3G60,4F4C


Conserved Protein Domain Family
ABC_6TM_Pgp_ABCB1_D2_like

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cd18578: ABC_6TM_Pgp_ABCB1_D2_like 
Click on image for an interactive view with Cn3D
Six-transmembrane helical domain 2 (TMD2) of P-glycoprotein 1 (Pgp) and related proteins
P-glycoprotein 1 (permeability glycoprotein, Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. Pgp acts as an ATP-dependent efflux pump, binds drugs with diverse chemical structures and pump them out of the drug resistant cancer cells. It is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. Pgp consists of two alpha-helical transmembrane domains (TMDs) and two cytoplasmic nucleotide-binding domains (NBDs). This protein also functions as a transporter in the blood-brain barrier. In addition to Pgp, breast cancer resistance protein (BCRP/MXR/ABC-P/ABCG2) and multidrug resistance-associated proteins (MRP1/ABCC1 and MRP2/ABCC2) function as drug efflux pumps of anticancer drugs, and overexpression of these transporters induces multidrug resistance to a broad spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively pumping the drugs out of cells.
Statistics
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PSSM-Id: 350022
Aligned: 614 rows
Threshold Bit Score: 187.274
Created: 11-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this ABC transporter family contain 6 alpha-helices in each transmembrane domain (TMD) for a total of 12 TM segments in the complete transporter.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ########################                                             
3G60_A     697 LKLNSTEWPY-FVVGIFCAIINGGLQPAFSVIFSKVVGVFTnggpp--etqrQNSNLFSLLFLILGIiSFITFFLQGFTF 773  house mouse
OLL24745   749 AIIGLPSKFA-LCVGILASVINGTATPLFSFALSRLLSSLFsqti---lddtSFANHWTLIVLLIAFaDGLSFAFKTYFL 824  Neolecta irregul...
KTW31622   726 NWRFINKKTY-FILGLLFCIGNGFSTPLFSYALSKLLALFFssktm--lqikKKSSEYSMFILGVSFfDSLTLYLKIYLL 802  Pneumocystis car...
ESA00584   638 IRETMDNKSF-YYIGIIATVINGLVMPAFSFVLANLLNTYSiadk---dklmYESRKFALYVLLIAIiNGISTHFKYYLL 713  Rhizophagus irre...
ODV92316   723 IAPGRANYFL-LVPGIIAAIACGIFPAVFSYCLSHLISSLTep--------aDKSLFWALILICVAAgEGVSLFSRVLVL 793  Tortispora casei...
CDO55963   900 CYKRVRSKGL-LWLGVILSIINGGLTPLFSSVVARLITYMVtpvnpsgvsqsSYPTLWIALALTLALvDGLTTYGRTVVL 978  Galactomyces can...
OAO17182   705 LRYAGKRRTY-FWIGMIGTFFRMLFPPVFAFCTAILQHLMYvtdl---aqfqLYGALLITPVLVTAVlSLVGTALNWECH 780  Blastocystis sp....
OAO12021   723 LSLVGPNRYL-FWVGLIGTVLRFFFPPVFGYCIAMILSMFYyfdl---aqfkADSWKVILPVILTAFcTFFGTVINWGLH 798  Blastocystis sp....
KXS21056  1013 FLMNRPEWLL-IAVGSTFAAIRGAVLPCFAVALAMAFSVISgst-----dpfGNVGIWVMILAVLACaEGLFFYLKVVVL 1086 Gonapodya prolif...
CBK24613   595 LLQLIPQYKWlFWTSFIGNIVRAIYPTIYAYCTAILQELLFtsdl---nllwDKGMICVYILLGFGViNFLATIYYWDAG 671  Blastocystis hom...
Feature 1                                                                                      
3G60_A     774 GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAvIFQNIANLGTGIIISLIY--GW 851  house mouse
OLL24745   825 DRCGQIWVNVIRRTSMEKILMQDQRWFDITDHSASAITRILMSDTESLRSILGRYAGsLLVAVTMIVMGIIWSLIV--GW 902  Neolecta irregul...
KTW31622   803 EYCADSWITNIRSTLFRNMLSQDIHYFSEKTYSSENTTRIIINETELTRSIFEQITGnILVAVVMVLVGVIWSFVI--AW 880  Pneumocystis car...
ESA00584   714 ERASERWAVRLRHLGFGKVLRQPQSWFDKPENATGKVTTILTTDTESSKNLIGQFAGnIILGLISLFGGIIWAFAV--GW 791  Rhizophagus irre...
ODV92316   794 EKVADRLVSAVKFDAFTRTIHQRPGWLSESSLDVSAVWQTLIGDTENIRDSLDKVGGvFISVVFTFSASLIWALIA--GW 871  Tortispora casei...
CDO55963   979 GYVADQWVCDMRDRALRMVLLQDVTWHTQNRIETNDLTALIISHSEEIRTILTVLLAvTVTTISLSFICVIWVLVV--SW 1056 Galactomyces can...
OAO17182   781 SIVGEDLIANLRSLCYRKLIYAPIAFFDDPQHMSAVLSSRLSIDCRRIRDLIDRIYP-IIENVFFAVAGLVLCFSPtgNW 859  Blastocystis sp....
OAO12021   799 STVGEDLIVSIRSKAFSKLIHSPVPFFDEPRHLPAVLTSRLGIDCRRLRDIIDYVSP-IIENSLLVIGCLLLCFGPtgNW 877  Blastocystis sp....
KXS21056  1087 EVTGERLTMRVRRQLFDAVLGKSLQWFAQPGHGTDVILARMATDAPRIRGATTSNLGnVINFAVGFLVGAVWALAV--GW 1164 Gonapodya prolif...
CBK24613   672 GIVGEHLIASVREHSYKKYITMPLAFFDDPNHLPSILTSRLSIDGRRVRDLVDRMGP-IFENYLLVIISLVVCFTPvgNW 750  Blastocystis hom...
Feature 1                                                                                      
3G60_A     852 QLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGsgKIATEAIENFRTVVSLTREQKFETMYAQSLQipYRNAMKKA 931  house mouse
OLL24745   903 QLTLAGLSVAPVMYLSTRLYAWLVDQSQKKCYEALEKvwDLQYDCIFNHEILKVFVLNPLMRKRHNEAVDnlDKCSSQRA 982  Neolecta irregul...
KTW31622   881 KLSIIVVGIAPLLYISVRCNSYLNTKWDNKYKDENINamSILYEYSENIFTVKALLLDNFFQKKFMLSIEriFAKGIQRA 960  Pneumocystis car...
ESA00584   792 QLTLVGFGLVPLLLIISELQGFILQKYEKSQKLATENaaNSFYQTISSLRTVFSLAIEPAMENKFHSSLEkpYKIGVKKA 871  Rhizophagus irre...
ODV92316   872 KLTLVSIAPIFGVMFVFWCYIRLSKHFESKSLELKNDsnSLMSQFIICIRSVKVYSVEPLFEALHNDVVQkqKNLGLQRE 951  Tortispora casei...
CDO55963  1057 RLCFIGMGLASLYYFAAIFSKYVVIRWEGKCIHLNALleEHIHETVSGIRTLRILGLERLFVRRFDAAASnlRVAKIRDS 1136 Galactomyces can...
OAO17182   860 KLSIIAIALSPFLVAVEYLQWRVISRITEKVDNALALrsGELTDYLLNIHTLHAYNLEDTLLQGLRQRIEeaNRLTDKRT 939  Blastocystis sp....
OAO12021   878 KLAIPAIILSPFLIAVEYLQALITSIITEKIDNDLTKksGILTDYLLNIHTIHAYNLEDTLFDEMMDSMRntDKLTNKRT 957  Blastocystis sp....
KXS21056  1165 KLALVGLAFVPVVLVAAQMEAASVTSTEGRTSKALGDgdRISFEAVGNIETIKAMALEGWFVDRYRRNWDsgKAYESWLG 1244 Gonapodya prolif...
CBK24613   751 KLTLVAVCMSPFLLTVEYMQWMIMAKVSDQIDKELTErsGELTDCVLNIHTVHAYNLQNTLSHQLMKKLEptNKKTTERY 830  Blastocystis hom...
Feature 1                                                                                      
3G60_A     932 HVFGITFSFTQAMMYFSYAACFRFGAYLVTQqlMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKT 1011 house mouse
OLL24745   983 LASGFGHGMTEAISYLTKALLFWYGGYLVANgtYTAVRLLTVFTILMFSLSNASQSISLLPQISRTKEAAKHIYTLSNLE 1062 Neolecta irregul...
KTW31622   961 IYIGFGHGITESIIFSFQALLFWYGSKFILNrtYTPIVVLTIFSLIIFSVVTASQFLSMVPQYNKVKKAYQSVKNLFNIS 1040 Pneumocystis car...
ESA00584   872 FICGFTSGFLDSLSYLTKVVTFGYGAKLVSDgvYDLQTMLVVWTLVIFCTTSASQMLATIPYYAKSKQAIKTIDKIINLP 951  Rhizophagus irre...
ODV92316   952 LYSGLLFGLLDSSIQFCKVLCLWYGFRLVITeeYSFTSTMTVLAMIIFALVNVLDFVNDIPMVTKSSQAFRKIAPLLKLS 1031 Tortispora casei...
CDO55963  1137 FYSGIGFGLNGLISYGAQGLLLWYGMKLIADetYPSSKVLMVYSILFFSISSISTLLAALPQMHTTFAVCFRLFQILDFD 1216 Galactomyces can...
OAO17182   940 LRASVGQGLSLFFPSVYLIVLLSIGSGMITRgsMTFTQMFMVMMAVYMCAQYIGINMAYTPAMKLAQQSANNVFALLAEK 1019 Blastocystis sp....
OAO12021   958 WRSALGQGLSQLLPSLFMIIVLAVGSVLMVSkeASFEQVFTVMMAVYMCAQFVGINMAYMPNMKLAQKSTNNVFALLNEM 1037 Blastocystis sp....
KXS21056  1245 FALAFGFALSQMAVFMCQAVLFYYGGRLITLdeYAIYQVLIVWALLVFCCVTAGQVIGLSSVVSKARESATVISELITSY 1324 Gonapodya prolif...
CBK24613   831 IRGAIGQGLSLLMPCAYDVVVLLVAFSMLQKgeIDFAHMMFVYMAINTCAATVGFNMAYTASNDLAKRSAYNLLSVINME 910  Blastocystis hom...
Feature 1         
3G60_A    1012 PEI 1014 house mouse
OLL24745  1063 VDT 1065 Neolecta irregularis DAH-3
KTW31622  1041 EKN 1043 Pneumocystis carinii B80
ESA00584   952 VTS 954  Rhizophagus irregularis DAOM 181602
ODV92316  1032 LDE 1034 Tortispora caseinolytica NRRL Y-17796
CDO55963  1217 PNL 1219 Galactomyces candidum
OAO17182  1020 NAN 1022 Blastocystis sp. ATCC 50177
OAO12021  1038 NPD 1040 Blastocystis sp. ATCC 50177
KXS21056  1325 DDR 1327 Gonapodya prolifera JEL478
CBK24613   911 NEN 913  Blastocystis hominis

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