Conserved Protein Domain Family
bHLH_TS_OLIG1
?
cd18942: bHLH_TS_OLIG1 
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) and similar proteins
Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), is a bHLH transcription factor that promotes formation and maturation of oligodendrocytes, especially within the brain.
Links
?
Statistics
?
PSSM-Id: 381512
Aligned: 5 rows
Threshold Bit Score: 132.045
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   # ### #    #                                      ####                
Q8TAK6       101 EQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAahc--------------qgAPGRKLSKIATLLLARNYILLLGS 166 human
XP_003228407  39 SEQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAahc--------------qsSPGRKLSKIATLLLARNYILLLGS 104 green anole
XP_004912200  68 EEQQQLRKKINSRERKRMQDLNLAMDALREVILPYSAthc--------------qsSPGRKLSKIATLLLARNYILLLGS 133 western clawed ...
NP_001018632  56 EEQQELRRKINSRERKRMQDLNVAMDALREVMVPYSSsptgvggalqhpyfppgapTTGRRLSKISTLVLARNYILLLGS 135 zebrafish
OCT91249      56 EEQHQLRKKINSRERKRMQDLNLAMDALREVILPYSAthc--------------qsSPGRKLSKIATLLLARNYILLLGS 121 African clawed ...

Feature 1                 
Q8TAK6       167 SLQELRRAL 175 human
XP_003228407 105 SLQELRRIL 113 green anole
XP_004912200 134 SLQELRRLI 142 western clawed frog
NP_001018632 136 SLQEMRRLL 144 zebrafish
OCT91249     122 SLQELRRLI 130 African clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap