4BMD,2L42


Conserved Protein Domain Family
BRCT_Rad4_rpt3
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cd18433: BRCT_Rad4_rpt3 
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third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins
Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.
Links
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Statistics
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PSSM-Id: 349386
Aligned: 22 rows
Threshold Bit Score: 70.0342
Created: 18-Jul-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:The Trp-X-X-X-Cys/Ser is considered a signature motif of the BRCT family.
  • Comment:Trp in BRCT sequence motif is not conserved in some family members.
  • Citation:PMID 9799248
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
4BMD_A         12 LFKNLTFYLYEFPNtk-----vSRLHKCLSDNGGQISEFLss------------tiDFVVIPHYFPvdel---------- 64   fission yeast
730470        302 LFKNLTFYLYEFPNtk-----vSRLHKCLSDNGGQISEFLss------------tiDFVVIPHYFPvdel---------- 354  fission yeast
1352999       326 IFKNCAFIIHHIFPgn----hrSILTKIVVQNGGKIETSYlsgi---------ydhSYYIIPSNKAldsfndl------- 385  baker's yeast
XP_001905411  536 VFASCCFFIHGFSAkk-----tEMLLNTVASLGGMICHSLeevssas---gaqmahRFFIIPQESPpeiqp--------- 598  Podospora ans...
KZZ99612      323 VFVRCVFAIHGFDDkr-----hMVLEDIITTLCGSVSSSVreaaasp--sfaeyshRFLVVPQTSQpsthp--------- 386  Aschersonia a...
ERS98577      349 VLSTSIFCIHGFSPer-----tNVLAGAVATMGGAIASSLaemaaiasrrpdtplfQHVIVPQEERpethp--------- 414  Sporothrix sc...
XP_016640664  324 IFSTSFFFIHGFDQrk-----fDILNQTITALGGRVCRTLdevclar--apehpwhRFLVIPQDSPsippelsptslpsn 396  Scedosporium ...
OON06083      305 SFSFSTFAIHGFEDtq-----iRAMTTLISKYGGCIRSKEt--------------aAYIIVPFTNRskksln-------- 357  Batrachochytr...
ORX87579      445 LFEGLNFVSKGFSPnh-----eQIIEKEVLKHSGQYFHSEisi----------knnYYQILPFINTlnii---------- 499  Anaeromyces r...
2L42_A         11 PLSNMKFYLNRDADahdslndiDQLARLIRANGGEVLDSKpre----------skeNVFIVSPYNHt------------- 67   baker's yeast

Feature 1                         #   #      
4BMD_A         65 -----pifSFPTVNEWWIERCLYYKKI 86   fission yeast
730470        355 -----pifSFPTVNEWWIERCLYYKKI 376  fission yeast
1352999       386 --peiiddNDGIVTEFFIERCLYYQKL 410  baker's yeast
XP_001905411  599 ----kvpeNVSIITEFYIEKCLHNKRF 621  Podospora anserina S mat+
KZZ99612      387 ---svsyeNVDVVTEFYIEQCLHSKQF 410  Aschersonia aleyrodis RCEF 2490
ERS98577      415 ----avanDVLLVTEFFIERCLHKKQY 437  Sporothrix schenckii ATCC 58251
XP_016640664  397 lhsdetttTPQIVTEFFLERCIHSKTL 423  Scedosporium apiospermum
OON06083      358 ---fkgtsTGCLVTEYWFEASIEQNIL 381  Batrachochytrium salamandrivorans
ORX87579      500 -----vsqKAIIVTEHWLERCLIDDIL 521  Anaeromyces robustus
2L42_A         68 --------NLPTVTPTYIKACCQSNSL 86   baker's yeast

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