Conserved Protein Domain Family
bHLH-O_ESM5_like
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cd18916: bHLH-O_ESM5_like 
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster Enhancer of split proteins, E(spl)m5, E(spl)m8 and similar proteins
The family includes two bHLH-O transcriptional repressors, E(spl)m5 and E(spl)m8, which participate in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. They bind DNA on N-box motifs, 5'-CACNAG-3'.
Links
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Statistics
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PSSM-Id: 381486
Aligned: 5 rows
Threshold Bit Score: 98.7559
Created: 16-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NPAS3 (5SY7)-ARNT complex binds HRE DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###  # ##   #                              ##                   
P13098        12 KVKKPMLERQRRARMNKCLDNLKTLVAELrg--------dDGILRMDKAEMLESAVIFMRQQKTPKK 70  fruit fly
AEV91210       9 RTKKPMLERHRRARVTNCLSTLRQLIAECsd--------nDNVLRMDKIVMLETTIAYMRQQQSAKK 67  Teleopsis dalmanni
P13096        20 KVKKPLLERQRRARMNKCLDTLKTLVAEFqg--------dDAILRMDKAEMLEAALVFMRKQVVKQQ 78  fruit fly
XP_020906554  15 KSMKHLLERQRRARINHSLSELKSLVLSAihqgn-pqadlNGCEKMEKAEILELTVNYIKSINTRGN 80  Exaiptasia pallida
XP_020906375  14 KSTKPMIERQRRARINQRLEEIKDLILSSlyhddpqmyneKSCVRMDKAEILEFAVEFIKNQRTARN 80  Exaiptasia pallida

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