Conserved Protein Domain Family
AKR_AKR1E1-2
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cd19110: AKR_AKR1E1-2 
AKR1E family of aldo-keto reductase (AKR)
The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Links
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Statistics
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PSSM-Id: 381336
Aligned: 4 rows
Threshold Bit Score: 645.861
Created: 5-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###                      #   ##                            #           
Q96JD6      1 MGDIPAVGLSSWKASpGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGaVRREDLFIATKLWCTCHKKSLV 80  human
Q9DCT1      1 MENIPTVGLGTWKASpGEVTDAVKLAINLGYRHFDCAYLYHNESEVGMGISEKIKEGvVKREDLFVVSKLWCTCHKKSLV 80  house mouse
P82125      1 MEKIPVLGLGTWQAApGEVTEAVKVAIDTGYRHFDCAYLYHNENEVGVGIQAKIDEGvVRREDLFIVSKLWCTCHKKSLV 80  pig
Q4R802      1 MGDIPAVGLSCWKASpGKVTEAVKVAIDAGYRHFNCAYFYHNEKEVGAGIRYKIKEGaVRREDLFIASKLWCTCHKKSLV 80  crab-eating macaque

Feature 1                          ##                                                         
Q96JD6     81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDtdFLDTWEAMEDLVI 160 human
Q9DCT1     81 KTACTNTLEALNLDYLDLYLIHWPMGFKPGEK-------------------DIPLDRNGKVIPSHtsFLDTWEAMEDLVF 141 house mouse
P82125     81 KSACTRSLKALKLQYLDLYLIHWPMGFKPGEV-------------------DLPVDRSGMIVASNtdFLDTWEAMEDLVI 141 pig
Q4R802     81 KTACRRSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshpgvhDLPLDESDMVIPGDtdFLDTWEAMEDLVI 160 crab-eating macaque

Feature 1              ##                      #                         #######           #  
Q96JD6    161 TGLVKNIGVSNFNHEQLERLLNKPGLRfKPLTNQIECHPYLtQKNLISFCQSRDVSVTAYRPLGGSCEGVdLIDNPVIKR 240 human
Q9DCT1    142 EGLVKNLGVSNFNHEQLERLLDKPGLRvRPITNQIECHPYLnQKKLIDFCHKRNVSVTAYRPLGGSGGGFhLMDDTVIRK 221 house mouse
P82125    142 EGLVRAIGVSNFNHEQLERLLNKPNLRvKPVTNQIECHPYLtQKKLISFCQSRNVSVTAYRPLGGSSEGVpLLEDPVIQT 221 pig
Q4R802    161 TGLVKNIGVSNFNHEQLERLLNKPGLRfKPVTNQIECHPYLtQKNLISFCQSRGVSVTAYRPLGGSCEGVdLIDDPVIQR 240 crab-eating macaque

Feature 1              #              ######  #  ##                                           
Q96JD6    241 IAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQvFDFELTQHDMDNILSLNRNLRLAmfPITKNHKDYPFHIEY 320 human
Q9DCT1    222 IAKKHGKSPAQILIRFQIQRNLIVIPKSVTPSRIRENIQvFDFELTEKDMEELLSLDKNLRLAtfPTTENHQDYPFHIEY 301 house mouse
P82125    222 IAQKHGKSAAQILIRFQIQRNVIVIPKSVNPKRILENFQvFDFELSEQDMTDLLGLDRNLRLSafPIAENHKDYPFKAEY 301 pig
Q4R802    241 IAKEHSKSPAQILIRFQTQRNVIVIPGSITPSHIKENIQvFDFELTQHDMDNILSLDRNLRLAtfPITKNHKDYPFHIEY 320 crab-eating macaque

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