Conserved Protein Domain Family
AKR_AKR11B3

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cd19085: AKR_AKR11B3 
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins
Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Statistics
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PSSM-Id: 381311
Aligned: 38 rows
Threshold Bit Score: 299.887
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Bacillus subtilis AKR11B (1PZ1) binds cofactor NADP.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###                               #    #                             #    
ABC69170   21 ITPIILGTWQAGKRNWa-dIDDQEIVAGIRAAVDAGITTIDTAEIYGdgdSERRVAEAIAp-----qRDQVTLLTKVFAN 94 
PIX40702   13 VTRVCLGCWQMGVGGWt-dVDDDNSIATIHRALELGVNFLDTAEGYGgghSEEVIGKALLg-----rREQVVVATKVSHS 86  Armatimonadetes ba...
OHD32698   13 LSSIIMGGSSPRGDFFksaDSRRNFEIVLSTALEGGVNTFDCAEAYGdgvAEKILGKVVRq-----iRDDVVLSSKVSYH 87  Spirochaetes bacte...
KMQ50220   12 PGICGLGCWAFGGKDWg-yQDPKVSLRTIKSAFDNGITLFDTAQSYGnglSEQLLGKALKh-----vRDRVFISTKAAYR 85  haloalkaliphilic b...
OWJ69093   24 QLPLAFGGSWFIPYSAp-gAQDAELTGAIEAAYEGGVRHFDTAGGYGnghSEEIYGAFLAg-----rRNEIFLASKANPA 97  Inquilinus limosus
PKL22478    7 KATLGLGCWAFGGGYWl-dQQRDDSIRTLHAALRGGIRHFDTAQGYGkglSEQLVGQQLKrfskevpREEYCLATKLFLP 85  Spirochaetae bacte...
OQY38028    8 LPKVGIGTWALGGEYWg-eQKHSDSIKTIHAARREKFTLFDTAPVYGkgkSEQLLGQQLSk-----eRENLTISSKCFLK 81  Spirochaetaceae ba...
ADK79429    8 PGGLGIGTWQFGDDPYwpgQQRKESLKAIDAALRAGIIHFDTAQVYGngrAEQLIGQRLRk-----rNDELFLATKLFPC 82  Spirochaeta smarag...
ORC37930   13 NPAPGLGSAAFGVIHQg-hQDDRDSLSALMTALDAGVRHIDTAAAYGsghSETVIGRLIRrrp--svRDGLVLASKGGIK 89  Candidatus Marispi...
EEH32344   11 YSKLILGSWQFGGGYFk-qVEKETAKTILKKAYDHGIRNIDTARAYGngiSEKIIGEIIEkdp--tiRENILIASKCYPM 87  Lyme disease spiro...
Feature 1                                                                    ##               
ABC69170   95 HlhhDQVITACENSLNRLqTDYIDLYQIHWPAgtwnsdlvPIAETMAALNQLKEQGKIRAIGVSNFsLAQLQEAMEhgqI 174
PIX40702   87 NctrDRFRVAFERSLSHLqTDYVDLYQIHWPWsk-----vSVEEPLEEMNKLKEEGKIRAIGVSNFgVPDLERAVKvaqI 161 Armatimonadetes ba...
OHD32698   88 NtsaKGIQRSCEASLRNLgTSYIDLYYLHYPNne-----vPLEESIGTLMKLKEEGKIRAIGLSNFsLNQMETALCfgeI 162 Spirochaetes bacte...
KMQ50220   86 Ps--GSIRKAVEKSLRRLkTDYIDLFYIHWPRtg-----aDLADCMEGLMRVKEEGKIGKIGVSNFsVNQMKEVMQaghI 158 haloalkaliphilic b...
OWJ69093   98 EataAAMSAEIDASLRRLkTDYVDLYYIHWPKsg-----vDMRPRMEALEAARRAGKIRAAGVSNFsVAQMRQVQEvgrI 172 Inquilinus limosus
PKL22478   86 Ks-pSDILASVQTSLRRLcTTYVDILYVHWPDst-----kDCRPYLQALGRVRAQGLVKHIGVSNFtQPLLQQALDateI 159 Spirochaetae bacte...
OQY38028   82 Pn--NQVEKSFENSLKRLnTDYIDIFFIHWPSsk-----lDSRPMIELLEKYRTQGKIKYIGLSNFnKTELDIARNagnI 154 Spirochaetaceae ba...
ADK79429   83 Pp--SSVEKRIALSRRRLfRESIDLLYIHWPKeg-----eDPRPMMEALESERRKGSIAGIGLSNFtVEQADKVLTvgkI 155 Spirochaeta smarag...
ORC37930   90 Gs-kKNFLKEIDNSRRRLgCEVVDIYYIHWPMeg-----vDPRPSLEALAEAREKRIIRYAGVSNFsPRQLRSAHAfipL 163 Candidatus Marispi...
EEH32344   88 Ei--SEYRENFNESLKNLkTDYIDIYYIHWPKad-----fDLRPIASFLEEMRVKGRIKYVGVSNFeISHMESIKKvckI 160 Lyme disease spiro...
Feature 1        #                            #######  # #             #                      
ABC69170  175 DSIQPPYSLFWRAIe-REIQPFCAAQqISILAYSSLAQGLLTGKFgp-dhQFAAGDHRSHnr----lyADPENYQRVQTA 248
PIX40702  162 DSLQPPFSLVWREIe-KEILPFCREHgISIMAYSPMAQGLIVGKYns--qEEIPADCRKGnv-----lTHDGVWEKVHAV 233 Armatimonadetes ba...
OHD32698  163 DVLQQCYSLLWRTYaeKYLFPFCVYHdVRVVAYGPLASGLLTGKFsk-dyRFERDDQRARagsdglllYLPEWWDRTTST 241 Spirochaetes bacte...
KMQ50220  159 DTHQLCYNLLWRREe-KEVIPFCSAHgIGVVTYSTLAQGILTGKFtr-dlSFETGDHRKStl-----fFEPDFWPVTCNC 231 haloalkaliphilic b...
OWJ69093  173 DAHQLGYNLLWRYAe-DELIPFCVAHgIAVVTYSTLAHGILTGKFgr-kpDLAPGDQRHRil-----pFRADIWPHVHAG 245 Inquilinus limosus
PKL22478  160 SYCQIPLSLLWTRSl-RNLAPLCTAHgLRIVAYSPLGLGLLGGRYrs-reDLDAKDLRRRlf-----pFDMQYVETFHNL 232 Spirochaetae bacte...
OQY38028  155 DIVQNGYNLLWTAD--QSYFEYCSNLgIKTQSYGTIAQGLLTGKFsntnpYKENTDLRYNnv-----lFNKKNISKVYKY 227 Spirochaetaceae ba...
ADK79429  156 DACQIGHSLLWRHAe-GGIIPWCREHnIPVIAYAPLAQGLLAGSFek--iHSNKDDRRNKll-----pMDPILSGALSRF 227 Spirochaeta smarag...
ORC37930  164 DACQFPYNLIWRNPe-TGLIPLCGELgIARVAYAALAQGFLTGKYpp-gsRFPHGDHRERta-----fFAEENARALGEG 236 Candidatus Marispi...
EEH32344  161 DVNQIGYNPLFRNKe-KDVIPYCEDNnIATISYSTIAQGLLSKANik--dKNKFNDIRTEkl----ilFKKEIWPYTLKT 233 Lyme disease spiro...
Feature 1                    #                ### #   #                           
ABC69170  249 LGLLKPIATTKNctLAQLAIAWLIRQp-qTNAIVGARNAQQAIANAQAidVELTAKDLEAIDHIGRTV 315
PIX40702  234 SKLVVETAAKYGksPAQVALNWCLATpgvTNVIAGARRPAHIADSTGAdgWQMEQADYDRLSAAGLEA 301 Armatimonadetes bacterium CG_4...
OHD32698  242 VEKLKPFVNTYGvtLTQLAINWVLNRpdvDGVIIGARTTGQVVENIASesLQISEKDKQEMDKISKVF 309 Spirochaetes bacterium GWC2_52_13
KMQ50220  232 VDQLRSLSDDSKrpLLQIAIQWVMQKkfiSSALVGARNENQVYDLVQTvsDNIDPEVLKKAEKVSDSF 299 haloalkaliphilic bacterium ACh...
OWJ69093  246 VERLKAIAAELDrpLMHLAIRWNLSRpgiTFVVAGARNRAQSEANAAAlsGAIPPSVLERMTAISDEI 313 Inquilinus limosus
PKL22478  233 LHALEQTALEYAtdMATVALAWVLAQp-vDTVLTGARTKDQLYANLHGqtIPLAGSHLVALRQIADNL 299 Spirochaetae bacterium HGW-Spi...
OQY38028  228 IDLLKKIGMDEGlsIYELTLAWTIKRpflDSILVGCRNRKQIEALKNAitKDISAKSVNLITELSKQF 295 Spirochaetaceae bacterium 4572_7
ADK79429  228 LESFEHEADNIGvpPAGLALAWSLSRpflQAVVVGARNRKQVEEAAAArsFMLPPQTEANLETISLRF 295 Spirochaeta smaragdinae
ORC37930  237 LKKLKGLCDAYNtaLPVAALQWIVSRehiESGLVGARTASQAKENFIL--PAADPALLREIDNEGKEI 302 Candidatus Marispirochaeta sp....
EEH32344  234 INKLEEIAKINNltILELTYSWLKKTk-lSGFIVGFSKENYVESNVNSfkAEINDKVYEEITSILDNF 300 Lyme disease spirochete

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