3D3F,1VBJ


Conserved Protein Domain Family
AKR_AKR5A_5G
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cd19126: AKR_AKR5A_5G 
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AKR5A and AKR5G families of aldo-keto reductase (AKR)
The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Links
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Statistics
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PSSM-Id: 381352
Aligned: 6 rows
Threshold Bit Score: 459.981
Created: 11-May-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1VBJ: Trypanosoma brucei prostaglandin F synthase in complex with cofactor NADP; contacts at 4A.
  • Structure:3D3F: Bacillus subtilis YvgN in complex with cofactor NADPH, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ###                       #   ##                        # #       
3D3F_A      8 VKLHNGVEMPWFGLGVFkvengNEATESVKAAIKNGYRSIDTAAIYkNEEGVGIGIKESGvaREELFITSKVWNedqGYE 87  Bacillus subtilis
1VBJ_A     12 LKLSNGVMMPVLGFGMWklqdgNEAETATMWAIKSGYRHIDTAAIYkNEESAGRAIASCGvpREELFVTTKLWNsdqGYE 91  Trypanosoma brucei
PTY08860   22 VTLNNGARMPWLGLGVWqipsdDETERVVATALSAGYRSIDTAALYrNERGVGNAIRASGvpREQLFVTTKVWNddmRAD 101 Opitutaceae bacter...
EPF25351    7 ITLNNGILMPKFGLGVYka--gDATIRAVRTALECGYRLIDTAAFYnNETQVGKAIRESGvpREEVFVTTKMWNqdqRDN 84  Treponema socranskii
NP_696457   7 IMLNNGTVIPQVGLGVFqtpdgDTTVNAVQTALENGYRHIDTAMIYhNEASVGEGIRRAGvpRSDFFLTTKLWNddiRAR 86  Bifidobacterium lo...
KZM49780   11 VELNNGTRMPWLGLGVFqm-sdDEARQACLHALDAGYRSLDTAAVYkNETGVGQALRETAfsRDELFVTTKLWNddqRAR 89  Labrenzia sp. OB1

Feature 1                            ##                           ##                    #     
3D3F_A     88 TTLAAFEKSLERLQlDYLDLYLIHWPgkdKYKDTWRALEKLYKDGKIRAIGVSNFqVHHLEELLKDAeikPMVNQVEFHP 167 Bacillus subtilis
1VBJ_A     92 STLSAFEKSIKKLGlEYVDLYLIHWPgkdKFIDTWKAFEKLYADKKVRAIGVSNFhEHHIEELLKHCkvaPMVNQIELHP 171 Trypanosoma brucei
PTY08860  102 RVEQAFDDSLRKLGlDYVDLYLLHWPiagKIVRSWQALERLQRGGQVKSIGVSNFmIPHLEELFASArvsPAVNQIEYHP 181 Opitutaceae bacter...
EPF25351   85 RQEDAFHESLNKLKlDYIDLYLIHWPvpgKFIDTWKYMEDFLASGKVRAIGVSNFlEHHLEELAAVSnvvPAVDQFECHP 164 Treponema socranskii
NP_696457  87 RGKDAFQESLDRLGvDYVDLYLIHWPa-dGWQQAWDDLQEIYASGRAKAIGVSNFqKHHIDELLTHSdvvPAVDQVESSP 165 Bifidobacterium lo...
KZM49780   90 RASSAFQESLDRLGtDYVDLYLVHWPvreHIAETWKAMEDIYSSGRAKAIGVSNFlPHHLEKLLAVAdvvPTVNQVEFHP 169 Labrenzia sp. OB1

Feature 1                         #######    #                #              #####   #  ##    
3D3F_A    168 RltQKELRDYCKGQgIQLEAWSPLMQGq--lLDNEVLTQIAEKHNKsVAQVILRWDLQHGVVTIPKSIkEHRIIENADiF 245 Bacillus subtilis
1VBJ_A    172 LlnQKALCEYCKSKnIAVTAWSPLGQGh--lVEDARLKAIGGKYGKtAAQVMLRWEIQAGVITIPKSGnEARIKENGNiF 249 Trypanosoma brucei
PTY08860  182 YlqSRDVVAFCRSKgIQMQAWSPLMQGgr-vLTDPVVVRIAETHRKtPAQVVLRWDMQGGVITIPKSVhASRIRENADvF 260 Opitutaceae bacter...
EPF25351  165 FltRESLREYCALHsIVPEAWSPLGRGi--vLESRTIAEIAKAHKKsAAQVTLRWDYQNGIITIPKSVdPKRIKENADiF 242 Treponema socranskii
NP_696457 166 QftNQELIGQLRAKgIHTEAWSPLGGTggnlLSNPVLAGIGAKYGRsAAQVVIRWHIQRGIVVLPKSThAERIKQNFEvF 245 Bifidobacterium lo...
KZM49780  170 YlvQPDLLGFCKDHkIVVEAWSPLMQGq--vASEKTFAALGEKYGKtPAQIVLRWDLQHGLVTIPKSVrASRIQENAGiF 247 Labrenzia sp. OB1

Feature 1                     
3D3F_A    246 DFELSQEDMDKIDALN 261 Bacillus subtilis
1VBJ_A    250 DFELTAEDIQVIDGMN 265 Trypanosoma brucei
PTY08860  261 NFELSDAEMAAITALE 276 Opitutaceae bacterium EW11
EPF25351  243 DFSLTEDEMEKISDLD 258 Treponema socranskii
NP_696457 246 DFNLSVDDMTAISAIN 261 Bifidobacterium longum NCC2705
KZM49780  248 DFELSEADMSVLDALD 263 Labrenzia sp. OB1

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