Conserved Protein Domain Family
AKR_unchar
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cd19100: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Links
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Statistics
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PSSM-Id: 381326
Aligned: 159 rows
Threshold Bit Score: 186.534
Created: 24-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ###                                 #    #                      
NP_924840  45 RRPFGKTGVQVSIIGLGGYHlgsa-------ksdAEAVRIVHAAMDAGVNFLDNAWEYrdglSEERMGKALRgg-rRQQA 116 Gloeobacter violaceus
KPK85718    3 TRTLGRTGLTVGVIGLGTEYlld--------vprGTVVSVVRQAVAAGVNYFDVLFAQp--hYLDNLGAAFQg--lREKI 70  Phycisphaerae bact...
PIV55018    4 FRKLGSTGLKVSVVGLGTLGfarvglfnkgeegvKEISYIVNRALDLGINFVDTAFAYgngvAETGVGAVVKa--rRKDC 81  Candidatus Desanti...
AVM47301    3 YRELGGTGIAVSEVGFGGEHleg--------kesAIVERTVHAALDAGINLFDVFMSEp--nVRTNIGRGLAg--rRDRA 70  Victivallales bact...
CDA79454    3 YRTLGRTGLKVSEVGLGGEWfng--------lseEESIRIVDAAEQNGVNYIDIFMPQa--pTRDHLGAALKg--rREKF 70  Ruminococcus sp. M...
EHL69374    3 YRKLGLTGITVSEIGLGCEGfvd--------hdgRYTRELVDIAAAGGVNYIDLYSSDp--rVREGLGRALAg--rREKF 70  Synergistes sp. 3_...
CCZ81937    3 YRKLGRTGLSVSAIGLGCEGfig--------lseEDTRRQMDFAIAQGINFMDMYSSNp--gLRTNIGKALVg--yRPQF 70  Odoribacter laneus...
ALT68422    3 YRTLGNTGIKVSEIAFGAEWyve--------rpyEEVEEIVRHCENNGINFLDCWMSEp--tVRTNLGKAIKd--tRDKW 70  Methanobrevibacter...
OLS57000    3 YRVLGRTGIKVSTIGLGGGGlen--------idaVACEAIIDCSLDEGVNFLDIYNSNp--eVRSNVGKALSky-pRDSF 71  Sporomusa sphaeroides
OUO35329    3 YRKLGNTGLEVSEIGFGGEWmdr---------spEETLAVVRAAQEAGINILDCWMNDa--mRRSNLGDALRelgsRERW 71  Olsenella sp. An290

Feature 1         #                                        ##                                 
NP_924840 117 LLMSKVcthg--------rdrkVAMGQLEESLKRLgTDYLDLWQVHEViydndpe-lhfapgGVIEALEQAKKEGkVRYV 187 Gloeobacter violaceus
KPK85718   71 LITGHLgsavqdgqyrrsrdvrECEELFHDLLRRLgTEYVDVAFLSNCdeqadye-rvmgpgGLGELAVRLQREGqARFI 149 Phycisphaerae bact...
PIV55018   82 IVLSRShvwqt------sekpeDTASSIDNSLKRLnMEAIDVFEVHDVtkpesy--kmvrgkGIYDVVKKAKKDGkLRFI 153 Candidatus Desanti...
AVM47301   71 VVQGHFravwkdgqygrtldlaETKFFFQDLLDRLgTDYIDIGMIHMVdnkadf--daifngEIYRYVLELKRKGvIRAI 148 Victivallales bact...
CDA79454   71 LIQGHLctvyedeqytrtrdieKTKRSFEDLLHRLqTDYIDVGMIHYVdseedf--qtvfggEIIEYAKELKEKGiVRYL 148 Ruminococcus sp. M...
EHL69374   71 ALQGHLcttwedgqyrrtrdekEVRESFADLLRLLgTDYIDVGMIHYCdsaedw--reiadgPVMRYARELKAAGkIRHI 148 Synergistes sp. 3_...
CCZ81937   71 VIQGHLcatwengqylrtrdvdKTLAAFEEQLRLLrTDYLDIGMIHYVddekdf--rcvfegPIIRLALRLKQEGrIRHI 148 Odoribacter laneus...
ALT68422   71 VIQGHIgatwqnnqyvrtremdKVKEAFEDFMERFqMDTLDFGMVHYVdelkdy--deimsgEFIEYVRQLKEKGiIKHI 148 Methanobrevibacter...
OLS57000   72 VIQGHLcsvwdngqyrrtrdynEVVGAFEDFLRRMqLDYVDIGMLHYVddqkdf--dniftgEIITYAKELKAKGiIKSL 149 Sporomusa sphaeroides
OUO35329   72 VIQGHLgsvtvdgqytrtrdldLVRPAFEDLLERFhTDYVDLGMIHYVdkveeyervvlgdsPFMRYVRELHAAGtIRHI 151 Olsenella sp. An290

Feature 1       ##                    #                                                      #
NP_924840 188 GFTGHkdpaIHLKMLDKgypFDACQLPLNCFdasfr------------------------sfeqqVLPRLNALGIAAIGM 243 Gloeobacter violaceus
KPK85718  150 GLSGHqv-pVASKAVASg-vVDVLMHSLNLSgdatp-------------------------grkqLYHACAAQGVGLIAM 202 Phycisphaerae bact...
PIV55018  154 GFSTHgsaeMMKEMINSg-dVDVLTVAYNLTghrrmladg----------------ddirkteeeILPLCKEKGVGITIM 216 Candidatus Desanti...
AVM47301  149 GLSSHis-sIALEAVNRg-lIDVLMFSLNPAydllhqeaieeliqingtafesaeirgvsrarseLYRACDAKGVGIVVM 226 Victivallales bact...
CDA79454  149 GMSSHnp-hIAKKAAETg-lIDVLMFSINPAydlespetdindlmdf--kgmgengwvvdearqeLYSYCESAGVAITVM 224 Ruminococcus sp. M...
EHL69374  149 GVSSHnp-aAALAAVKSg-lIEVLMFSVNPCydlqpggedcealwdd--rsyeqpllnmdaereaLYEACSRLGVAITVM 224 Synergistes sp. 3_...
CCZ81937  149 GMSSHnp-rVAIKAVESg-lVDVLMFSINPCydlqpaseevedlwkd--enyerelhnidperelLYELCEQKGIGIDVM 224 Odoribacter laneus...
ALT68422  149 GLSTHnt-dIALLAAENp-eIELLMFSINPAydmfppteviedysdd---dkytdlagldprraeLYQLCEDNGMPITVM 223 Methanobrevibacter...
OLS57000  150 GISTHnp-dIAFSAVETg-lIDVILFSINAAydmlpanedvnilfees-tfkdriyegidpkrnrLYQTCSNAGVALTVM 226 Sporomusa sphaeroides
OUO35329  152 GLSTHnt-eVARLVVENp-eIEMMLFSVNPAfdmmpatdnlddlfgd---yagvgegginadraaLYARAEETGTGITVM 226 Olsenella sp. An290

Feature 1     ######               #                ####    #  ##  
NP_924840 244 KSFGGSgemlk-----kdllSPADALRYAMSl-pIATTVSGIesTAILEQNLR 290 Gloeobacter violaceus
KPK85718  203 KPFAGGsllqng---tavppTPVQCLSYALSqpaVATVVPGVkdPSELEAALA 252 Phycisphaerae bacterium SM23_33
PIV55018  217 KPFGGGvmtqpa--pdgtklSPLKLLKFVVQnplVNSVTPGVnyTYQIEELVK 267 Candidatus Desantisbacteria bacterium CG02_la...
AVM47301  227 KGLGAGllldakrspfgvamTVPQCIHYALTrpaVSSIVVGVqtPEEVAAAVR 279 Victivallales bacterium CCUG 44730
CDA79454  225 KPLAAGtllsaeaspfgvamTVPQCIQYALDrngVKCVIVGChsVEEVLQAVC 277 Ruminococcus sp. Marseille-P3213
EHL69374  225 KAFGGGdllseelspagralTLYQCISYALTrpaVAVVLAGAhtPDELRASVA 277 Synergistes sp. 3_1_syn1
CCZ81937  225 KVYGGGdllseanspfgkafTSVQCLEYALTrpgVASVMVGCrsCEEVQRAVD 277 Odoribacter laneus CAG:561
ALT68422  224 KGYASGrlfndndspfgvalTPIQCIHYALEqkgVASIFVGVnnVEELDAAIE 276 Methanobrevibacter millerae
OLS57000  227 KGYAAGvlfsdqaspfakalTPVQCLHYCLTrpaVASVMVGVanLQEILAATA 279 Sporomusa sphaeroides
OUO35329  227 KGYAGGrlldaaaspfgvalTPVQCIHYALTrpaVASIMVGFssPAHVAEAVA 279 Olsenella sp. An290

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