMLTDKYLGGipegsrasqg----k 248 human
AJZ91190  173 ERTQKMADLLREwkiPLLIHQPSYNLLNRWVdksgLLDTLQQNGSGCIAFTPLAQGLLTGKYLNGipegsrmqvegnkir 252 Beauveria bassiana...
PTX50449  173 QRTREAVAILKDlgtPLLIHQPSYNLLNRWVerdgLKDTLADLGVGSIAFTPLAQGILTKKYLGGipagsraaqg----k 248 Nephila clavipes
OGV69822  173 EPTRQAAAILAKlgtPCLIHQPSYNMFGRWIee-gLTDALAELGIGCIVFSPLAQGQLTSRYLNGipadsragka----h 247 Lentisphaerae bact...

Feature 1                                  #                #####   #  ##               
4AUB_A    273 gltpkmltEANLNSLRLLNEMAQQRGQsMAQMALSWLLKddRVTSVLIGASRAEQLEENVQAlnnLTFSTKELA 346 Escherichia coli K-12
3N6Q_A    253 gltpkmltEANLNSLRLLNEMAQQRGQsMAQMALSWLLKddRVTSVLIGASRAEQLEENVQAlnnLTFSTKELA 326 Escherichia coli K-12
Q46851    253 gltpkmltEANLNSLRLLNEMAQQRGQsMAQMALSWLLKddRVTSVLIGASRAEQLEENVQAlnnLTFSTKELA 326 Escherichia coli K-12
CAR50823  251 slkqehlsADNLEHVRKLNTIAERRGQsLAQMALAWVLRngRVTSALIGASRAEQVRENVGAlqnLEFSAEELA 324 Burkholderia cenocepacia...
AEV30996  248 alsakmltKDNLDRIRNLNEIAKKRGQsLAQMALAWVLRrkEITTVLIGASSPAQIQENVGAldnLTFTDDELK 321 Sphaerochaeta pleomorpha
CNG28316  250 sfssslltEENLRHVRTLNEVARGRGQsLAQMALAWSLRdgRVTSALIGASSVRQLEENLAAldrLDFTADELA 323 Mycobacterium tuberculosis
OLC73889  248 sfsadlmtEQVLSKVRALQQIATRRRQtLAQMALAWTLRdpRITSTLVGASSVAQLEQNFGVldkLDFSADELS 321 Deltaproteobacteria bact...
PLP56460  249 slrqsflnEQTLANIQALNGIAKKRGQtLAQMALAWVLRggRVTSALIGASRPEQVEDCVGAlknLDFSEAELA 322 Mesorhizobium loti
SJM35482  249 slrpafinDKTIANIKALNAIASRRGQtLAQMALAWVLRkgRVTSALIGASRPEQVEDCVGAlkaLDFSDAELA 322 human
AJZ91190  253 glnekmltEANLSSLRLLNEMAQQRGQtMAQMALSWLLKdqRVTSVLIGASRPEQLQENVKAldnMNFTAEELE 326 Beauveria bassiana D1-5
PTX50449  249 slapetitPRALDSVRALDALAQKRGQtLAQMAIAWVLRdgGITTALIGASKPEQVVDCAGAignLTFTPEELA 322 Nephila clavipes
OGV69822  248 gflkadqvQSNLPKIRALNAIAQKRGQsLAQMAIAWDLRlpVVTTALIGASSVAQLDENLKAleqLEFSEAELA 321 Lentisphaerae bacterium ...

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