Conserved Protein Domain Family
AKR_AKR3G1
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cd19123: AKR_AKR3G1 
AKR3G family of aldo-keto reductase (AKR)
Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Links
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Statistics
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PSSM-Id: 381349
Aligned: 10 rows
Threshold Bit Score: 472.666
Created: 25-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Gluconobacter oxydans Gox0644 (3WBW) binds cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ###                       #    #                             # 
P74308     10 MKYFPLSNGEQIPALGLGTWKSsp-qvVGQAVEQALDLGYRHLDCAAIYgNEAEIGATLANAFt-kGVVKREELWITSKL 87  Synechocystis
PHR68226    1 MKTLTFDNGDTLPMLGLGTWKSep-geVYKAVKSAIEAGYRHIDCAHIYgNEDEIGKALNDVFa-aGTVTREELWITSKL 78  Alcanivorax sp.
SDL74977    1 MKTLKFSNNDEIPAIGLGTWKSek-gkVQEAVKIALNEGYRHIDCAAIYdNEAEIGNALSEVFs-qGKIRREDVWITSKL 78  Salinimicrobium ca...
KGO34070    1 MSLQPDRNNPLIPIIGLGTWKSkp-gqVYAAVKEAITAGYRHIDCAPAYdNESEVGAAIGEMIk-tGTVTREDLWVTSKL 78  Desulfobulbus sp. ...
KJE90815    4 VKQFILSTGATIPAIGFGTWRAsp-geAGEAVKRALEAGYRHIDCAAFYgNEAEIGATAFAPLfqsGKIARKDVFVTSKL 82  Capsaspora owczarz...
PFX19904    3 SAAVKLNNGALMPSIALGTWKSkk-geVGRAVRLALQYGYRHIDCAHVYqNEDEIGETLTEVFn-eGKVKREDIFITSKL 80  Stylophora pistillata
SFL12091    1 MRSKTLSTGYKMPMLGLGTVNFge-gkTYPALRAALKAGYRHIDCAMMYdNEAEIGQAIADAMk-eEGIKRSELFITSKL 78  Pseudovibrio ascid...
BAM54879    1 MKYFPLSNGEQIPALGLGTWKSsp-qvVGQAVEQALDLGYRHLDCAAIYgNEAEIGATLANAFt-kGVVKREELWITSKL 78  Bacillus subtilis ...
OQY27938    1 MKTLQFTNGDLMPILGLGTWGSaepsvVYSTIKQAVSIGYRHIDCAFIYgNEAEIGQALSDSFkkeSLITRDQMWITSKL 80  Candidatus Cloacim...
PIE22535    1 MRTLRFSGGQEMPALGLGTWKSkp-geVGQAVKAAIELGYRHFDCAAIYmNEKEIGAAFAECLg-qGLVKREDLWVTSKL 78  Planctomycetes bac...

Feature 1                                    ##                                               
P74308     88 WSNaHHPDAVLPALEKTLQDLgLDYLDLYLIHWPVVIQPDVGFPesgdqll-pftpasLEGTWQALEKAVDLGLCHHIGV 166 Synechocystis
PHR68226   79 WNSdHAPEDVQPALETTLRNLqLEYLDLYLMHWPVALKPGVPFPksaddmv-slkelpVETTWAAMEALVDNNLTRQIGV 157 Alcanivorax sp.
SDL74977   79 WNDsHKKEDVIPALRQTLKDLqLKYLDLYLIHWPVAFRHGVGFPtknedyl-sleevpIIETWNAMLEAKKQGLVKHVGV 157 Salinimicrobium ca...
KGO34070   79 WNNaHQPDQVLPALLKTLHDLrLDYLDLFLIHWPVAFKAEVGYPrsredwl-slaempLIDTWRAMEECVGKGVARHIGV 157 Desulfobulbus sp. ...
KJE90815   83 WNTeHDPKDVRPALIKTLADLqLDYLDLYLMHWPVALQRGAIRDadgnll---dlpipLADTWRAMEQLYDEGLVKAIGV 159 Capsaspora owczarz...
PFX19904   81 WCNsQAPEDVLPACETTLKNLqLKYLDLYLIHIPLAFKKDVPFPhskadgvigyspegMAKTWQAMEQLVDKGLCKAIGI 160 Stylophora pistillata
SFL12091   79 WNSfHKPEDVRGALEKTLADLqMEYLDLYLMHWPVALKTGVKKPtssadyy-sledvpLMDTWRALEECFDDSLANTIGV 157 Pseudovibrio ascid...
BAM54879   79 WSNaHHPDAVLPALEKTLQDLgLDYLDLYLIHWPVVIQPDVGFPesgdqll-pftpasLEGTWQALEKAVDLGLCHHIGV 157 Bacillus subtilis ...
OQY27938   81 WSDsHLPEDVQPALEKTLEDLqLDYLDLYLMHWPIALKKGVFLPesaedmi-slddlpLSETWKAMEALVDKGLCRHIGV 159 Candidatus Cloacim...
PIE22535   79 WNDkHAAADVRPALEQTLADLqLDYLDLYLMHWPLALQKGVLIPrspesfl-piseipVESTWAAMESCAEAGLVRHLGV 157 Planctomycetes bac...

Feature 1     ##                    #                         #######                         
P74308    167 SNFSLKKLEMVLSMARipPAVNQVELHPYLQQSDLLTFANSqnILLTAYSPLGSGDRPaafqqaaepkLLTDPVINGIAA 246 Synechocystis
PHR68226  158 SNFSVKKLQDLIGKARykPAMNQIELHPYLQQKEMLAFCQQqgIHLTAYSPLGSFDRPaglkaedepvLLEDPVIREIAD 237 Alcanivorax sp.
SDL74977  158 SNFSVKKLKDLMAQTQefPEMNQVELHPFLQQHELLEFCKEnnIHLTAYSPLGSGDRNkemkaenepsLLEEPVILKIAE 237 Salinimicrobium ca...
KGO34070  158 SNFSIPKLDDLHRQATipPLMNQVEIHPYLQQQAMLDYCRDrgIMLTAYSPLGSGDRPkalksagepvLLQDPVLQGIAD 237 Desulfobulbus sp. ...
KJE90815  160 SNFTSVKIDKLLTTARvaPVVNQVEISPYLQQRKLVAYCEGkgIHVTGYATLGSGQTPr---------ALDDPIIGQIAA 230 Capsaspora owczarz...
PFX19904  161 SNFTTKKTRTLLETARivPACNQVELHPYLPQPQLLKFSADkgIVVTAYSPLGSPDRPsankd-sepvILENPVLKKIAE 239 Stylophora pistillata
SFL12091  158 SNFSTHKLEDLIMEARvvPAVNQVELHPFLQQNDLRSYCLHnnIALTAYSPLGRGVPAdltdaqkqdvVLAHPVIEEIAG 237 Pseudovibrio ascid...
BAM54879  158 SNFSLKKLEMVLSMARipPAVNQVELHPYLQQSDLLTFANSqnILLTAYSPLGSGDRPaafqqaaepkLLTDPVINGIAA 237 Bacillus subtilis ...
OQY27938  160 SNFSVVKLRGLLADARlkPEMNQIELHPYLQQPEMLDFCREngIHLTAYSPLGSPGRPpiikvegepvLLDDPTIAKIAE 239 Candidatus Cloacim...
PIE22535  158 SNFSVHKLASLAASAQhkPELNQVEMHPYLAQPQLVEWCVAnsVQLTAYSPLGSPDRPssmraedeprLFEDPVIVDIAK 237 Planctomycetes bac...

Feature 1           #               ######  #  ##                          
P74308    247 EQGcsAAQVLLAWAIQr-GTVTIPKSVNPERLEQNLRAaDITLTDSEMAKIALLDRHYRYV 306 Synechocystis
PHR68226  238 HHGasPAQVLISWALHr-NTVVIPKSVNPERLKQNLAAaELSLSDADMDAIGALDKHRRYV 297 Alcanivorax sp.
SDL74977  238 KHSasPGQILIQWAVAr-GTAVIPKSTSKGHIIANLESdKIELDEADMKEIAELDRHFRYV 297 Salinimicrobium catena
KGO34070  238 RHRcaVSQILLAWAMAr-GVIVIPKSVEPKRIRQNLDAvKVELDAEDMAAIAGLDRGHRYV 297 Desulfobulbus sp. Tol-SR
KJE90815  231 KHNvsAAQVMINWCAYvnNCSVIPKSTNPERIQANFNSkDVKLDASDIATLQSLDRGLRLF 291 Capsaspora owczarzaki ATCC 30864
PFX19904  240 KHGttTALVALAWGIKr-NTPVLPKSVSENHIKENLEAlHVNLDEDDMKTIENIGIHHRYL 299 Stylophora pistillata
SFL12091  238 KHGatTSQVVLKWAIQn-GVIVVPKSGNPERLAQNLAAsECDLDEHDMSRIAHLDKNHRFI 297 Pseudovibrio ascidiaceicola
BAM54879  238 EQGcsAAQVLLAWAIQr-GTVTIPKSVNPERLEQNLRAaDITLTDSEMAKIALLDRHYRYV 297 Bacillus subtilis BEST7613
OQY27938  240 QHGitPAQVLISWAIHr-NTGVVPKSFNPKRMQQNFTAtEASLSQNDMQDISDIDKNHRYF 299 Candidatus Cloacimonetes bacterium 45...
PIE22535  238 AHSmhPAQILIAWAVNr-GSSVIPKSVNRERMAQNLVAaELELSAEEMQRLNALDRHHRLI 297 Planctomycetes bacterium

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