Conserved Protein Domain Family
BTB_POZ_KCTD11

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cd18370: BTB_POZ_KCTD11 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11
KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.
Statistics
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PSSM-Id: 349679
Aligned: 3 rows
Threshold Bit Score: 172.492
Created: 5-Dec-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014717001 104 VTLNVGGTLYSTtLETLTRFPDSMLGAMFRagtpippnlntqgGGHYFIDRDGKAFRHILNFLRLGrldlprgygeTALL 183 ass
XP_006037391 208 VTLNVGGKLYTTtVETLTRCPDSMLAAMFRggprp---shmdrQGHYIIDRDGPTFRHVLNFLRTGqlqlpegyseLGLL 284 Chinese alligator
XP_008686177  41 VTLNVGGTLYSTtLETLTRFPDSMLGAMFRagtpippnlnpqgGGHYFIDRDGKAFRHILNFLRLGrldlprgygeTALL 120 polar bear
XP_014717001 184 RAEADFYQ 191 ass
XP_006037391 285 ATEADFYQ 292 Chinese alligator
XP_008686177 121 RAEADFYQ 128 polar bear
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