Conserved Protein Domain Family
AKR_BaDH-like

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cd19129: AKR_BaDH-like 
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins
Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Statistics
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PSSM-Id: 381355
Aligned: 9 rows
Threshold Bit Score: 557.456
Created: 20-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###                      #   ##                            #         
NP_772896  15 HESVTIPAVGFGTLIPDplvTRQAIRAALEAGFRHLDCAERYRNEAAVGDAMQDaFKAGKLRREELFVTTKLWNtNHRPE 94  Bradyrhizobium jap...
OYQ25369   19 HGSVEMPAVGFGTLFRDlsvTTQAVKDALEAGFRHFDCAERYRNEEQVGVAFKEmLDAGNVRREDLFITTKLWNtNHRPE 98  Pseudomonas mandelii
SIO71754   16 HGGGRMPALGFGTLIPDaatTQSATRDALEAGYRHFDCAERYRNEREVGEALRIgLAAGGIAREDIFVTTKLWNsNHRPE 95  Burkholderia sp. G...
SPE60422   16 NGSGAIPALGFGTLIPDpiaTKNATKAALEAGFRGLDTAERYRTEKEVGEAMKEvFKAGKIRREDVFVATKLWNtNHRPE 95  Verrucomicrobia ba...
SPF36080   15 DNGSLIPALGFGTLIHDltdTENTVLTAVEVGFRQFDCAERYRNENAIGEAIRRiLTEGKVRREDLFIAAKLWNtNHRPE 94  Syntrophobacter sp...
AGA28914   16 NGSGAIPALGFGTLIPDpmaTRTATKAALEAGFRQLDAAERYRNEKEVGEAMQEvFKAGKMKREEVFVATKLWNnNHRPE 95  Singulisphaera aci...
OMC21462   17 NNGEEIPALGFGTSLSDnsrTREAVKAAVEVGFRHLDAAERYRNEAEVGAALKElFASGMVRREELFVTTKLWNnNHRPE 96  Mycobacterium colo...
BAY21124   16 NGTGAIPALGFGTLIPDpiaTKNATKCALEAGFRQIDTAERYRTEQEVGEAMQEvFKAGKIKREDVFIATKLWNnHHRPE 95  Calothrix sp. NIES...
OQP44846    5 SNLINMPALGFGTLIPDavdTKNAVRYALEAGFRHFDCAERYRNEAVVGEAIQAgLAAGVISREDIFVTTKLWNtNHRPE 84  Niastella yeongjue...
Feature 1                            ##                                                ##     
NP_772896  95 RVKPAFDASRRRLqLDEIDCYIIHTPFAFQPGDEQDPRDASGrVIYDSGVTLVETWHALERLVDEGHCKSIGLSDItLEK 174 Bradyrhizobium jap...
OYQ25369   99 RVEPAFEASCRRLqVDYIDCYLIHTPFAFQPGDNQDPRDESGhVIYDDGVTLIETWRAMERLVDEGRCKAIGLSDItLEK 178 Pseudomonas mandelii
SIO71754   96 RVEPAFEASLERLgIDYLDLYLIHTPFAFQPGDEQDPRDENGdVIYDKGVTLLDTWRAMEDLVDHGRCRAIGLSDIgLNE 175 Burkholderia sp. G...
SPE60422   96 RVKPAFEASLKKLqLDYIDLYLIHTPFAFQPGEEQDPRDANGnVIYDTGVKLLDTWGALEELVDEGKCKAIGLSDVgLER 175 Verrucomicrobia ba...
SPF36080   95 RVKPAFEASLGRLqLGYLDLYLIHTPFAFKPGDNQDPRDERGnVIYDEGVTLLDTWHAMESLVDAGRCKAIGLSDVsLAV 174 Syntrophobacter sp...
AGA28914   96 RVKPAFEASLKKLqLDYVDLYLIHTPFAFQPGDEQDPRDANGnVIYDKGVTLLDTWRALEGLVDEGRCKAIGLSDVsLAQ 175 Singulisphaera aci...
OMC21462   97 RVKPALRASLGRLgLDTVDLYLVHTPFAFKPGDDQDPRDIHGaVIYDDGVTLSETWEAMEDLVGEGLTRAIGLSDIdVEG 176 Mycobacterium colo...
BAY21124   96 RVAPAFEASLKKLqLDYVDLYLIHTPFAFQPGDEQDPRDANGnVIYDEGVTLLDTWRRLESLVDEGKCKAIGLSNVsLEK 175 Calothrix sp. NIES...
OQP44846   85 RVEPAFEGSLKRLqLNYLDLYLIHTPFAFQPGDEQDPRDQSGnVIYDNSISLTDTWKAMERLVDGGKCRAIGLADVnLEK 164 Niastella yeongjue...
Feature 1                    #                         #######          #           #         
NP_772896 175 LREIVAvARIRPAMVQVESHPYlPEWDLLDFCREHGIVLQAFAALGHAmEPRVLEDPVITAIARRVQKTPAQVCLAWAVQ 254 Bradyrhizobium jap...
OYQ25369  179 LQEIVEvARIKPAVVQVESHPYlPEWELLEFCKQHGIIVLAFAPLGHGmEPNVLQDPVITQIAQRVQKTPAQVALAWSVQ 258 Pseudomonas mandelii
SIO71754  176 LRPLYEsARIKPAAVQVEAHPYlPETELLEFCKEKEIVFLAFAPLGHGiRPGPLEDPVISEIAARIGKTPAQVLLAWAIQ 255 Burkholderia sp. G...
SPE60422  176 VKEIFEaATIKPVVVHVESHPYlPEWELLDYCRKNGIVLQAFAALGHSsEPNVLADPVITAIANRVGKTPAQVVLAWAIQ 255 Verrucomicrobia ba...
SPF36080  175 LQEVADaARIKPAVLQVESHPYlQQSDLLDYCKSHGIVLQAFAPLGHNmTPKLIDDPVITTIARRVNKTPSQVLLAWAVQ 254 Syntrophobacter sp...
AGA28914  176 VKEIFEaGRIKPAVVHVESHPYlPQWDLLDYCRNNGIVLQAFAALGHSsEPKLLEDPVITAIAKRVNKTPAQVLLAWAIQ 255 Singulisphaera aci...
OMC21462  177 VRRIADtARIKPAVVQVESHPYhPQWELHGLRETDGIILLAFASLGHAlEPRLLDDPLVVSIARRVEKTPAQVLLAWGIQ 256 Mycobacterium colo...
BAY21124  176 VKEIFEaARIKPAVVHVESHPYlPQWELLDYCRNSGIVMQAFAALGHSsEPKLLEDPAIAAIAKRVNKTSAQVLLAWGIQ 255 Calothrix sp. NIES...
OQP44846  165 LRTIYEsARIKPAVVQVEAHPYlPETELLDFCKNNGITLLAFAPLGHGiRPGPIEDPVVLSIAARVKKTPAQVLLAWAIQ 244 Niastella yeongjue...
Feature 1          ######  #  ##                                     
NP_772896 255 RGTAFLTTSTNPARIRENFDISALPEDAMREIRDgitTNVRFNAVVETGVPGFIP 309 Bradyrhizobium japonicum USDA 110
OYQ25369  259 RGVAFLTTSATPSHIRENFDISTLPQRAMVEIQNditTRIRFNSVVETGVPGFIP 313 Pseudomonas mandelii
SIO71754  256 RGGALLTTPKSATRARENFDISALPADAFDAINRi-eTRQRFNEVVKTGSPGFIP 309 Burkholderia sp. GAS332
SPE60422  256 RGTALLTTTKNPSRIKENFDVSTIPEDAMREINEgikLRLRLNPVVETGVPGFIP 310 Verrucomicrobia bacterium
SPF36080  255 RGTAPLTTSTNPDHIRENFEISTLPEEAMQEINEgikTRYRFNVVVETGVPGFIP 309 Syntrophobacter sp. SbD1
AGA28914  256 RGTALLTTSKTPSRIKENFEVSTLPQDAMREINEgikSRIRFNAVVDTGVPGFIP 310 Singulisphaera acidiphila
OMC21462  257 RGTAVLTGSVTPARIRENFDVTALPEDAIQEINErleTRYRFNSVVDAGQPGFAE 311 Mycobacterium colombiense
BAY21124  256 RGTALLTTSKTPSRIKENFDISILPEDAMREISEgikSRVRFNTVVETGVPGFIP 310 Calothrix sp. NIES-2100
OQP44846  245 RGTAVLTTARTAARVQENFDITPLPDEAIEEINRi-qTRQRFNNVVNTGVPGFIP 298 Niastella yeongjuensis

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