Conserved Protein Domain Family
TET1
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cd18895: TET1 
oxygenase domain of ten-eleven translocation (TET)1 methylcytosine dioxygenase and similar proteins
TET1 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Human TET1 (and TET2) are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET1 plays multiple roles in in tumor development and progression. TET1 serves as a tumor suppressor gene; loss of TET1 is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy. In addition to its dioxygenase activity, it can induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription. The regulation of TET1 is also correlated with microRNA in a posttranscriptional modification process. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.
Links
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Statistics
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PSSM-Id: 380674
Aligned: 5 rows
Threshold Bit Score: 660.838
Created: 2-Apr-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Comment:based on related TET2 proteins with structure
  • Comment:TET converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
AHE93329     1190 CDCVEHIIEKEEGPYYTHLGSGPNVAAVREMMETRYGEKGNAVRVEVVVYTGKEGRSSQGCPIAKWIIRRGSEQEKLLCL 1269 zebrafish
EOB09011     1439 CDCVEQIIEKDEGPYYTHLGTGPSVAAVREIMENRYGAKGSAVRIEVVVYTGKEGKSSQGCPIAKWVIRRSSDEEKLLCL 1518 mallard
Q8NFU7       1422 CSCLDRVIQKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCL 1501 human
XP_005990016 1436 CDCVEQIIEKDEGPYYTHLGAGPSVAAVREIMESRYGEKGKAIRIEVVIYTGKEGKSSQGCPIAKWVIRRSNDEEKLLCL 1515 coelacanth
XP_007897316  895 CDCVEQIIEKDEGPYYTHLGAGPNVAAVREMIEDRYGEKGKAIRIEVVIYTGKEGKSSQGCPIAKWVIRRSNEEEKLLCL 974  elephant shark

Feature 1                                                        # ##                       #     
AHE93329     1270 VRQRAGHCCQNAVIVILILAWEGIPRSVADRLYQELTQTLCKY-GSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSW 1348 zebrafish
EOB09011     1519 VRQRAGHHCQTAVIVILILAWEGIPHLLADTLYKELTQSLRKY-GCPTSRRCALNEDRTCACQGLDPETCGASFSFGCSW 1597 mallard
Q8NFU7       1502 VRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYnGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSW 1581 human
XP_005990016 1516 VRQRAGHHCQNAVIVILILAWEGIPRLLADKLYQELTDTLKKY-GSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSW 1594 coelacanth
XP_007897316  975 VRQRAGHRCQTAVIVILILAWEGIPRTLADKLYQELTQTLRKY-GSPTNRRCALNEDRTCACQGLDPERSGASFSFGCSW 1053 elephant shark

Feature 1                                                                                         
AHE93329     1349 SMYFNGCKFARSKtPRKFRLqgdspkEEGRLEKNLQNLASDLAPVYKRlAPKAFHNQVEQEQRGQDCRLGcrEGRPFSGV 1428 zebrafish
EOB09011     1598 SMYFNGCKFARSKnPRKFRLltddpkQEELLENNLQTLATDVAPVYKKlAPEAFQNQVENEHMGPDCRLGskDGRPFSGV 1677 mallard
Q8NFU7       1582 SMYFNGCKFGRSPsPRRFRIdpssplHEKNLEDNLQSLATRLAPIYKQyAPVAYQNQVEYENVARECRLGskEGRPFSGV 1661 human
XP_005990016 1595 SMYFNGCKFARSKyPRKFKLltddskEEEKLDSNLQNLATDVAPVYEKlAPDAFHNQVEQEHVAPDCRLGlkEGRPFSGV 1674 coelacanth
XP_007897316 1054 SMYYNGCKFARSKyPRKFKLltddikEEEMLESYLQELASDVAPVYQKlAPEAYGNQIMNENIASNCRLGlkSGRPFSGV 1133 elephant shark

Feature 1         #           # ##                                                                
AHE93329     1429 TACVDFCAHAHKDTHNMTNGSTVVCTLTKEDNRAVrnIPEDEQLHVLPLYKISDTDEFGkvEGQWAKIKTGALQVLSAFP 1508 zebrafish
EOB09011     1678 TACIDFCAHAHKDTHNMHNGSTVVCTLTKEDNRRVgvIPSDEQLHVLPLYKISQTDEFGteEGLEAKIKAGAIQVLTAFP 1757 mallard
Q8NFU7       1662 TACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLgvIPQDEQLHVLPLYKLSDTDEFGskEGMEAKIKSGAIEVLAPRR 1741 human
XP_005990016 1675 TACIDFCAHAHKDTHNMHNGSTVVCTLTKEDNRSVgaIPEDEQLHVLPLYKISQTDEFGdeAGQEAKIKNGAIQVLSAFP 1754 coelacanth
XP_007897316 1134 TACIDFCAHSHKDQHNMRNGSTVVCTLTKEDNRTVnsIPEDEQLHVLPLYKISHADEYGneDIQEEKMKNGAIQVLSSFP 1213 elephant shark

Feature 1                                                                                         
AHE93329     1509 REVRllaepvksahkrrleakrahveklnslgskqvtpvkmknespkgfkqtstenssfseknspnlsstmrvpdiggqy 1588 zebrafish
EOB09011     1758 REVRmlaeplratkkkkpdtrrtptekqplidkkystpvklkteapenlsntlhclgnktdalkpgikmetsdhlyamkh 1837 mallard
Q8NFU7       1742 KKRTcftqpvprsgkkraammtevlahkiravekkpiprikrknnstttnnskpsslptlgsntetvqpevksetephfi 1821 human
XP_005990016 1755 REVRllaepvksskkkkqdskrvaadkqnnpdkkqstptkskdgllnaqsnspqqlgnrtsslqkltamkmesqehqnaf 1834 coelacanth
XP_007897316 1214 REVRilaepvksarkkkleakraaldkqekkhstsgklkegaadkhcsaihqcsagckmetasssmktrpqdhynsfkyt 1293 elephant shark

Feature 1                                                                                         
AHE93329     1589 splhsggsynqsnscrtppv------------------------------------------------------------ 1608 zebrafish
EOB09011     1838 tsnttkncsllkqytasppfkvdslhpysslahkpgltavtniqqdfsvp------------------------------ 1887 mallard
Q8NFU7       1822 lkssdntktyslmpsaphpvkeaspgfswspktasatpaplkndata--------------------------------- 1868 human
XP_005990016 1835 kyagptsvgsysllgnytpsssynlcsvypfpsipqpgtptvsnfqqnfsvpygyigyngnqhyvssymkysnfnmsvng 1914 coelacanth
XP_007897316 1294 ghtgvgnysplggftspapynlggvypystliprpnlptlpsfqhsfsvpygylgypgnqhflsp-ftkynnvemmingf 1372 elephant shark

Feature 1                                                                                         
AHE93329     1609 -------------------------------gssfgtstlpkfphdpsggtthfngsppfrhgtikqepfrndpvrtnpk 1657 zebrafish
EOB09011     1888 --ygyfecsskqphvtpyincknfdvsvkdytgillndkmngvppilpevtapgppahtdplpsilehqpdkqncqpqld 1965 mallard
Q8NFU7       1869 ----scgfsersstphctmpsgrlsganaaaadgpgisqlgevaplptlsapvmeplinsepstgvtepltphqpnhqps 1944 human
XP_005990016 1915 ytgtlfedtksnvqhsfsnsssadqnhidslnrmfenqvvkeqkipnqlpnsqfsqlsnacnslekifanskatnvntnk 1994 coelacanth
XP_007897316 1373 sgsalddkkadipqllpnmnfsvqqgrtdsldqiyknatqftqqrkpqaikeqtshsqlpgscdnmslsletkttdtskp 1452 elephant shark

Feature 1                                                                                         
AHE93329     1658 fksepeemrcfqggaaptplsppmaeglhsrlnitaqpvtpevakaeEVWSDSEHNFLDkNIGGVAVAPSHGSILIECAR 1737 zebrafish
EOB09011     1966 nspssqmissgdlsvpqsspardavgneadcshgalgqptdseekaeELWSDSEHNFLDdDIGGVAVAPSHGSILIECAR 2045 mallard
Q8NFU7       1945 fltspqdlasspmeedeqhseadeppsdeplsddplspaeeklphidEYWSDSEHIFLDaNIGGVAIAPAHGSVLIECAR 2024 human
XP_005990016 1995 pngfhklhlqkrcleshqgyvqgsdsnsykmqsseipapmgngtlpeEVWSDSEHNFLDeDIGGVAVAPSHGSILIECAR 2074 coelacanth
XP_007897316 1453 nglvklqlggnfrefqqsftqdeslippkaenneeptpmgtsekpvqEVWSDSEHNFLDeDIGGVAVAPSHGSVLIECAR 1532 elephant shark

Feature 1                               # # #                           
AHE93329     1738 RELHATTPILRPDRtHPTRISLVFYQHKSLNAPgHGLQQWEAKRAEKAREKEQA 1791 zebrafish
EOB09011     2046 RELHATTPIKKPNRnHPTRISLVFYQHKNLNEPkHGLAMWEAKMAERAKEKEKE 2099 mallard
Q8NFU7       2025 RELHATTPVEHPNRnHPTRLSLVFYQHKNLNKPqHGFELNKIKFEAKEAKNKKM 2078 human
XP_005990016 2075 RELHATTPIKKPNRnHPTRISLVFYQHKSLNEPkHGLALWEAKMAERAKEREEE 2128 coelacanth
XP_007897316 1533 HELHATTPVKKPNRhHPTRISLVFYQHKNLHEPkHGLALWEAKLTKMAERAKEK 1586 elephant shark

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