Conserved Protein Domain Family
AKR_AKR11B2

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cd19149: AKR_AKR11B2 
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins
Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Statistics
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PSSM-Id: 381375
Aligned: 20 rows
Threshold Bit Score: 462.512
Created: 12-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Bacillus subtilis AKR11B (1PZ1) binds cofactor NADP.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     ###                                #    #                       
P77256      3 KIPLGTTDITLSRMGLGTWAIGGgpawngdLDRQICIDTILEAHRCGINLIDTAPGYNFGNSEVIVGQALKKlpREQVVV 82  Escherichia coli s...
PKF79029    3 YRKIGRSDISASAVVLGTWGIGGgsiwgkeADEKELINTIHAALSSGINFIDTAPGYGFGESERIIGKAIRKr-RDEVVV 81  Vibrio sp. vnigr-6D03
EAQ81844    3 KRALGRSGIEASVIAFGAWAIGGwtw--ggADENESIRAIHAFLDAGGDLIDTAPIYGFGASEEVVGKAIADr-RDKVVL 79  Blastopirellula ma...
ACY16792    3 TRPLGPSGIEASVIALGAWAIGGwmw--ggADENDAIRTIHAAIDAGVNFIDTAAVYGFGASEELVGKAIAEr-RGEVVL 79  Haliangium ochraceum
OGV62265    3 YRALGSSGIQASVVGLGTWAIGGwmw--ggTDEPAAIRAIQAALDDGINLVDTAPAYGFGLSEQLVGKAIRGr-RDRVVL 79  Lentisphaerae bact...
OQW95064    3 YRQIGTTDMKASCVAFGAWAIGGgpw-wgpTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDr-RDKVLI 80  Verrucomicrobia ba...
OQY28373    3 LRRLGKSTLKVSPLIFGAWAIGGwyw--ggTDDNKAVAAIQQSIDLGINMIDTAPMYGYGHSEKVVGRAIKGr-RNKVLI 79  Candidatus Cloacim...
PLP57645    7 QRAIGASGIQASAVGLGTWAIGGwmw--ggTDEQASIRAIEASIDAGVSLIDTAPAYGLGRSEEIVGKAIKGk-RDKVVI 83  Mesorhizobium loti
SJM29803    7 TRSIGKSGVVASAVGLGTWAIGGwmw--ggTDEAESIAAIQASIDAGVSLIDTAPAYGLGRSEEIVGKAIKGr-RDRAVI 83  human
KWT91810    3 TRQFGNTALYITPITFGAWEIGGepf-ysnLPDDDSIALIHEAFVLGINFFDTAPIYGFGHSERILGKAVKKf-RDKIVI 80  Nitrospirae bacter...
Feature 1       #                                                                             
P77256     83 ETKCGIVWerkgslfnkvg-------------------drqlyknlspESIREEVAASLQRLgIDYIDIYMTHWQSvppf 143 Escherichia coli s...
PKF79029   82 ATKCGLVWdwegtehfstd-------------------gktlrrnlspESIRREVEESLKRLnTDYLDLYQVHWPSnapy 142 Vibrio sp. vnigr-6D03
EAQ81844   80 ATKCSMRWdlsdqqkerakkkfsttqqnvdwtgekqeqsfdvfiysgrDGIREEVERSLKRLqTDVIDLYQTHWQDda-- 157 Blastopirellula ma...
ACY16792   80 ATKCGMVWntdkgkhafds------------------egksiyrylaaSSIREEVELSLRRLgVETIDLYQTHWQDpt-- 139 Haliangium ochraceum
OGV62265   80 ATKCGLVWhvqqgdhyfnsdekap---------nqsatqyrvykclrpETIRYEIEQSLKRLgVDCIDLYQTHWQEst-- 148 Lentisphaerae bact...
OQW95064   81 ATKCGLWHrdargsewftm------------------gshtirrslrpDTIRIEVEESLRRLgVDRIDLYQTHWQAiepe 142 Verrucomicrobia ba...
OQY28373   80 ATKCGLRWdreegqyffqpee---------------nnnlkvyknlrkESIIEECERSLKRLdIDVIDLYQCHWMDkt-- 142 Candidatus Cloacim...
PLP57645   84 ATKCGLNWhsgkgnhffdq------------------dgkpvhrylgaDGIAYELDQSLRRLgTDHIDLYITHWQDpt-- 143 Mesorhizobium loti
SJM29803   84 ATKCGLNWhskkgnhffdq------------------dgtpvnrylgaEGIAYEVEQSLRRLgTDYIDLYITHWQDpt-- 143 human
KWT91810   81 STKCGLRWkenllsg--------------------------iykdsskKSILDEIDETRKRLdTDVIDLYLVHWPDvn-- 132 Nitrospirae bacter...
Feature 1                              ##                  #                            ######
P77256    144 ftPIAETVAVLNELKSEGKIRAIGAANVdADHIREYLQygeLDIIQAKYSILDRamENELLPLCRDNg-IVVQVYSPLEQ 222 Escherichia coli s...
PKF79029  143 htPIEETLECLVGLKQEGKIRAIGVSNLsEEETLAYCKgnqIDTNQIRYSMLWEk-DARATVNQNQSlgMSTMAYQAMEQ 221 Vibrio sp. vnigr-6D03
EAQ81844  158 -tPIEERMGALEELKQEGKIRAIGVSNAsREQIDQYRQfgqVDTDQEKYSMLDRgmETANLPKCADEq-IAFLAYSPLGQ 235 Blastopirellula ma...
ACY16792  140 -tPIAETMETLLALKQAGKIRAIGVSNAsVEQMNEYMSagqLDADQESYSMLDRklDAEQLPYCAKHg-IAVLAYSPMAR 217 Haliangium ochraceum
OGV62265  149 -tPIADTMATLQDLKRQGKIRAIGASNAsVEQLDAYRRagtLDVDQEKYSMLDRahEADLLPACVRHr-LAFLAYSPLAS 226 Lentisphaerae bact...
OQW95064  143 ktPIADTMACLMDLRAQGKIRAIGVSNAtTADMDAYRAageLSACQPRYSMLDRaiEADVLPYCLRSn-VAILAYSPLEQ 221 Verrucomicrobia ba...
OQY28373  143 -tQIEETMEALLRLKEQGKIRTIGVSNFnVEAMIKAGRlaeIASDQPKYNLLDRriEKNVLPYCRKNk-IGVIAYSPLQQ 220 Candidatus Cloacim...
PLP57645  144 -tPIAETVAALEKLKAAGKIRAIGASNVnPEELNQYVAagqLDAIQERYSMIDReiEGTLLPITQRNd-VATLSYSSLAL 221 Mesorhizobium loti
SJM29803  144 -tPIAETMQALERLKSAGKIRAIGASNLnPAELQHYVTagqLDAIQEKYSMLDReiEQTLLPIARQHq-VAALSYSSLAL 221 human
KWT91810  133 -tPIGQTIETLETIKAQGKIRYYGLSNFsTAQIAEAARygsVSALQSQYSMLNLklENSELPYCIENn-IGFQAYSPLHR 210 Nitrospirae bacter...
Feature 1     #  # #            #                                   #                ### #   #
P77256    223 GLLTGTItr--dYVPGGARANkv---wFQRENMLKVIDMLEQWQPLCARYQCtIPTLALAWILKQsdlISILSGATAPEQ 297 Escherichia coli s...
PKF79029  222 GLLSGKVtmdtqFDANDIRNVdawnpwFVKEKRAQVLQQMEAWKPLLDKYSCtMAQLIVAATSQVsgiDFVLCGARSVGH 301 Vibrio sp. vnigr-6D03
EAQ81844  236 GLLTGKItpereYDEGDQRRFkd---rFKPENVRKVQAMLEPMLPIAERHQVsLAQLTMAWTLAQpgcSHVLCGARNPQQ 312 Blastopirellula ma...
ACY16792  218 GLLTGKVtpersFPEGDHRAThp---lFSVDNRKQVQALLERCQPVAERHGItLAQLSVAWALHQggmTHALVGARTPEQ 294 Haliangium ochraceum
OGV62265  227 GLLTGRIgpdriFNAGDLRRGnp---rFSRDNLERVSRLLQAFQPIADAHHVsLGQLVIAWTVAQpgcTHALVGARDPAQ 303 Lentisphaerae bact...
OQW95064  222 GLLTGKIgmdrtFGADESRNRip---wFLPANRARVLAMLGGWKDLCAAHACtLGQLVIAWTVAQpglTIALCGARKVAQ 298 Verrucomicrobia ba...
OQY28373  221 GLLTGKVtpdreFPKGDWRSKlp---lFKKANREKILTTLEKMRPIADQYQAtFAQIALNWLFHEpgiVSAIVGIRTREQ 297 Candidatus Cloacim...
PLP57645  222 GLLTGSIepgraFSGDDQRKDnp---rFSASNRQKVATLKQAIQPISDQHKAsMAQIVIAWTLAQpgiTFALCGARNPEQ 298 Mesorhizobium loti
SJM29803  222 GLLSGAIdpareFSGDDQRKDnp---rFSQASRRKVAALKHALTPVAEVHQAsMAQIVIAWTLAQpgiTFALCGARNATQ 298 human
KWT91810  211 GVLTDKTveslrEFAQPAINWi----lDSMTAENTRQVLDIKEIMNYGGYGCsFASFVTAWTIAQpgiTTAIIGTTKPQH 286 Nitrospirae bacter...
Feature 1                           
P77256    298 VRENVAalnINLSDADATLMRE 319 Escherichia coli str. K12 substr. DH10B
PKF79029  302 AEQNAKagsLNIDKEDANTMLS 323 Vibrio sp. vnigr-6D03
EAQ81844  313 AIDNAGagdVELTSEEIAEISS 334 Blastopirellula marina
ACY16792  295 AIENAKagtVELNEDDLATMAD 316 Haliangium ochraceum
OGV62265  304 AHENARagdIRLEASELATMRQ 325 Lentisphaerae bacterium RIFOXYC12_FULL_60_16
OQW95064  299 VLENAKaggLALDTATLARMRA 320 Verrucomicrobia bacterium A1
OQY28373  298 AVENAKsvdFILSDEERRQIRS 319 Candidatus Cloacimonetes bacterium 4572_55
PLP57645  299 ALDNARageVRLSSEERTSIDK 320 Mesorhizobium loti
SJM29803  299 ALDNARageISLSAAELTAVDA 320 human
KWT91810  287 IKDVAGaaeITISAEDARTIRS 308 Nitrospirae bacterium HCH-1

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