Conserved Protein Domain Family
BACK_KBTBD2
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cd18479: BACK_KBTBD2 
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.
Links
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Statistics
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PSSM-Id: 350554
Aligned: 6 rows
Threshold Bit Score: 178.326
Created: 5-Oct-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8IY47       128 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFtaVYHQDAFMQLShDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 207 human
XP_007899059 127 INAENCVRLLSFADLYSCEELKASAKRMVEHKFtaVYHQEAFLQLShDLLIDILSSDNLNVEKEETVREAAMVWLEYDTE 206 elephant shark
NP_001070628 129 ITAENCVRMLSIGDMFSCTELKQSAKRMVEHKFpvVYRQEAFLQLShELLLDLLSSDNLNVEKEETVREAAMLWLEYNME 208 zebrafish
EOB05401     128 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFtaVYHQEAFMQLShDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 207 mallard
XP_006000205 128 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFtaVYRQEAFMQLShDLLIDILSSDNLNVEKEEAVREAAMLWLEYNTE 207 coelacanth
XP_018123078 128 INAKNCVRLLSFADLFSCEELKQSAKRMVEHKFttVYHQEAFMQLSsELLIELVSSDNLNVEKEETVREAAMSWLDYNTV 207 African clawed ...

Q8IY47       208 SRSQYLSSVLSQIRID 223 human
XP_007899059 207 SRSQYLSSVLGQIRID 222 elephant shark
NP_001070628 209 GRSQYLSSVLSQIRID 224 zebrafish
EOB05401     208 SRSQYLSSVLSQIRID 223 mallard
XP_006000205 208 SRSQYLSSVLSQIRID 223 coelacanth
XP_018123078 208 SRSQYLSTVLSHLRID 223 African clawed frog
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