Conserved Protein Domain Family
AKR_AKR5B1

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cd19127: AKR_AKR5B1 
AKR5B family of aldo-keto reductase (AKR)
Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Statistics
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PSSM-Id: 381353
Aligned: 9 rows
Threshold Bit Score: 472.277
Created: 18-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   ###                      #   ##                        #          
Q02198      8 INLNNGVKMPALGLGVFaasaEETASAIASAISSGYRLIDTARSYnNEAQVGEGIRNSGvdRAEMFVTTKLFNcdyGYER 87  Pseudomonas putida
EKP94067    8 ITLNNGVTMPLLGLGVYltppDQAAAAVAAAVACGYRLIDTAAAYnNERQVGEGIRRSGidRSAIFLTTKLWIadyGYDS 87  Thermaerobacter su...
KIC61927    9 IKLNNGVEMPVLGVGSFalptIQAADDIAFALQNGYRLVDTATNYgNEKEVGEGIKRSGvkRSELFVTTKLWIedfGYDN 88  Chryseobacterium t...
OUO49369    6 IVLNNNVRMPQIGFGVFqipaNECADVVGTALGAGYRLVDTAQTYcNEREVGRGIRESGlaRSDIFVTTKVWVteyGKEK 85  Desulfovibrio sp. ...
APO71174    8 TTLSNGVDMPLLGLGVYrsspEDTVQAVSTALATGYRLIDTAAAYrNEEQVGEAMRQSAvdRADVFVITKLWIsdyGYDE 87  Rhizobium gallicum
ANC31828    9 LTLSNGVEMPALGFGVFqtppDETTTAVTEALRVGYRHVDTAAAYgNEAGVGEALRRSGldRSDVVVETKVWAsdyGYDE 88  Isoptericola dokdo...
OZB87969    7 VTLNNGLEIPALGFGVFqtppAETIAAVTTALNDGYRLIDTAASYgNEREVGEGIRASGidRSDIVIESKLWIsdyADGK 86  Microbacterium sp....
EER61779    9 IKLNNGVEMPTLGLGVFqssaEDTVKAVTTAIADGYRLIDTASAYkNERQVGEGIRNSGipREQLFVTTKLWLtdyGYDA 88  Acidovorax delafie...
OIQ48934    7 YTLNNGVQMPAFGLGVFqsspEETIGAVSSAIAEGYRLIDTAARYvNEREVGEGIRQSGvdRNEIFVTTKLWFtdyGYDA 86  Pseudodesulfovibri...
Feature 1                           ##                              ##                    #   
Q02198     88 ALRAFDESLGRLGlDYVDLYLLHWPtkd-wnATIQSWKAAEKILGDGRARAIGVCNFlEDQLDELIAASdvvPAVNQIEL 166 Pseudomonas putida
EKP94067   88 ALRAFEASLRRLGvDHVDLYLLHWPvpmrfdDTVAAYRAAIRLLEEGRVRAIGVSNFgPRHLEELIARTgvvPAVNQVEL 167 Thermaerobacter su...
KIC61927   89 AIKGFENSLKLLGlDYIDLYILHWPvptdfdKTVQAYKALEKLYVDKKIRAIGVSNFtIEHLENLMKQTsvvPAINQVEL 168 Chryseobacterium t...
OUO49369   86 TRRSLDASLERLGlDYVDMVLLHFPvphvfeRTIEAWQDLEKELANGRVRAIGVCNFhIPHLERLMDACtvvPAVNQVEL 165 Desulfovibrio sp. ...
APO71174   88 TLRGFDRSMRKLGlNGIDLYLLHQPmpneweRTVSSWKALARLFDEGRTRAVGVSNFnSELLADLIDRTgfvPHVNQVEL 167 Rhizobium gallicum
ANC31828   89 TLHAFEKSSAKLGlEQIDVLILHQVaanlfdRTIDAYRALERLLADGRVRAIGVSNFpVARLTQLMDATdvvPHLNQVEL 168 Isoptericola dokdo...
OZB87969   87 AEVGFDASLRRLGvDYVDLYLLHQPtpadfdDTIAAYQLLEHKLAEGKVRAIGVANFsPDHLTRLIDKTtvvPAINQVEL 166 Microbacterium sp....
EER61779   89 ALRGFDGSLAKLGlDYVDLYLLHWPtkn-fdATVQSYKAAEKLLATSRVRAIGVCNHtEQHLDALIASTdviPAVNQVEL 167 Acidovorax delafie...
OIQ48934   87 ALRAFDNSLSQLGlDELDLYLLHWPvptdfdNTIAAWQALEKLLAEGRVRAIGVSNFsPQHLKRLAEHAtvvPAVNQVEL 166 Pseudodesulfovibri...
Feature 1                           #######                    #           #              ####
Q02198    167 HPYFaQKPLLAKNRALgIVTEAWSPIGGAindgdgdnhggrkhplTDPVITTIAEAHGRSAAQVILRWHFQNDVVAIPKS 246 Pseudomonas putida
EKP94067  168 HPFFtQVELRRFHDRLgIVTQAWSPIGGVlrrrgeg---gggdvlDHPVVAGLARKYGKTPAQVVLRWHLEHGIAAIPKS 244 Thermaerobacter su...
KIC61927  169 HPYLiQKDLRGFHKNHgIVTECWGPIGGEltnsasnp-tapirllQDYTIVKLAEKYKKVTAQIVLRWHVQNGMIAIPKS 247 Chryseobacterium t...
OUO49369  166 HPYFsQESLMDFHARHgIATQAWSPLGAVmiydaagi-sepvhvlQDETLCALAQRYGKSPAQIVLRWHLQRGVAIIPKS 244 Desulfovibrio sp. ...
APO71174  168 HPFFtQEDLRATHQRLrIATQAWSPIGGVmryvsdhp-eaapsplSHTTVADLAEKHGKTPAQIILRWHLQHGFSAIPKS 246 Rhizobium gallicum
ANC31828  169 HPYHsQPALQEFHREHgILTQAWSPIGGItfypgpwg-derrsvmDDPTITEIAAAHGASPAQVMLHWHLQQGRSAIPKS 247 Isoptericola dokdo...
OZB87969  167 HPYFtNATVQHADTTLgIRTQAWSPIGGIhryrpsda-pgagnvlEHPVITELATKYGKTPAQIVLRWHLEEGRSAIPKS 245 Microbacterium sp....
EER61779  168 HPYFsQKALRNKSTSLgIVTEAWSPIGGVkrywpgasstgngdplVDSVITGIAKAHGKTPAQIVLRWHLQNQVVAIPKS 247 Acidovorax delafie...
OIQ48934  167 HPFFaQRQLREANAQLgIVTQAWSPIGGIrrygkpgd-qegqdplSHPLITGLAQKYGKTAAQIILRWHMDIGVSAIPKS 245 Pseudodesulfovibri...
Feature 1     ##  #  ##                    
Q02198    247 VNPERIAKNIDVFDFALSDAEMAQLDELD 275 Pseudomonas putida
EKP94067  245 VRPERIRENIDIFDFRLAPEEVAAIDALD 273 Thermaerobacter subterraneus
KIC61927  248 QHYERLLYNIDIFDFELTADDMAAIDNLN 276 Chryseobacterium taiwanense
OUO49369  245 VHEERIRQNLDILDFALSDEDMALVNGLN 273 Desulfovibrio sp. An276
APO71174  247 VRAARITENIDVFDFVLSVDEMAAIDALG 275 Rhizobium gallicum
ANC31828  248 VNPDRIRQNLDVMGFTLSAEDLARIDALD 276 Isoptericola dokdonensis
OZB87969  246 THPNRIAENLDVFGFRLTAEDLAAIDRLD 274 Microbacterium sp. 14-71-5
EER61779  248 VSAVRIAENIDIFDFVLNDTQMAKIDALD 276 Acidovorax delafieldii
OIQ48934  246 VKPARIAENFDIFDFSLTADEVSAVTALD 274 Pseudodesulfovibrio hydrargyri

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