4IJC


Conserved Protein Domain Family
AKR_AKR3C1
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cd19119: AKR_AKR3C1 
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Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins
Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Links
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Statistics
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PSSM-Id: 381345
Aligned: 5 rows
Threshold Bit Score: 492.783
Created: 16-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ###                           #   ##                           
4IJC_A     22 EIYFSLNNGVRIPALGLGTAnphe--klaETKQAVKAAIKA-GYRHIDTAWAYeTEPFVGEAIKELLEDgsikREDLFIT 98  Saccharomyces cere...
P38115     22 EIYFSLNNGVRIPALGLGTAnphe--klaETKQAVKAAIKA-GYRHIDTAWAYeTEPFVGEAIKELLEDgsikREDLFIT 98  Saccharomyces cere...
OBA17045    3 SVLLPLNTGALMPAIGLGTWspd---drsQIRECVEYAILEaGYRHIDTAYLYgCEDQVGQAVRNAIATgkvtREELFIT 79  Ogataea polymorpha
CAG77909    4 TDSFKLNDGHSIPALGLGTAsd------gNVEEVVYAAIKN-GYRHIDTAFIYgSEVDVGKGIKRAIDEelvkRENLFVT 76  Yarrowia lipolytic...
OUM51451    4 IKSVKLNTGASIPLIGLGTWvpvdhsdreIVASTIEYAISEaGYRHLDTAYYYeTEDKIGEALKRIFDKgeikREEVFIT 83  Candida boidinii

Feature 1      #                              ##                                              
4IJC_A     99 TKVWPvLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFekikdpkgisglvktPVDDSGKTMYAAd-GDYLETYKQLEKI 177 Saccharomyces cere...
P38115     99 TKVWPvLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFekikdpkgisglvktPVDDSGKTMYAAd-GDYLETYKQLEKI 177 Saccharomyces cere...
OBA17045   80 TKVWPtFHKHMEDGLDLSLKASGLDYFDLVLVHWPIPFkcdsdd----gkpfwPKNKDGYIARDMs-SDHITMYQQLEKC 154 Ogataea polymorpha
CAG77909   77 TKVWPtFYNRVSESLDISLKDLSLDYVDLLLVHWPVSLladsdd----praiyLVNTDGSVRYSDslDDWITTYKQIEEE 152 Yarrowia lipolytic...
OUM51451   84 TKIWPtFYDKVEYCLDKSLKDLQLDYVDLLLVHYPVCLyrenee---tgkpfiPEYPNGLTRKAKg-FDHVDMWKQMEEI 159 Candida boidinii

Feature 1                   ##                    #                         #######           
4IJC_A    178 YLDpndhRVRAIGVSNFsIEYLERLIKECrvkPTVNQVETHPHLPQMELRKFCFMHdILLTAYSPLGSHGAPn--LKIPL 255 Saccharomyces cere...
P38115    178 YLDpndhRVRAIGVSNFsIEYLERLIKECrvkPTVNQVETHPHLPQMELRKFCFMHdILLTAYSPLGSHGAPn--LKIPL 255 Saccharomyces cere...
OBA17045  155 LENg---KAKAIGVSNYsIPKLESLLKVCkyvPAVNQCELHPLLPRRDLCDFCTSRgIVMTSYFPFGGNGAPi--LKNEA 229 Ogataea polymorpha
CAG77909  153 KLSg---RTKSIGVSNVsEVYLKRLLDQVktvPAVNQFEIHPYLPQKKEIEFNEKHgILVTAFSPLGSSTGAlklHENPI 229 Yarrowia lipolytic...
OUM51451  160 YKKg---KAKAIGVSNYsEVFIEELIEKCeivPAVNQIELHPRLPQLDLVDYCKKKgIVVTAFSPFGGGRHGapmIFNED 236 Candida boidinii

Feature 1     #           #              ######  #  ##                          
4IJC_A    256 VKKLAEKYNVtGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFaSLTKDELQELNDFGEKYPVRFI 321 Saccharomyces cerevisiae S288c
P38115    256 VKKLAEKYNVtGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFaSLTKDELQELNDFGEKYPVRFI 321 Saccharomyces cerevisiae S288C
OBA17045  230 IAEIAKKYSVsSSTILLSYHVNMGVSVVPKSFKPHRIKLNGKIvYLQKEDLEKLMEIGREKPHRFN 295 Ogataea polymorpha
CAG77909  230 AVEIAQKHNTsTGSVLINWHVSQKRAVLPKTRSIERVVANGMKvPLDQGDLDKLDKIWLQTGTQRA 295 Yarrowia lipolytica CLIB122
OUM51451  237 VIKMAEKYNCsTGNILVNYHYVNDVVCLPKSAKPDRLVDNLKIiGLTDEDRKFLDTLADKYGILRK 302 Candida boidinii

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