Conserved Protein Domain Family
AKR_unchar
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cd19097: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Links
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Statistics
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PSSM-Id: 381323
Aligned: 115 rows
Threshold Bit Score: 169.63
Created: 24-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###                                   #    #                        #      
NP_602504   1 MNLCLGTVQFGLNYGiekkr--idanKITEILITALKNKiVMLDTAQNYGnSEKLIGNFEKr----dSFKIISKIssssl 74  Fusobacterium nucl...
PKN34731   24 SRLVLGTAQLGMPYGianrkgkpdaaMAESIVRTAWECGiSRFDTAQAYGdSEAVLGRAFRslgivdEVRVITKLdprkp 103 Deltaproteobacteri...
OMF15888   17 SRYMLGTAQLGLGSYginnr--lgavDGSALLEYCEHTGiNCYDTAHEYGdAELKLGRFFIgk---qPPFIASKLkvdlh 91  Paenibacillus sp. ...
SEQ45881   12 SPFTLGTVQLGMDYGiankqgrpdqdASFSILRNALEAGvCSFDTAHAYGeSEQVLGSFFTdk---dKATIITKSnpeys 88  Virgibacillus subt...
OGV49646   12 SRMMLGTVQFGMSYGianrkgqpeyaDVKRLLAAAADAGiNCLDTAAAYGtSEEILGRALHelrltqKMFIVSKLrpltp 91  Lentisphaerae bact...
SHE11738   11 SKLTLGTVQLGIPYGinnregmlteeQGLRLLELAWSEGiTSFDTAAGYGrAEALLGRFSRg----kSPFIITKLktgvg 86  Chlamydophila abortus
PIQ85202    9 SQFVVGTAQLGMPYGiknksgrpdqaEAFEMIQCAIREDvIFFDTAQAYGdSEKILGNCFEalhaadKVRVITKLdpste 88  Candidatus Omnitro...
CCH48590    4 TNLILGTVQIGMNYGianatgkpdikTAREILQAAWDGGiQEFDTAIGYGeSEKILGVILHemgvssLAQINTKPhgswn 83  Desulfovibrio piez...
OGL70605    2 GELVLGTAQLGQKYGiantsgqpdqhTATEMVRVAFEGGiRFFDTAADYGeSERVLGQAFRdlrivdTVHVVTKVeas-- 79  Candidatus Uhrbact...
OGD21536    4 SRICLGTAQLGMDYGinnltgkpgleESRSIVRAAIERGiTTFDTAPVYGdSEQVLGRCLGew--pgEYVVVSKVpaldw 81  Candidatus Aminice...

Feature 1                                       ##                             ##             
NP_602504  75 n----nmndleELRNLLQTSLNNLniSSLDGLLLHKPedlk--nskLLDNLNILKEKGyFLNLGVSVYs--pDEANMALG 146 Fusobacterium nucl...
PKN34731  104 ------cedeqALRRSVEGSLKRLgvPVLHGLLLHREemldtmegvSSGSLKGLLQDGlVRRLGVSVYs--pERAWQALG 175 Deltaproteobacteri...
OMF15888   92 ht--selelerQMVQTTERIISRLkvDSLSALMIHDPvmlqvygdkVNSILHKLQKEGfIQRAGISFGa--dPVGQYAYS 167 Paenibacillus sp. ...
SEQ45881   89 iht-sevelekNMYCQVETSLTHLkiNKLPALLIHNPdillrhgttVTAVLKKMRSEGlVDKAGVSFGantdEQLQAIWD 167 Virgibacillus subt...
OGV49646   92 eehacpkaaeqAIRGSVEQSLSRLriDSIPMMLFHRMtd-----fpFMENLKKLKEEGlIQHLGVSCDkw-sDTALDIVA 165 Lentisphaerae bact...
SHE11738   87 gri-dpdkleqNMRKEAIDSLKLLgvSSIPLLMLHNTdvlkehgdaIEAGLRSLRKEGlIERAGISVAyn-tEEEYSLIG 164 Chlamydophila abortus
PIQ85202   89 ------assaqTILDTVHVSLRQLkiSSLFGCLLHRGkeldawsgkYEDIFMQLKRAGmIQHAGVSIYs--eSEFKKALQ 160 Candidatus Omnitro...
CCH48590   84 ------gqdfsEVKKDLEASLKKLhvEQLNTLLFHNEaileswtpkISDAVNALRDEGkIRNVGVSVYs--aDAAMRALS 155 Desulfovibrio piez...
OGL70605   80 --------dakRIEQRASESFARLgtANLYGVLLRWNdckdmprnvLSDIMDDLEHSDlVEHIGTSVYt--pEDAADALT 149 Candidatus Uhrbact...
OGD21536   82 ks--vpqavavEIRKRIETSLRNLgaPKLSICLFHRFedmylrgraALNALVSVRDEGlVEKIGCSVYt--pDEAESCLR 157 Candidatus Aminice...

Feature 1                 #                            #######                                
NP_602504 147 le-----niKYIQVPYNILDTrldkidFFKKAKSknkTIFVRSIFLQGVLLkqhnk-ypsfLEGLKEFDQFIESEIKKig 220 Fusobacterium nucl...
PKN34731  176 ln-----amDIIQIPASILDRrfqkagVFKAADDlgrQIYIRSAFLQGLVLvdadh-vpagMDAVKPVLERLETISRRyr 249 Deltaproteobacteri...
OMF15888  168 aglvqddifDMVQLPLNLFDRrmvqcgALEDFTSrgkWIIVRSVFLQGLFFlekdalpeaiQADGSILLETLHRLALEeg 247 Paenibacillus sp. ...
SEQ45881  168 fvkd--elyEVVQFPINILDHrmfhngGFQKLKEakkIVFARSIFLQGVLFfkade-lpahLVEAYEPLRILQDISFKsg 244 Virgibacillus subt...
OGV49646  166 ss-----svEAVQAGANILDQrylkmgLCRSAKShgvAVFIRSVYLQGLLMmeev---peaLQIVVPVRKRLAELAESag 237 Lentisphaerae bact...
SHE11738  165 srll-ndlyEAVQLPMNLLDHrplrngWLRKLKErgkLVFVRSVFLQGLILmqpne-lgktMAKAKSPLMELHDLAGKyr 242 Chlamydophila abortus
PIQ85202  161 ik-----eiDLIQLPFNLIDQraaregWFEAAEAagkKIFIRSIYLQGFLLmqpee-lptyMLFAQPILKAVVRLCRElq 234 Candidatus Omnitro...
CCH48590  156 np-----aiDVVQIPANLLDRrfekagILHKAQSlgkALQIRSIFLQGLLFmaphq-lpahMAFAKRDLADLHHILCEsn 229 Desulfovibrio piez...
OGL70605  150 tg-----afSLLQIPSNVLDRrfleagIPSVAREhgtQLFIRSIFLQGLLFmdpla-vpsaMFEAKPYLSAFHEFARTsg 223 Candidatus Uhrbact...
OGD21536  158 lp-----acEVIQVPFNLADKrllevgFFRKAKAsgkLVFARSVYLQGLFFkpel---pagLADFETFRAKLEALAVReg 229 Candidatus Aminice...

Feature 1        #                ######  #  ##         
NP_602504 221 ctKLTFLLNFIKNnkkIDYIIVGIDSLENLEEIIEAYNYKGL 262 Fusobacterium nucleatum
PKN34731  250 lsRQAMALLYLRDahsGASVIFGAEEPEQVRQNFRCWQEETP 291 Deltaproteobacteria bacterium HGW-Deltaproteobacteria-19
OMF15888  248 isVAELAMNYVRDlenVHCLVIGAETPEQIQHNLELLNRPAL 289 Paenibacillus sp. FSL H7-0331
SEQ45881  245 lsIAQLAVSFIRDldvVHSLVIGVENLEQLISTLSLMEGPEL 286 Virgibacillus subterraneus
OGV49646  238 igIAELALRYILSqegVSCVLIGVDNLSQLQENIKLFDLGPL 279 Lentisphaerae bacterium GWF2_52_8
SHE11738  243 fpLPQMAVSFVRDcgsADSLIIGAETEGQIRENLRLMAGPPL 284 Chlamydophila abortus
PIQ85202  235 mnPQELAFSFALNqskNSFMVVGAETQKQLADNIQLFKLTQK 276 Candidatus Omnitrophica bacterium CG11_big_fil_rev_8_21_...
CCH48590  230 ltLTAAAIGFVQAewpGCKILIGAETQKQVLDNLDAATIQIS 271 Desulfovibrio piezophilus
OGL70605  224 ysSHALTLQFIKWaypDAHLVVGAETPRQVQEHIDAWLLTVP 265 Candidatus Uhrbacteria bacterium RIFCSPHIGHO2_02_FULL_53_13
OGD21536  230 lgLAEMALRYVLSvdgIDSVITGVETAAQLGKNLDLVEKGML 271 Candidatus Aminicenantes bacterium RBG_16_63_16

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