Conserved Protein Domain Family
AKR_AKR2D1

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cd19115: AKR_AKR2D1 
AKR2D family of aldo-keto reductase (AKR)
Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Statistics
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PSSM-Id: 381341
Aligned: 15 rows
Threshold Bit Score: 596.325
Created: 17-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ###                      #   ##                            #  
Q9P8R5          2 ASPTVKLNSGYDMPLVGFGLWKVNNdTCADQIYHAIKEGYRLFDGACDYGNEVEAGQGIARAIKDGLVKREELFIVSKLW 81   Aspergillus n...
NP_001134820    1 MAPSIELNSGYEMPQVGFGLWKVDKaTCADTVYNAIKAGYRLFDGACDYGNEKECGEGVARAIKESIVKREDLFIVSKLW 80   Atlantic salmon
POF05911      479 TAPTTKLNNGKEMPLVGFGLWKVTNeTCADTVYNAIKTGYRLFDGACDYGNEVEAGQGVKRAIDEGLVKREQLFIVSKLW 558  Quercus suber
PRP89518       32 RTQQELKPTGQKMPLVGFGLWKVTKsDCANTVYNAIKTGYRLFDGACDYGNEKEAGEGIRRAISDGLVKREDLFITSKLW 111  Protostelium ...
G4N708          2 ASPTMKLNNGLDMPQVGFGLWKVENsVCADVVYNAIKAGYRLFDGACDYGNEVECGQGVKRAIDEGLVKREELFIVSKLW 81   Magnaporthe o...
C5FFQ7          9 TAPAVKLNSGYAMPIVGFGLWKVNKeTCADQVYNAIRTGYRLFDGACDYGNEVEAGKGVARAIKEGIVRREDLFIVSKLW 88   Microsporum c...
Q5BGA7          2 SPPTVKLNSGYDMPLVGFGLWKVNNdTCADQVYEAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKRSDLFIVSKLW 81   Aspergillus n...
A1CRI1          2 STPTVKLNSGYEMPLVGFGLWKVNNdTCADQVYEAIKAGYRLFDGACDYGNEVECGQGVARAIKEGIVKREDLFIVSKLW 81   Aspergillus c...
Q4WJT9          2 TTPSIKLNSGYDMPLVGFGLWKVNKeTCADQIYHAIKAGYRLFDGACDYGNEVEAGKGVARAIQEGIVKREELFIVSKLW 81   Aspergillus f...
Q876L8          2 ASPTLKLNSGYDMPQVGFGLWKVDNaVCADTVYNAIKAGYRLFDGACDYGNEKECGEGVARAIKDGLVKREDLFIVSKLW 81   Trichoderma r...
Feature 1                                       ##                                                
Q9P8R5         82 NSFHDgDRVEPICRKQLADWGIDYFDLYIVHFPISLKYVDPAVRYPPGWksekd--elefgNATIQETWTAMESLVDKKL 159  Aspergillus n...
NP_001134820   81 QTFHDkEKVEPICRRQLADWQVDYFDLFLIHFPVALEYVDPSVRYPPGWfydgkc-evrwsKTTNQQTWEAMEMLVDGGL 159  Atlantic salmon
POF05911      559 NSFHDrERVKPIAQKQLADWGIDYFDLFIIHFPIALKYVDPSVRYPPGFfyend--qvalsKATLEETYHAMEALYDEGL 636  Quercus suber
PRP89518      112 NTFHAkEHVAQLARKQLADYGIDYFDLFLIHFPISLQYVDPATRYPPGWqedgk---viqtNVPHAETWAAMEKLVDEGL 188  Protostelium ...
G4N708         82 NTFHDgERVEPIVKKQLADWGIEYFDLYLIHFPVALEYVDPSVRYPPGWhyddagteirpsKASIQETWTAMEKLVDAGL 161  Magnaporthe o...
C5FFQ7         89 GTFHDpEHVEPACRRQLSHWGIDYFDLFIVHFPISLKYVDPEVRYPPEWsapge--kaesgNVPLYKTWGAMEELVDKRL 166  Microsporum c...
Q5BGA7         82 NSFHDgERVEPIARKQLSDWGIDYFDLYIVHFPVSLKYVDPEVRYPPGWenaeg--kvelgKATIQETWTAMESLVDKGL 159  Aspergillus n...
A1CRI1         82 NSFHDsERVEPICRKQLADWGVDYFDLYIVHFPIALKYVDPAVRYPPGWmsend--klefsNTPIHETWAAMEKLVDLKL 159  Aspergillus c...
Q4WJT9         82 NSFHDgDRVEPICRKQLADWGLDYFDLFIVHFPIALKYVDPAVRYPPGWlsenn--klefsNASIQETWTAMESLVDKKL 159  Aspergillus f...
Q876L8         82 QTFHDeDKVEPITRRQLADWQIDYFDLFLVHFPAALEYVDPSVRYPPGWfydgksevrwskTTTLQQTWGAMERLVDKGL 161  Trichoderma r...
Feature 1               ##                    #                         #######                   
Q9P8R5        160 ARSIGISNFSAQLVMDLLRYARIRPATLQIEHHPYLTQTRLVEYAQKEGLTVTAYSSFGPLSFLELSVQNAvdsppLFEH 239  Aspergillus n...
NP_001134820  160 TKSIGISNYQAQGIYDLLKYARIRPATLQIELHPYLQQRNLVGLAKEEGIAVTAYSSFGPTGFIELGMDRAknvapLMEH 239  Atlantic salmon
POF05911      637 IRAIGVSNYTGTLLLDVERYAKVLPQTLQIEHHPYLVQQDLLELCRSRNIAVTAYSSFGPQSFLELNLQKArdaalLFDH 716  Quercus suber
PRP89518      189 AKNIGISNFAGGLIIDLLRTARIRPAVLQVEHHPYLQQPELIKFANLEKIAVTAYSSFGPQSYIEIDFPGAkdatpLFEH 268  Protostelium ...
G4N708        162 SKAIGVSNFQAQLLYDMLRYARIRPATLQIEHHPYLVQQRLIEACKTEGIVVTAYSSFGPASFKEFNMEHAealtpLLEE 241  Magnaporthe o...
C5FFQ7        167 ARSIGISNFSPQLIMDLLRYARIRPSTLQIEHHPYLTQEGLIKYAQDEGLVVTAYSSLGPQSFIELENKAAtgttlLLEH 246  Microsporum c...
Q5BGA7        160 ARSIGISNFSAQLLLDLLRYARIRPATLQIEHHPYLTQERLVTFAQREGIAVTAYSSFGPLSFLELSVKQAegappLFEH 239  Aspergillus n...
A1CRI1        160 ARSIGVSNFSAQLLMDLLRYARVRPSTLQIEHHPYLTQKRLVDYAQKEGLAVTAYSSFGPLSFLELNLKDAhetplLFEH 239  Aspergillus c...
Q4WJT9        160 ARSIGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQERLVTYAQKEGIAVTAYSSFGPLSFVELDLKDAhetpkLFDH 239  Aspergillus f...
Q876L8        162 ARSIGVSNYQAQSVYDALIYARIKPATLQIEHHPYLQQPDLVSLAQTEGIVVTAYSSFGPTGFMELDMPRAksvapLMDS 241  Trichoderma r...
Feature 1           #           #              ######  #  ##                               
Q9P8R5        240 QLVKSIAEKHGRTPAQVLLRWATQRGIAVIPKSNNPQRLKQNLDvTGWNLEEEEIKAISGLDrGLRFNDPLGY 312  Aspergillus niger CB...
NP_001134820  240 DAIISMATKHNKTPAQVLLRWASQQGLAVIPKTSRPSVMTQNLDsTDFILDQQDMDRIAEMDlNLRFNQPTNY 312  Atlantic salmon
POF05911      717 DTITSIAAKHGKTPAQVLLRWATQRGVAVIPKSNNQGRLQQNLDvCGFDLASEEIEKISSLDqGLRFNNPLNY 789  Quercus suber
PRP89518      269 EVVVKLAKKYNKEPAQVLLRWATQRGIAVIPKSNNQKRLEQNLHcCDFDLSEEDLKSFEKLEqGMRMNNPGNY 341  Protostelium sp. Jen...
G4N708        242 PTIVKLAEKYGKDPGQVLLRWATQRGLAVIPKSSREKTMKSNFEaVGWDMEDSDIKTISALDkGIRFNQPANY 314  Magnaporthe oryzae 7...
C5FFQ7        247 PTIKSSAEKHGKTPAQILLRWATQRGIAVIPKSNNPDRLAQNLDaTGFNLTANELRAISALDqGLRFNNPPSY 319  Microsporum canis CB...
Q5BGA7        240 PVIKDIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPARLLQNLDvVGFDLEDGELKAISDLDkGLRFNDPPNY 312  Aspergillus nidulans...
A1CRI1        240 PAITAIAEKHGKTPAQVLLRWATQRKVAVIPKSNNPTRLAQNLDvTSFNLEASEIESISALDrNLRFNDPLAI 312  Aspergillus clavatus...
Q4WJT9        240 DVIKGIAQKHGRTPAQVLLRWATQRNIAVIPKSNDPTRLAQNLDvTGWDLEASEIEAISALNrNLRFNDPLAI 312  Aspergillus fumigatu...
Q876L8        242 PVIKALADKHRRTPAQVLLRWATQRGIAVIPKTSRPEVMAQNLDnTSFDLDSEDLAKIADMDlNIRFNKPTNY 314  Trichoderma reesei

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