Conserved Protein Domain Family
AKR_AKR3B1-3
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cd19118: AKR_AKR3B1-3 
AKR3B family of aldo-keto reductase (AKR)
Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Links
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Statistics
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PSSM-Id: 381344
Aligned: 11 rows
Threshold Bit Score: 471.51
Created: 18-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                      #   ##                                     
P27800         7 LNTGASLELVGYGTWQaaPGEVGQGVKVAIETGYRHLDLAKVYsNQPEVGAAIKEa-------------gVKREDLFITS 73  Sporidiobolus s...
EPQ30077      10 LNTGAKMPAIGLGTWLakPDEVRVAVKTALEQGYRHIDAARVYgNEHEVGQALSEsiq---------agiLKRDDVFITS 80  Pseudozyma floc...
XP_022204737   9 LNTGHQMPQLGYGTWQaePGEVAAGVLEALRTGYRHLDLAKVYgNQAEVAIGLRRglae--------ipgLDRGQLFITS 80  brown planthopper
KIM82391       9 LSSGRTIPQIGLGTWLaePGEVKAAVEIAIKHGYRHLDLAMCYeNQSEVGQALAEflpnakgvfphpevkVERKDLFITS 88  Piloderma croce...
ELA31967      14 LNNGNQIPIIGLGTYLskPNEVRDAVLAGWRCGMRHFDCAQFYqNEKEIGSAIETlrke--------epaFKREDLFITS 85  Colletotrichum ...
Q0GYU5         9 LNTGYKIPQIGYGTWQaaPGEVGAGVFEALKVGYRHLDLAKVYgNQKEVGEGIKKalae--------vpgLKREDIFITS 80  Trichoderma reesei
BAD90687       9 LNDGNSIPALGYGTWQaePGQVGEGVKLAVKAGYRHLDLAKVYqNQTEIGQALKElfd---------egvVKREDLFITS 79 
BAD90688       9 LNDGNSIPALGYGTWQaePGQVGEGVKLAVKAGYRHLDLAKVYqNQTEIGQALKElfd---------egvVKREDLFITS 79 
BAD90689       9 LNDGNKIPALGFGTWQaePGQVGASVKNAVKAGYRHLDLAKVYqNQSEIGVALQElfd---------qgiVKREDLFITS 79 
KEP51715       9 LNDGRVIPAIGLGTFLskPDEVTKAVEIAVNAGYKHFDLATCYqNEHEVGIALSNlkks--------npnFKREDLWLTG 80  Rhizoctonia sol...
AAB17362       7 LNTGASLELVGYGTWQaaPGEVGQGVKVAIETGYRHLDLAKVYsNQPEVGAAIKEa-------------gVKREDLFITS 73 

Feature 1        #                                ##                                             
P27800        74 KLWNNSHrpeQVEPALDDTLKELGLEYLDLYLIHWPVAFppegditqnlfp----------kandkevkldleVSLVDTW 143 Sporidiobolus s...
EPQ30077      81 KLWNTDHapeRVEAGLRRSLRDIGVEYLDLFLVHWPIAFkgtadenvlfpr-----------ndqgqidvdtsQSIAATW 149 Pseudozyma floc...
XP_022204737  81 KLWNTKHrpaDVEAALDDTLAELQLDYLDLYLIHWPVAFrpgdethpttt------------gnpdkidldrsVSVCQTW 148 brown planthopper
KIM82391      89 KLWNCSHqreYAVRELDETLNQLGIDYLDLYLVHWPVAYepgnglnpmhp------------tkenqrhldlkTTVIETW 156 Piloderma croce...
ELA31967      86 KAWNSHHrpeNLKKALDQTLKDLGTDYLDLYLIHWPVNFaavgdaksdtgvkl-------epseggnmlldrqLSLTATW 158 Colletotrichum ...
Q0GYU5        81 KLWNNSHkpeDVEPALDDTLAELGLDYLDLYLIHWPVAFapgadlfpkse-------------dgsevqlnqnVSIVQTW 147 Trichoderma reesei
BAD90687      80 KLWNNRHapeHVEPALDETLKELGLSYLDLYLIHWPVAFkfttpdellpad----------ptnkdlayvddsVKLSDTW 149
BAD90688      80 KLWNNRHapeHVEPALDETLKELGLSYLDLYLIHWPVAFkfttpdellpad----------ptnkdlayiddsVKLSDTW 149
BAD90689      80 KVWNNRHapeHVEPALDETLKELGLSYLDLYLIHWPVAFkfttpqelfpte----------pdnkelaaiddsIKLVDTW 149
KEP51715      81 KTWNSFHrqeYITKGLDQTLKDLGTDYLDLYLVHWPVHFkpqpspdgknavrilplstnpvnldipevaldteLSCTEVW 160 Rhizoctonia sol...
AAB17362      74 KLWNNSHrpeQVEPALDDTLKELGLEYLDLYLIHWPVAFppegditqnlfp----------kandkevkldleVSLVDTW 143

Feature 1                         ##                       #                           #######   
P27800       144 KAMVKLLDTgKVKAIGVSNFdaKMVDAIIEatg---vtPSVNQIERHPLLl--QPELIAHHKAKnIHITAYSPLGNNtvg 218 Sporidiobolus s...
EPQ30077     150 AKMVEMKRKgLVRAIGLSNVskDMVQAVCDaaqsddevPSSVQVEYHPLVaplQRELKDYCDSKkIILTAYSPLGNNrig 229 Pseudozyma floc...
XP_022204737 149 KAIIQLPKS-KVRSVGVSNFsiKHLEAVIQdsg---vvPAVNQIERHPRLp--NTALLDYCXRQkIVTTAYSAFGNNslg 222 brown planthopper
KIM82391     157 ETMIALKKTgKVKDIGVSNFsiDYIKGITKtgl---emPVVNQIEMHPLLl--QNNLVNFCNQHkIHITAYSPLGNNlvg 231 Piloderma croce...
ELA31967     159 EAMIEVQKAgKVKSIGVSNFspAHIQKLIDetg---vvPAVNQVEAHPLLi--QQELLDYCTSKgIHITAYMPFGGDaar 233 Colletotrichum ...
Q0GYU5       148 KAMTELPKS-KVRSVGVSNFtiEHLDAVIEatg---vvPAVNQIERHPRLp--NQPLIDYCAKKgIIITAYSAFGNNtkg 221 Trichoderma reesei
BAD90687     150 KAVVALKKTgKTKSVGVSNFs-TRLVDLVEeas--gerPAVNQIEAHPLLq--QDELVAHHKSKnIVITAYSPLGNNvag 224
BAD90688     150 KAVVALKKTgKTKSVGVSNFs-TRLVDLVEeas--gerPAVNQIEAHPLLq--QDELVAHHKSKnIVITAYSPLGNNvag 224
BAD90689     150 KAVVALKKTgKTKSVGVSNFt-TDLVDLVEkas--gerPAVNQIEAHPLLq--QDELVAHHKSKnIVITAYSPLGNNvsg 224
KEP51715     161 KLMIQLRETgKVKSIGVSNFpvRILKTIIAetg---vvPAVNQVEAHPLLl--QDDLVEYCKEQnIHISAYAPLGNNlqg 235 Rhizoctonia sol...
AAB17362     144 KAMVKLLDTgKVKAIGVSNFdaKMVDAIIEatg---vtPSVNQIERHPLLl--QPELIAHHKAKnIHITAYSPLGNNtvg 218

Feature 1                  #                 #              ######  #  ##                   
P27800       219 -aplLVQHPEIKRIAEKNGc------tPAQVLIAWAIVgGHSVIPKSVTPSRIGENFKq--VSLSQEDVDAVSKL 284 Sporidiobolus salmon...
EPQ30077     230 -eplLVQRPTLLDVSAKTGh------tPAQILIQWIVRnGVCVIPKSVTPSRLQSNLEsldFDLSDDERNAVDAL 297 Pseudozyma flocculos...
XP_022204737 223 -lplLVADPEIKAEAARLAv------sPAQLILAWCQQgGHTVIPKSVTPDRIRENFKd--VTIDSAALAAVARL 288 brown planthopper
KIM82391     232 -lpkLTDHPVVQEIAAKHGsk----ttPAQTLIAWGAHrGFSVIPKSVHEERIRSNFEq--VELSNDEFEKISAI 299 Piloderma croceum F ...
ELA31967     234 ggarVLGNPAVDNIARKFGk------dAGQVLGSWGIKaRFSVLPKSVKASRIESNFQv--FDLDGDSYEALTEL 300 Colletotrichum gloeo...
Q0GYU5       222 -lplLVSSDEVKAVADNLSkkqgktvtPAQVILAWSQIgGHTVIPKSVTKARIAENFQe--VELDDEAIAALNKL 293 Trichoderma reesei
BAD90687     225 -kppLTENPGIVDAAKRLNh------tPAAVLIAWGIQrGYSVLVKSVTPSRIKSNFEq--ITLSDEEFQRVTNL 290
BAD90688     225 -kppLTENPGIVDAAKRLNh------tPAAVLIAWGIQrGYSVLVKSVTPSRIKSNFEq--ITLSDEEFQRVTNL 290
BAD90689     225 -kppLTQNPGIEATAKRLNh------tPAAVLLAWGIQrGYSVLVKSVTPSRIESNYDq--ITLSPEEFQKVTDL 290
KEP51715     236 -elrIIDHEVVKKLASELGk------tPAQVLIAYGVKrGYSVLPKSVNESRIRSNFEd--FELPDDAYNQLVEL 301 Rhizoctonia solani 123E
AAB17362     219 -aplLVQHPEIKRIAEKNGc------tPAQVLIAWAIVgGHSVIPKSVTPSRIGENFKq--VSLSQEDVDAVSKL 284

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